BMD PREDICTION OF DEATH IS ENCAPSULATED BY THE MORPHOLOGICAL ATHEROSCLEROSIS CALCIFICATION DISTRIBUTION (MACD) INDEX

TY - ABST

T1 - BMD PREDICTION OF DEATH IS ENCAPSULATED BY THE MORPHOLOGICAL ATHEROSCLEROSIS CALCIFICATION DISTRIBUTION (MACD) INDEX

AU - Ganz, Melanie

AU - Nielsen, Mads

AU - Karsdal, Morten

AU - Christiansen, Claus

N1 - Conference code: 36

PY - 2009

Y1 - 2009

N2 - Background: We investigate the relation between the BMD and the aortic calcification markers AC24 and MACD, triglyceride level, cholesterol level, waist-to-hip ratio and the incidence of cardiovascular death. Methods: Our population consists of 308 women aged 48 to 76 that were followed for 8.3±0.3 years and of which CVD, cancer, and all cause deaths were recorded. The spine BMD and aortic calcification markers, AC24 and the recently proposed Morphological Atherosclerosis Calcification Distribution (MACD) index, were quantified from DXA scans and lateral X-rays respectively. The MACD is constructed to capture the risk of death from the outline of aortic calcifications, and not just from the amount of calcification quantified by the AC24. The relation to death was analysed using markers adjusted for age, triglyceride level, and waist circumference (ATW adjusted). A student's t-test of group mean differences was used. Marker correlations were analysed with Pearson's R2 and its significance of being different from zero. Significance levels were denoted as: *(p<0.05), ** (p<0.01), *** (p<0.001). Results: 52 women died (20 CVD, 27 Cancer, 5 othercauses) during the observation time. The BMD was lower in the CVD death group and even lower in the cancer death group. The BMD correlated negatively with the calcification markers in the group of survivors (Table 1). In the group of CVD death, AC24 correlated positively with BMD and was still significantly correlated after adjustment for ATW. Conclusion: In general, the BMD decreased with age and calcification and may constitute an all cause risk factor independently from ATW. The AC24 showed a dependency on BMD for the CVD deceased, whereas MACD did not. This may be interpreted as the MACD already including the potential risk segregation of BMD. Hence, including BMD in a risk assessment may help timely referral and save lives in conjunction with the current AC24 calcification scoring, but does not improve the MACD index

AB - Background: We investigate the relation between the BMD and the aortic calcification markers AC24 and MACD, triglyceride level, cholesterol level, waist-to-hip ratio and the incidence of cardiovascular death. Methods: Our population consists of 308 women aged 48 to 76 that were followed for 8.3±0.3 years and of which CVD, cancer, and all cause deaths were recorded. The spine BMD and aortic calcification markers, AC24 and the recently proposed Morphological Atherosclerosis Calcification Distribution (MACD) index, were quantified from DXA scans and lateral X-rays respectively. The MACD is constructed to capture the risk of death from the outline of aortic calcifications, and not just from the amount of calcification quantified by the AC24. The relation to death was analysed using markers adjusted for age, triglyceride level, and waist circumference (ATW adjusted). A student's t-test of group mean differences was used. Marker correlations were analysed with Pearson's R2 and its significance of being different from zero. Significance levels were denoted as: *(p<0.05), ** (p<0.01), *** (p<0.001). Results: 52 women died (20 CVD, 27 Cancer, 5 othercauses) during the observation time. The BMD was lower in the CVD death group and even lower in the cancer death group. The BMD correlated negatively with the calcification markers in the group of survivors (Table 1). In the group of CVD death, AC24 correlated positively with BMD and was still significantly correlated after adjustment for ATW. Conclusion: In general, the BMD decreased with age and calcification and may constitute an all cause risk factor independently from ATW. The AC24 showed a dependency on BMD for the CVD deceased, whereas MACD did not. This may be interpreted as the MACD already including the potential risk segregation of BMD. Hence, including BMD in a risk assessment may help timely referral and save lives in conjunction with the current AC24 calcification scoring, but does not improve the MACD index

U2 - 10.1016/j.bone.2009.03.460

DO - 10.1016/j.bone.2009.03.460

M3 - Conference abstract in journal

SN - 8756-3282

SP - S265

JO - Bone

JF - Bone

IS - suppl. 2

T2 - 36th European Symposium on Calcified Tissues

Y2 - 23 May 2009 through 27 May 2009

ER -