Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Karen Cecilie Duus Thestrup; Vibeke Logager; Ingerd Baslev; Jakob M Møller; Rasmus Hvass Hansen; Henrik S Thomsen

doi:10.1177/2058460116663046

Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Karen Cecilie Duus Thestrup, Vibeke Logager, Ingerd Baslev, Jakob M Møller, Rasmus Hvass Hansen, Henrik S Thomsen

Department of Clinical Medicine

Abstract

BACKGROUND: Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis.

PURPOSE: To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa.

MATERIAL AND METHODS: A total of 204 men (median age, 65 years; mean ± SD, 64.1; range 45-75 years; median serum PSA level, 14 ng/mL; range, 2.2-120 ng/mL; median prostate volume, 60 mL; range, 23-263 mL) fulfilled the criteria for being enrolled. They underwent mp-MRI and prostate biopsy from January through June 2014. Of the included patients, 9.3% underwent prostatectomy, 90.7% had TRUS-bx, and 10.8 had MRI-targeted TRUS-bx. Two radiologists separately assessed the mp-MRI examination (T2-weighted [T2W] imaging, diffusion-weighted imaging [DWI], apparent diffusion coefficient map [ADC-map] and dynamic contrast-enhanced imaging [DCE]). Two months later, the bp-MRI version (T2W imaging, DWI, and ADC-map) was evaluated.

RESULTS: Reader 1: Assessing mp-MRI: 0 false negatives, sensitivity of 1, and specificity 0.04. Assessing bp-MRI: four false negatives, sensitivity of 0.94, and specificity 0.15. Reader 2: Assessing mp-MRI: five false negatives, sensitivity of 0.93, and specificity 0.16. Assessing bp-MRI: three false negatives, sensitivity of 0.96, and specificity 0.15. Intra-reader agreement Cohen's Kappa (κ) was 0.87 for reader 1 (95% confidence interval [CI], 0.83-0.92) and 0.84 for reader 2 (95% CI 0.78-0.89).

CONCLUSION: Bp-MRI is as good as mp-MRI at detecting PCa. A large prospective study seems to be strongly warranted.

Original language	English
Article number	2058460116663046
Journal	Acta Radiologica Open
Volume	5
Issue number	8
Number of pages	8
ISSN	2058-4601
DOIs	https://doi.org/10.1177/2058460116663046
Publication status	Published - 2016

Keywords

Journal Article

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1177/2058460116663046Licence: CC BY-NC

Cite this

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title = "Biparametric versus multiparametric MRI in the diagnosis of prostate cancer",

abstract = "BACKGROUND: Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis.PURPOSE: To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa.MATERIAL AND METHODS: A total of 204 men (median age, 65 years; mean ± SD, 64.1; range 45-75 years; median serum PSA level, 14 ng/mL; range, 2.2-120 ng/mL; median prostate volume, 60 mL; range, 23-263 mL) fulfilled the criteria for being enrolled. They underwent mp-MRI and prostate biopsy from January through June 2014. Of the included patients, 9.3% underwent prostatectomy, 90.7% had TRUS-bx, and 10.8 had MRI-targeted TRUS-bx. Two radiologists separately assessed the mp-MRI examination (T2-weighted [T2W] imaging, diffusion-weighted imaging [DWI], apparent diffusion coefficient map [ADC-map] and dynamic contrast-enhanced imaging [DCE]). Two months later, the bp-MRI version (T2W imaging, DWI, and ADC-map) was evaluated.RESULTS: Reader 1: Assessing mp-MRI: 0 false negatives, sensitivity of 1, and specificity 0.04. Assessing bp-MRI: four false negatives, sensitivity of 0.94, and specificity 0.15. Reader 2: Assessing mp-MRI: five false negatives, sensitivity of 0.93, and specificity 0.16. Assessing bp-MRI: three false negatives, sensitivity of 0.96, and specificity 0.15. Intra-reader agreement Cohen's Kappa (κ) was 0.87 for reader 1 (95% confidence interval [CI], 0.83-0.92) and 0.84 for reader 2 (95% CI 0.78-0.89).CONCLUSION: Bp-MRI is as good as mp-MRI at detecting PCa. A large prospective study seems to be strongly warranted.",

keywords = "Journal Article",

author = "Thestrup, {Karen Cecilie Duus} and Vibeke Logager and Ingerd Baslev and M{\o}ller, {Jakob M} and Hansen, {Rasmus Hvass} and Thomsen, {Henrik S}",

year = "2016",

doi = "10.1177/2058460116663046",

language = "English",

volume = "5",

journal = "Acta Radiologica Open",

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T1 - Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

