Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016: a collaboration between five biological registries

B. Glintborg; U. Lindström; K. Aaltonen; E. K. Kristianslund; B. Gudbjornsson; K. Chatzidionysiou; J. Askling; D. Nordström; M. L. Hetland; D. Di Giuseppe; L. Dreyer; L. E. Kristensen; T. S. Jørgensen; K. Eklund; G. Grondal; S. Ernestam; J. Joensuu; M. R.K. Törmänen; H. Skydsgaard; J. Hagfors; T. K. Kvien; E. Lie; K. Fagerli; A. J. Geirsson; H. Jonsson; S. A. Provan; N. S. Krogh; L. T.H. Jacobsson

doi:10.1080/03009742.2018.1444199

Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016: a collaboration between five biological registries

B. Glintborg^*, U. Lindström, K. Aaltonen, E. K. Kristianslund, B. Gudbjornsson, K. Chatzidionysiou, J. Askling, D. Nordström, M. L. Hetland, D. Di Giuseppe, L. Dreyer, L. E. Kristensen, T. S. Jørgensen, K. Eklund, G. Grondal, S. Ernestam, J. Joensuu, M. R.K. Törmänen, H. Skydsgaard, J. HagforsT. K. Kvien, E. Lie, K. Fagerli, A. J. Geirsson, H. Jonsson, S. A. Provan, N. S. Krogh, L. T.H. Jacobsson

^*Corresponding author for this work

9 Citations (Scopus)

Abstract

Objectives: Large-scale observational cohorts may be used to study the effectiveness and rare side effects of biological disease-modifying anti-rheumatic drugs (bDMARDs) in ankylosing spondylitis (AS), but may be hampered by differences in baseline characteristics and disease activity across countries. We aimed to explore the research infrastructure in the five Nordic countries regarding bDMARD treatment in AS. Method: This observational cohort study was based on data from biological registries in Denmark (DANBIO), Sweden (SRQ/ARTIS), Finland (ROB-FIN), Norway (NOR-DMARD), and Iceland (ICEBIO). Data were collected for the years 2010–2016. Registry coverage, registry inventory (patient characteristics, disease activity measures), and national guidelines for bDMARD prescription in AS were described per country. Incident (first line) and prevalent bDMARD use per capita, country, and year were calculated. In AS patients who started first line bDMARDs during 2010–2016 (n = 4392), baseline characteristics and disease activity measures were retrieved. Results: Registry coverage of bDMARD-treated patients ranged from 60% to 95%. All registries included extensive prospectively collected data at patient level. Guidelines regarding choice of first line drug and prescription patterns varied across countries. During the period 2010–2016 prevalent bDMARD use increased (p < 0.001), whereas incident use tended to decrease (p for trend < 0.004), with large national variations (e.g. 2016 incidence: Iceland 10.7/100 000, Finland 1.7/100 000). Baseline characteristics were similar regarding C-reactive protein, but differed for other variables, including the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (range 3.5–6.3) and Ankylosing Spondylitis Disease Activity Score (ASDAS) (2.7–3.8) (both p < 0.0001). Conclusion: Collaboration across the five Nordic biological registries regarding bDMARD use in AS is feasible but national differences in coverage, prescription patterns, and patient characteristics must be taken into account depending on the scientific question.

Original language	English
Journal	Scandinavian Journal of Rheumatology
Volume	47
Issue number	6
Pages (from-to)	465-474
Number of pages	10
ISSN	0300-9742
DOIs	https://doi.org/10.1080/03009742.2018.1444199
Publication status	Published - 2018

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10.1080/03009742.2018.1444199

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Glintborg, B., Lindström, U., Aaltonen, K., Kristianslund, E. K., Gudbjornsson, B., Chatzidionysiou, K., Askling, J., Nordström, D., Hetland, M. L., Di Giuseppe, D., Dreyer, L., Kristensen, L. E., Jørgensen, T. S., Eklund, K., Grondal, G., Ernestam, S., Joensuu, J., Törmänen, M. R. K., Skydsgaard, H., ... Jacobsson, L. T. H. (2018). Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016: a collaboration between five biological registries. Scandinavian Journal of Rheumatology, 47(6), 465-474. https://doi.org/10.1080/03009742.2018.1444199

