Bone marrow derived mesenchymal cell mobilization by granulocyte-colony stimulating factor after acute myocardial infarction: results from the Stem Cells in Myocardial Infarction (STEMMI) trial

Rasmus Sejersten Ripa, Mandana Haack-Sørensen, Yongzhong Wang, Erik Jørgensen, Steen Mortensen, Lene Bindslev, Tina Friis, Jens Kastrup

116 Citations (Scopus)

Abstract

Granulocyte-colony stimulating factor (G-CSF) after myocardial infarction does not affect systolic function when compared with placebo. In contrast, intracoronary infusion of bone marrow cells appears to improve ejection fraction. We aimed to evaluate the G-CSF mobilization of subsets of stem cells.
Original languageEnglish
JournalCirculation
Volume116
Issue number11 Suppl
Pages (from-to)I24-30
ISSN0009-7322
DOIs
Publication statusPublished - 11 Sept 2007
Externally publishedYes

Keywords

  • Aged
  • Antigens, CD34
  • Bone Marrow Cells
  • Double-Blind Method
  • Female
  • Granulocyte Colony-Stimulating Factor
  • Hematopoietic Stem Cell Mobilization
  • Humans
  • Male
  • Mesenchymal Stem Cell Transplantation
  • Mesenchymal Stromal Cells
  • Middle Aged
  • Myocardial Infarction
  • Ventricular Function, Left

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