AU - Thestrup, Karen Cecilie Duus

AU - Logager, Vibeke

AU - Baslev, Ingerd

AU - Møller, Jakob M

AU - Hansen, Rasmus Hvass

AU - Thomsen, Henrik S

PY - 2016

Y1 - 2016

N2 - BACKGROUND: Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis.PURPOSE: To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa.MATERIAL AND METHODS: A total of 204 men (median age, 65 years; mean ± SD, 64.1; range 45-75 years; median serum PSA level, 14 ng/mL; range, 2.2-120 ng/mL; median prostate volume, 60 mL; range, 23-263 mL) fulfilled the criteria for being enrolled. They underwent mp-MRI and prostate biopsy from January through June 2014. Of the included patients, 9.3% underwent prostatectomy, 90.7% had TRUS-bx, and 10.8 had MRI-targeted TRUS-bx. Two radiologists separately assessed the mp-MRI examination (T2-weighted [T2W] imaging, diffusion-weighted imaging [DWI], apparent diffusion coefficient map [ADC-map] and dynamic contrast-enhanced imaging [DCE]). Two months later, the bp-MRI version (T2W imaging, DWI, and ADC-map) was evaluated.RESULTS: Reader 1: Assessing mp-MRI: 0 false negatives, sensitivity of 1, and specificity 0.04. Assessing bp-MRI: four false negatives, sensitivity of 0.94, and specificity 0.15. Reader 2: Assessing mp-MRI: five false negatives, sensitivity of 0.93, and specificity 0.16. Assessing bp-MRI: three false negatives, sensitivity of 0.96, and specificity 0.15. Intra-reader agreement Cohen's Kappa (κ) was 0.87 for reader 1 (95% confidence interval [CI], 0.83-0.92) and 0.84 for reader 2 (95% CI 0.78-0.89).CONCLUSION: Bp-MRI is as good as mp-MRI at detecting PCa. A large prospective study seems to be strongly warranted.

AB - BACKGROUND: Since multiparametric magnetic resonance imaging (mp-MRI) of the prostate exceeds 30 min, minimizing the evaluation time of significant (Gleason scores > 6) prostate cancer (PCa) would be beneficial. A reduced protocol might be sufficient for the diagnosis.PURPOSE: To study whether a short unenhanced biparametric MRI (bp-MRI) matches mp-MRI in detecting significant PCa.MATERIAL AND METHODS: A total of 204 men (median age, 65 years; mean ± SD, 64.1; range 45-75 years; median serum PSA level, 14 ng/mL; range, 2.2-120 ng/mL; median prostate volume, 60 mL; range, 23-263 mL) fulfilled the criteria for being enrolled. They underwent mp-MRI and prostate biopsy from January through June 2014. Of the included patients, 9.3% underwent prostatectomy, 90.7% had TRUS-bx, and 10.8 had MRI-targeted TRUS-bx. Two radiologists separately assessed the mp-MRI examination (T2-weighted [T2W] imaging, diffusion-weighted imaging [DWI], apparent diffusion coefficient map [ADC-map] and dynamic contrast-enhanced imaging [DCE]). Two months later, the bp-MRI version (T2W imaging, DWI, and ADC-map) was evaluated.RESULTS: Reader 1: Assessing mp-MRI: 0 false negatives, sensitivity of 1, and specificity 0.04. Assessing bp-MRI: four false negatives, sensitivity of 0.94, and specificity 0.15. Reader 2: Assessing mp-MRI: five false negatives, sensitivity of 0.93, and specificity 0.16. Assessing bp-MRI: three false negatives, sensitivity of 0.96, and specificity 0.15. Intra-reader agreement Cohen's Kappa (κ) was 0.87 for reader 1 (95% confidence interval [CI], 0.83-0.92) and 0.84 for reader 2 (95% CI 0.78-0.89).CONCLUSION: Bp-MRI is as good as mp-MRI at detecting PCa. A large prospective study seems to be strongly warranted.

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DO - 10.1177/2058460116663046

M3 - Journal article

C2 - 27583170

SN - 2058-4601

VL - 5

JO - Acta Radiologica Open

JF - Acta Radiologica Open

IS - 8

M1 - 2058460116663046

ER -

Biparametric versus multiparametric MRI in the diagnosis of prostate cancer

Abstract

Keywords

UN SDGs

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