Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians

Jonas B Møller; Maria Pedersen; Haruhiko Tanaka; Mitsuru Ohsugi; Rune V Overgaard; Jan Lynge; Katrine Almind; Nina-Maria Vasconcelos; Pernille Poulsen; Charlotte Keller; Kohjiro Ueki; Steen H Ingwersen; Bente K Pedersen; Takashi Kadowaki

doi:10.2337/dc13-0598

Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians

Jonas B Møller, Maria Pedersen, Haruhiko Tanaka, Mitsuru Ohsugi, Rune V Overgaard, Jan Lynge, Katrine Almind, Nina-Maria Vasconcelos, Pernille Poulsen, Charlotte Keller, Kohjiro Ueki, Steen H Ingwersen, Bente K Pedersen, Takashi Kadowaki

Department of Clinical Medicine

83 Citations (Scopus)

Abstract

OBJECTIVE This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and b-cell response. RESEARCH DESIGN AND METHODS A total of 120 Japanese and 150 Caucasians were enrolled to obtain comparable distributions of high/low BMI values across glucose tolerance states (normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes), which were assessed by oral glucose tolerance tests. BMI in the two cohorts was distributed around the two regional cutoff values for obesity. RESULTS Insulin sensitivity was higher in Japanese compared with Caucasians, as indicated by the homeostatic model assessment of insulin resistance and Matsuda indices, whereas b-cell response was higher in Caucasians, as measured by homeostatic model assessment of b-cell function, the insulinogenic indices, and insulin secretion ratios. Disposition indices were similar for Japanese and Caucasians at all glucose tolerance states, indicating similar b-cell response relative to the degree of insulin resistance. The main determinants for differences in metabolic indices were measures of body composition, such as BMI and distribution of adipose tissue. Differences in b-cell response between Japanese and Caucasians were not statistically significant following adjustment by differences in BMI. CONCLUSIONS Our study showed similar disposition indices in Japanese and Caucasians and that themajor part of the differences in insulin sensitivity and b-cell response between Japanese and Caucasians can be explained by differences in body composition.

Original language	English
Journal	Diabetes Care
Volume	37
Issue number	3
Pages (from-to)	796-804
Number of pages	9
ISSN	0149-5992
DOIs	https://doi.org/10.2337/dc13-0598
Publication status	Published - Mar 2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.2337/dc13-0598

Cite this

Møller, J. B., Pedersen, M., Tanaka, H., Ohsugi, M., Overgaard, R. V., Lynge, J., Almind, K., Vasconcelos, N-M., Poulsen, P., Keller, C., Ueki, K., Ingwersen, S. H., Pedersen, B. K., & Kadowaki, T. (2014). Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians. Diabetes Care, 37(3), 796-804. https://doi.org/10.2337/dc13-0598

Møller, JB, Pedersen, M, Tanaka, H, Ohsugi, M, Overgaard, RV, Lynge, J, Almind, K, Vasconcelos, N-M, Poulsen, P, Keller, C, Ueki, K, Ingwersen, SH, Pedersen, BK & Kadowaki, T 2014, 'Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians', Diabetes Care, vol. 37, no. 3, pp. 796-804. https://doi.org/10.2337/dc13-0598

@article{c33368c3e5bd42a0b45b5d1363a5ec6c,

title = "Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians",

abstract = "OBJECTIVE This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and b-cell response. RESEARCH DESIGN AND METHODS A total of 120 Japanese and 150 Caucasians were enrolled to obtain comparable distributions of high/low BMI values across glucose tolerance states (normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes), which were assessed by oral glucose tolerance tests. BMI in the two cohorts was distributed around the two regional cutoff values for obesity. RESULTS Insulin sensitivity was higher in Japanese compared with Caucasians, as indicated by the homeostatic model assessment of insulin resistance and Matsuda indices, whereas b-cell response was higher in Caucasians, as measured by homeostatic model assessment of b-cell function, the insulinogenic indices, and insulin secretion ratios. Disposition indices were similar for Japanese and Caucasians at all glucose tolerance states, indicating similar b-cell response relative to the degree of insulin resistance. The main determinants for differences in metabolic indices were measures of body composition, such as BMI and distribution of adipose tissue. Differences in b-cell response between Japanese and Caucasians were not statistically significant following adjustment by differences in BMI. CONCLUSIONS Our study showed similar disposition indices in Japanese and Caucasians and that themajor part of the differences in insulin sensitivity and b-cell response between Japanese and Caucasians can be explained by differences in body composition.",

