BNP and N-terminal proBNP are both extracted in the normal kidney

J P Goetze; G Jensen; S Møller; F Bendtsen; J F Rehfeld; Jens Henrik Sahl Henriksen; Jens Peter Gøtze; Gorm Boje Jensen; Søren Møller; Flemming Bendtsen; Jens Fr. Rehfeld; Jens Henrik Henriksen

doi:10.1111/j.1365-2362.2006.01594.x

BNP and N-terminal proBNP are both extracted in the normal kidney

J P Goetze, G Jensen, S Møller, F Bendtsen, J F Rehfeld, Jens Henrik Sahl Henriksen, Jens Peter Gøtze, Gorm Boje Jensen, Søren Møller, Flemming Bendtsen, Jens Fr. Rehfeld, Jens Henrik Henriksen

73 Citations (Scopus)

Abstract

BACKGROUND: Increased plasma concentrations of cardiac-derived B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (proBNP) are both associated with left ventricular dysfunction. Information on the regional elimination of the peptides is, however, still scarce. We therefore examined the renal and peripheral extraction of N-terminal proBNP and BNP. MATERIALS AND METHODS: The study comprised 18 patients with essential arterial hypertension, 51 with cirrhosis, and 18 control patients without kidney or liver disease. All patients underwent a haemodynamic investigation with catheterization of the femoral artery and femoral and renal veins. Blood sampling from the catheters allowed determination of the arteriovenous extraction ratio of N-terminal proBNP and BNP. RESULTS: Neither the peripheral N-terminal proBNP (13, 11, 19 pmol L(-1), NS) nor the BNP plasma concentrations (4, 12, 9 pmol L(-1), NS) differed between the patient groups. In addition, similar renal extractions were observed in the groups. The renal extraction of N-terminal proBNP (0.16) was not different from that of BNP (0.16). In contrast, the N-terminal proBNP extraction in the lower extremity was markedly lower compared with BNP (0.00 vs. 0.125, P = 0.007). CONCLUSIONS: A comparable renal elimination of N-terminal proBNP and BNP is contrasted by a selective extraction of BNP in the lower extremity. Our results suggest a different elimination mechanism in the renal and peripheral circulation, which partly may explain the higher N-terminal proBNP compared with BNP concentrations in normal plasma.

Original language	English
Journal	European Journal of Clinical Investigation
Volume	36
Issue number	1
Pages (from-to)	8-15
Number of pages	8
ISSN	0014-2972
DOIs	https://doi.org/10.1111/j.1365-2362.2006.01594.x
Publication status	Published - 2006

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10.1111/j.1365-2362.2006.01594.x

http://www.blackwell-synergy.com/doi/abs/10.1111/j.1365-2362.2006.01594.x

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@article{621cc6f01bc311df8ed1000ea68e967b,

title = "BNP and N-terminal proBNP are both extracted in the normal kidney",

abstract = "BACKGROUND: Increased plasma concentrations of cardiac-derived B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (proBNP) are both associated with left ventricular dysfunction. Information on the regional elimination of the peptides is, however, still scarce. We therefore examined the renal and peripheral extraction of N-terminal proBNP and BNP. MATERIALS AND METHODS: The study comprised 18 patients with essential arterial hypertension, 51 with cirrhosis, and 18 control patients without kidney or liver disease. All patients underwent a haemodynamic investigation with catheterization of the femoral artery and femoral and renal veins. Blood sampling from the catheters allowed determination of the arteriovenous extraction ratio of N-terminal proBNP and BNP. RESULTS: Neither the peripheral N-terminal proBNP (13, 11, 19 pmol L(-1), NS) nor the BNP plasma concentrations (4, 12, 9 pmol L(-1), NS) differed between the patient groups. In addition, similar renal extractions were observed in the groups. The renal extraction of N-terminal proBNP (0.16) was not different from that of BNP (0.16). In contrast, the N-terminal proBNP extraction in the lower extremity was markedly lower compared with BNP (0.00 vs. 0.125, P = 0.007). CONCLUSIONS: A comparable renal elimination of N-terminal proBNP and BNP is contrasted by a selective extraction of BNP in the lower extremity. Our results suggest a different elimination mechanism in the renal and peripheral circulation, which partly may explain the higher N-terminal proBNP compared with BNP concentrations in normal plasma.",

author = "Goetze, {J P} and G Jensen and S M{\o}ller and F Bendtsen and Rehfeld, {J F} and Henriksen, {Jens Henrik Sahl} and G{\o}tze, {Jens Peter} and Jensen, {Gorm Boje} and S{\o}ren M{\o}ller and Flemming Bendtsen and Rehfeld, {Jens Fr.} and Henriksen, {Jens Henrik}",

