Blood cell generation from the hemangioblast

Christophe Lancrin; Patrycja Sroczynska; Alicia G Serrano; Arnaud Gandillet; Cristina Ferreras; Valerie Kouskoff; Georges Lacaud

doi:10.1007/s00109-009-0554-0

Blood cell generation from the hemangioblast

Christophe Lancrin, Patrycja Sroczynska, Alicia G Serrano, Arnaud Gandillet, Cristina Ferreras, Valerie Kouskoff, Georges Lacaud

54 Citations (Scopus)

Abstract

Understanding how blood cells are generated is important from a biological perspective but also has potential implications in the treatment of blood diseases. Such knowledge could potentially lead to defining new conditions to amplify hematopoietic stem cells (HSCs) or could translate into new methods to produce HSCs, or other types of blood cells, from human embryonic stem cells or induced pluripotent stem cells. Additionally, as most key transcription factors regulating early hematopoietic development have also been implicated in various types of leukemia, understanding their function during normal development could result in a better comprehension of their roles during abnormal hematopoiesis in leukemia. In this review, we discuss our current understanding of the molecular and cellular mechanisms of blood development from the earliest hematopoietic precursor, the hemangioblast, a precursor for both endothelial and hematopoietic cell lineages.

Original language	English
Journal	Journal of Molecular Medicine
Volume	88
Issue number	2
Pages (from-to)	167-72
Number of pages	6
ISSN	0946-2716
DOIs	https://doi.org/10.1007/s00109-009-0554-0
Publication status	Published - 1 Feb 2010
Externally published	Yes

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abstract = "Understanding how blood cells are generated is important from a biological perspective but also has potential implications in the treatment of blood diseases. Such knowledge could potentially lead to defining new conditions to amplify hematopoietic stem cells (HSCs) or could translate into new methods to produce HSCs, or other types of blood cells, from human embryonic stem cells or induced pluripotent stem cells. Additionally, as most key transcription factors regulating early hematopoietic development have also been implicated in various types of leukemia, understanding their function during normal development could result in a better comprehension of their roles during abnormal hematopoiesis in leukemia. In this review, we discuss our current understanding of the molecular and cellular mechanisms of blood development from the earliest hematopoietic precursor, the hemangioblast, a precursor for both endothelial and hematopoietic cell lineages.",

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T1 - Blood cell generation from the hemangioblast

AU - Lancrin, Christophe

AU - Sroczynska, Patrycja

AU - Serrano, Alicia G

AU - Gandillet, Arnaud

AU - Ferreras, Cristina

AU - Kouskoff, Valerie

AU - Lacaud, Georges

PY - 2010/2/1

Y1 - 2010/2/1

N2 - Understanding how blood cells are generated is important from a biological perspective but also has potential implications in the treatment of blood diseases. Such knowledge could potentially lead to defining new conditions to amplify hematopoietic stem cells (HSCs) or could translate into new methods to produce HSCs, or other types of blood cells, from human embryonic stem cells or induced pluripotent stem cells. Additionally, as most key transcription factors regulating early hematopoietic development have also been implicated in various types of leukemia, understanding their function during normal development could result in a better comprehension of their roles during abnormal hematopoiesis in leukemia. In this review, we discuss our current understanding of the molecular and cellular mechanisms of blood development from the earliest hematopoietic precursor, the hemangioblast, a precursor for both endothelial and hematopoietic cell lineages.

AB - Understanding how blood cells are generated is important from a biological perspective but also has potential implications in the treatment of blood diseases. Such knowledge could potentially lead to defining new conditions to amplify hematopoietic stem cells (HSCs) or could translate into new methods to produce HSCs, or other types of blood cells, from human embryonic stem cells or induced pluripotent stem cells. Additionally, as most key transcription factors regulating early hematopoietic development have also been implicated in various types of leukemia, understanding their function during normal development could result in a better comprehension of their roles during abnormal hematopoiesis in leukemia. In this review, we discuss our current understanding of the molecular and cellular mechanisms of blood development from the earliest hematopoietic precursor, the hemangioblast, a precursor for both endothelial and hematopoietic cell lineages.

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VL - 88

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JO - Journal of Molecular Medicine

JF - Journal of Molecular Medicine

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Blood cell generation from the hemangioblast

Abstract

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