Body composition growth patterns in early infancy: A latent class trajectory analysis of the Ethiopian iABC Birth Cohort

TY - JOUR

T1 - Body composition growth patterns in early infancy

T2 - A latent class trajectory analysis of the Ethiopian iABC Birth Cohort

AU - Andersen, Gregers Stig

AU - Wibæk Christensen, Rasmus

AU - Kaestel, Pernille

AU - Girma, Tsinuel

AU - Admassu, Bitiya

AU - Abera, Mubarek

AU - Vistisen, Dorte

AU - Jørgensen, Marit Eika

AU - Michaelsen, Kim F.

AU - Friis, Henrik

AU - Wells, Jonathan C K

N1 - CURIS 2018 NEXS 182

PY - 2018/7

Y1 - 2018/7

N2 - Objective: The objective of this study was to identify subgroups with distinct fat and fat-free growth patterns in the first 6 months of life and describe predictors of these different patterns.Methods: A total of 510 apparently healthy Ethiopian infants were followed from birth to 6 months of age. Each infant had at least three and up to six repeated measurements of fat and fat-free mass using air-displacement plethysmography. Latent class trajectory analyses were used to categorize infants in groups with distinct body composition patterns.Results: Four distinct fat mass and two fat-free mass growth patterns were identified. Of the infants measured, 5% presented a delayed fat growth pattern and 3% presented a catch-up fat growth pattern involving low birth weight but a significant fat growth velocity from 2.5 to 6 months. A large class had a high fat level at birth and an accelerated fat growth pattern in early infancy. Fat-free growth was represented by two distinct classes with less variability. Catch-up growth was primarily seen in fat mass.Conclusions: We identified distinct patterns of delayed, catch-up, and accelerated fat growth in early infancy. This variability is not detected in regular anthropometric assessment and could be a mechanism linking early growth with later obesity and cardiometabolic risk.

AB - Objective: The objective of this study was to identify subgroups with distinct fat and fat-free growth patterns in the first 6 months of life and describe predictors of these different patterns.Methods: A total of 510 apparently healthy Ethiopian infants were followed from birth to 6 months of age. Each infant had at least three and up to six repeated measurements of fat and fat-free mass using air-displacement plethysmography. Latent class trajectory analyses were used to categorize infants in groups with distinct body composition patterns.Results: Four distinct fat mass and two fat-free mass growth patterns were identified. Of the infants measured, 5% presented a delayed fat growth pattern and 3% presented a catch-up fat growth pattern involving low birth weight but a significant fat growth velocity from 2.5 to 6 months. A large class had a high fat level at birth and an accelerated fat growth pattern in early infancy. Fat-free growth was represented by two distinct classes with less variability. Catch-up growth was primarily seen in fat mass.Conclusions: We identified distinct patterns of delayed, catch-up, and accelerated fat growth in early infancy. This variability is not detected in regular anthropometric assessment and could be a mechanism linking early growth with later obesity and cardiometabolic risk.

U2 - 10.1002/oby.22197

DO - 10.1002/oby.22197

M3 - Journal article

C2 - 29845756

SN - 1930-7381

VL - 26

SP - 1225

EP - 1233

JO - Obesity

JF - Obesity

IS - 7

ER -