Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study

Morten Dahl; Anne Tybjaerg-Hansen; Henrik Sillesen; Gorm Jensen; Rolf Steffensen; Børge G Nordestgaard

Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study

Morten Dahl, Anne Tybjaerg-Hansen, Henrik Sillesen, Gorm Jensen, Rolf Steffensen, Børge G Nordestgaard

Department of Clinical Medicine

31 Citations (Scopus)

Abstract

Because elastase in alpha(1)-antitrypsin deficiency may attack elastin in the arterial wall, we tested whether alpha(1)-antitrypsin deficiency is associated with reduced blood pressure, risk of ischemic cerebrovascular (ICVD) and ischemic heart disease (IHD), and longevity.

Original language	English
Journal	Circulation
Volume	107
Issue number	5
Pages (from-to)	747-52
Number of pages	6
ISSN	0009-7322
Publication status	Published - 11 Feb 2003

Keywords

Adult
Age Distribution
Aged
Aged, 80 and over
Blood Pressure
Brain Ischemia
Comorbidity
Denmark
Female
Gene Frequency
Genetic Testing
Genotype
Homozygote
Humans
Logistic Models
Male
Middle Aged
Myocardial Ischemia
Odds Ratio
Polymorphism, Genetic
Reference Values
Risk Assessment
alpha 1-Antitrypsin Deficiency

Cite this

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title = "Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study",

abstract = "Because elastase in alpha(1)-antitrypsin deficiency may attack elastin in the arterial wall, we tested whether alpha(1)-antitrypsin deficiency is associated with reduced blood pressure, risk of ischemic cerebrovascular (ICVD) and ischemic heart disease (IHD), and longevity.",

keywords = "Adult, Age Distribution, Aged, Aged, 80 and over, Blood Pressure, Brain Ischemia, Comorbidity, Denmark, Female, Gene Frequency, Genetic Testing, Genotype, Homozygote, Humans, Logistic Models, Male, Middle Aged, Myocardial Ischemia, Odds Ratio, Polymorphism, Genetic, Reference Values, Risk Assessment, alpha 1-Antitrypsin Deficiency",

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T1 - Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency

T2 - the Copenhagen City Heart Study

AU - Dahl, Morten

AU - Tybjaerg-Hansen, Anne

AU - Sillesen, Henrik

AU - Jensen, Gorm

AU - Steffensen, Rolf

AU - Nordestgaard, Børge G

PY - 2003/2/11

Y1 - 2003/2/11

N2 - Because elastase in alpha(1)-antitrypsin deficiency may attack elastin in the arterial wall, we tested whether alpha(1)-antitrypsin deficiency is associated with reduced blood pressure, risk of ischemic cerebrovascular (ICVD) and ischemic heart disease (IHD), and longevity.

AB - Because elastase in alpha(1)-antitrypsin deficiency may attack elastin in the arterial wall, we tested whether alpha(1)-antitrypsin deficiency is associated with reduced blood pressure, risk of ischemic cerebrovascular (ICVD) and ischemic heart disease (IHD), and longevity.

KW - Adult

KW - Age Distribution

KW - Aged

KW - Aged, 80 and over

KW - Blood Pressure

KW - Brain Ischemia

KW - Comorbidity

KW - Denmark

KW - Female

KW - Gene Frequency

KW - Genetic Testing

KW - Genotype

KW - Homozygote

KW - Humans

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia

KW - Odds Ratio

KW - Polymorphism, Genetic

KW - Reference Values

KW - Risk Assessment

KW - alpha 1-Antitrypsin Deficiency

M3 - Journal article

C2 - 12578879

SN - 0009-7322

VL - 107

SP - 747

EP - 752

JO - Circulation

JF - Circulation

IS - 5

ER -

Blood pressure, risk of ischemic cerebrovascular and ischemic heart disease, and longevity in alpha(1)-antitrypsin deficiency: the Copenhagen City Heart Study

Abstract

Keywords

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