author = "M{\o}ller, {Jonas B} and Maria Pedersen and Haruhiko Tanaka and Mitsuru Ohsugi and Overgaard, {Rune V} and Jan Lynge and Katrine Almind and Nina-Maria Vasconcelos and Pernille Poulsen and Charlotte Keller and Kohjiro Ueki and Ingwersen, {Steen H} and Pedersen, {Bente K} and Takashi Kadowaki",

year = "2014",

month = mar,

doi = "10.2337/dc13-0598",

language = "English",

volume = "37",

pages = "796--804",

journal = "Diabetes Care",

issn = "0149-5992",

publisher = "American Diabetes Association",

number = "3",

}

TY - JOUR

T1 - Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians

AU - Møller, Jonas B

AU - Pedersen, Maria

AU - Tanaka, Haruhiko

AU - Ohsugi, Mitsuru

AU - Overgaard, Rune V

AU - Lynge, Jan

AU - Almind, Katrine

AU - Vasconcelos, Nina-Maria

AU - Poulsen, Pernille

AU - Keller, Charlotte

AU - Ueki, Kohjiro

AU - Ingwersen, Steen H

AU - Pedersen, Bente K

AU - Kadowaki, Takashi

PY - 2014/3

Y1 - 2014/3

N2 - OBJECTIVE This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and b-cell response. RESEARCH DESIGN AND METHODS A total of 120 Japanese and 150 Caucasians were enrolled to obtain comparable distributions of high/low BMI values across glucose tolerance states (normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes), which were assessed by oral glucose tolerance tests. BMI in the two cohorts was distributed around the two regional cutoff values for obesity. RESULTS Insulin sensitivity was higher in Japanese compared with Caucasians, as indicated by the homeostatic model assessment of insulin resistance and Matsuda indices, whereas b-cell response was higher in Caucasians, as measured by homeostatic model assessment of b-cell function, the insulinogenic indices, and insulin secretion ratios. Disposition indices were similar for Japanese and Caucasians at all glucose tolerance states, indicating similar b-cell response relative to the degree of insulin resistance. The main determinants for differences in metabolic indices were measures of body composition, such as BMI and distribution of adipose tissue. Differences in b-cell response between Japanese and Caucasians were not statistically significant following adjustment by differences in BMI. CONCLUSIONS Our study showed similar disposition indices in Japanese and Caucasians and that themajor part of the differences in insulin sensitivity and b-cell response between Japanese and Caucasians can be explained by differences in body composition.

AB - OBJECTIVE This cross-sectional clinical study compared the pathophysiology of type 2 diabetes in Japanese and Caucasians and investigated the role of demographic, genetic, and lifestyle-related risk factors for insulin resistance and b-cell response. RESEARCH DESIGN AND METHODS A total of 120 Japanese and 150 Caucasians were enrolled to obtain comparable distributions of high/low BMI values across glucose tolerance states (normal glucose tolerance, impaired glucose tolerance, and type 2 diabetes), which were assessed by oral glucose tolerance tests. BMI in the two cohorts was distributed around the two regional cutoff values for obesity. RESULTS Insulin sensitivity was higher in Japanese compared with Caucasians, as indicated by the homeostatic model assessment of insulin resistance and Matsuda indices, whereas b-cell response was higher in Caucasians, as measured by homeostatic model assessment of b-cell function, the insulinogenic indices, and insulin secretion ratios. Disposition indices were similar for Japanese and Caucasians at all glucose tolerance states, indicating similar b-cell response relative to the degree of insulin resistance. The main determinants for differences in metabolic indices were measures of body composition, such as BMI and distribution of adipose tissue. Differences in b-cell response between Japanese and Caucasians were not statistically significant following adjustment by differences in BMI. CONCLUSIONS Our study showed similar disposition indices in Japanese and Caucasians and that themajor part of the differences in insulin sensitivity and b-cell response between Japanese and Caucasians can be explained by differences in body composition.

U2 - 10.2337/dc13-0598

DO - 10.2337/dc13-0598

M3 - Journal article

C2 - 24130359

SN - 0149-5992

VL - 37

SP - 796

EP - 804

JO - Diabetes Care

JF - Diabetes Care

IS - 3

ER -

Body Composition Is the Main Determinant for the Difference in Type 2 Diabetes Pathophysiology Between Japanese and Caucasians

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this