note = "Keywords: Aged; Biological Markers; Female; Hemodynamics; Humans; Hypertension; Kidney; Liver Cirrhosis; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments",

year = "2006",

doi = "10.1111/j.1365-2362.2006.01594.x",

language = "English",

volume = "36",

pages = "8--15",

journal = "European Journal of Clinical Investigation",

issn = "0014-2972",

publisher = "Wiley-Blackwell",

number = "1",

}

TY - JOUR

T1 - BNP and N-terminal proBNP are both extracted in the normal kidney

AU - Goetze, J P

AU - Jensen, G

AU - Møller, S

AU - Bendtsen, F

AU - Rehfeld, J F

AU - Henriksen, Jens Henrik Sahl

AU - Gøtze, Jens Peter

AU - Jensen, Gorm Boje

AU - Møller, Søren

AU - Bendtsen, Flemming

AU - Rehfeld, Jens Fr.

AU - Henriksen, Jens Henrik

N1 - Keywords: Aged; Biological Markers; Female; Hemodynamics; Humans; Hypertension; Kidney; Liver Cirrhosis; Male; Middle Aged; Natriuretic Peptide, Brain; Peptide Fragments

PY - 2006

Y1 - 2006

N2 - BACKGROUND: Increased plasma concentrations of cardiac-derived B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (proBNP) are both associated with left ventricular dysfunction. Information on the regional elimination of the peptides is, however, still scarce. We therefore examined the renal and peripheral extraction of N-terminal proBNP and BNP. MATERIALS AND METHODS: The study comprised 18 patients with essential arterial hypertension, 51 with cirrhosis, and 18 control patients without kidney or liver disease. All patients underwent a haemodynamic investigation with catheterization of the femoral artery and femoral and renal veins. Blood sampling from the catheters allowed determination of the arteriovenous extraction ratio of N-terminal proBNP and BNP. RESULTS: Neither the peripheral N-terminal proBNP (13, 11, 19 pmol L(-1), NS) nor the BNP plasma concentrations (4, 12, 9 pmol L(-1), NS) differed between the patient groups. In addition, similar renal extractions were observed in the groups. The renal extraction of N-terminal proBNP (0.16) was not different from that of BNP (0.16). In contrast, the N-terminal proBNP extraction in the lower extremity was markedly lower compared with BNP (0.00 vs. 0.125, P = 0.007). CONCLUSIONS: A comparable renal elimination of N-terminal proBNP and BNP is contrasted by a selective extraction of BNP in the lower extremity. Our results suggest a different elimination mechanism in the renal and peripheral circulation, which partly may explain the higher N-terminal proBNP compared with BNP concentrations in normal plasma.

AB - BACKGROUND: Increased plasma concentrations of cardiac-derived B-type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (proBNP) are both associated with left ventricular dysfunction. Information on the regional elimination of the peptides is, however, still scarce. We therefore examined the renal and peripheral extraction of N-terminal proBNP and BNP. MATERIALS AND METHODS: The study comprised 18 patients with essential arterial hypertension, 51 with cirrhosis, and 18 control patients without kidney or liver disease. All patients underwent a haemodynamic investigation with catheterization of the femoral artery and femoral and renal veins. Blood sampling from the catheters allowed determination of the arteriovenous extraction ratio of N-terminal proBNP and BNP. RESULTS: Neither the peripheral N-terminal proBNP (13, 11, 19 pmol L(-1), NS) nor the BNP plasma concentrations (4, 12, 9 pmol L(-1), NS) differed between the patient groups. In addition, similar renal extractions were observed in the groups. The renal extraction of N-terminal proBNP (0.16) was not different from that of BNP (0.16). In contrast, the N-terminal proBNP extraction in the lower extremity was markedly lower compared with BNP (0.00 vs. 0.125, P = 0.007). CONCLUSIONS: A comparable renal elimination of N-terminal proBNP and BNP is contrasted by a selective extraction of BNP in the lower extremity. Our results suggest a different elimination mechanism in the renal and peripheral circulation, which partly may explain the higher N-terminal proBNP compared with BNP concentrations in normal plasma.

U2 - 10.1111/j.1365-2362.2006.01594.x

DO - 10.1111/j.1365-2362.2006.01594.x

M3 - Journal article

C2 - 16403004

SN - 0014-2972

VL - 36

SP - 8

EP - 15

JO - European Journal of Clinical Investigation

JF - European Journal of Clinical Investigation

IS - 1

ER -

BNP and N-terminal proBNP are both extracted in the normal kidney

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