Glintborg, B, Lindström, U, Aaltonen, K, Kristianslund, EK, Gudbjornsson, B, Chatzidionysiou, K, Askling, J, Nordström, D, Hetland, ML, Di Giuseppe, D, Dreyer, L, Kristensen, LE, Jørgensen, TS, Eklund, K, Grondal, G, Ernestam, S, Joensuu, J, Törmänen, MRK, Skydsgaard, H, Hagfors, J, Kvien, TK, Lie, E, Fagerli, K, Geirsson, AJ, Jonsson, H, Provan, SA, Krogh, NS & Jacobsson, LTH 2018, 'Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016: a collaboration between five biological registries', Scandinavian Journal of Rheumatology, vol. 47, no. 6, pp. 465-474. https://doi.org/10.1080/03009742.2018.1444199

@article{265d80fe36b743028382072f1ae1b32a,

title = "Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016: a collaboration between five biological registries",

abstract = "Objectives: Large-scale observational cohorts may be used to study the effectiveness and rare side effects of biological disease-modifying anti-rheumatic drugs (bDMARDs) in ankylosing spondylitis (AS), but may be hampered by differences in baseline characteristics and disease activity across countries. We aimed to explore the research infrastructure in the five Nordic countries regarding bDMARD treatment in AS. Method: This observational cohort study was based on data from biological registries in Denmark (DANBIO), Sweden (SRQ/ARTIS), Finland (ROB-FIN), Norway (NOR-DMARD), and Iceland (ICEBIO). Data were collected for the years 2010–2016. Registry coverage, registry inventory (patient characteristics, disease activity measures), and national guidelines for bDMARD prescription in AS were described per country. Incident (first line) and prevalent bDMARD use per capita, country, and year were calculated. In AS patients who started first line bDMARDs during 2010–2016 (n = 4392), baseline characteristics and disease activity measures were retrieved. Results: Registry coverage of bDMARD-treated patients ranged from 60% to 95%. All registries included extensive prospectively collected data at patient level. Guidelines regarding choice of first line drug and prescription patterns varied across countries. During the period 2010–2016 prevalent bDMARD use increased (p < 0.001), whereas incident use tended to decrease (p for trend < 0.004), with large national variations (e.g. 2016 incidence: Iceland 10.7/100 000, Finland 1.7/100 000). Baseline characteristics were similar regarding C-reactive protein, but differed for other variables, including the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (range 3.5–6.3) and Ankylosing Spondylitis Disease Activity Score (ASDAS) (2.7–3.8) (both p < 0.0001). Conclusion: Collaboration across the five Nordic biological registries regarding bDMARD use in AS is feasible but national differences in coverage, prescription patterns, and patient characteristics must be taken into account depending on the scientific question.",

author = "B. Glintborg and U. Lindstr{\"o}m and K. Aaltonen and Kristianslund, {E. K.} and B. Gudbjornsson and K. Chatzidionysiou and J. Askling and D. Nordstr{\"o}m and Hetland, {M. L.} and {Di Giuseppe}, D. and L. Dreyer and Kristensen, {L. E.} and J{\o}rgensen, {T. S.} and K. Eklund and G. Grondal and S. Ernestam and J. Joensuu and T{\"o}rm{\"a}nen, {M. R.K.} and H. Skydsgaard and J. Hagfors and Kvien, {T. K.} and E. Lie and K. Fagerli and Geirsson, {A. J.} and H. Jonsson and Provan, {S. A.} and Krogh, {N. S.} and Jacobsson, {L. T.H.}",

year = "2018",

doi = "10.1080/03009742.2018.1444199",

language = "English",

volume = "47",

pages = "465--474",

journal = "Scandinavian Journal of Rheumatology",

issn = "0300-9742",

publisher = "Taylor & Francis",

number = "6",

}

TY - JOUR

T1 - Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016

T2 - a collaboration between five biological registries

AU - Glintborg, B.

AU - Lindström, U.

AU - Aaltonen, K.

AU - Kristianslund, E. K.

AU - Gudbjornsson, B.

AU - Chatzidionysiou, K.

AU - Askling, J.

AU - Nordström, D.

AU - Hetland, M. L.

AU - Di Giuseppe, D.

AU - Dreyer, L.

AU - Kristensen, L. E.

AU - Jørgensen, T. S.

AU - Eklund, K.

AU - Grondal, G.

AU - Ernestam, S.

AU - Joensuu, J.

AU - Törmänen, M. R.K.

AU - Skydsgaard, H.

AU - Hagfors, J.

AU - Kvien, T. K.

AU - Lie, E.

AU - Fagerli, K.

AU - Geirsson, A. J.

AU - Jonsson, H.

AU - Provan, S. A.

AU - Krogh, N. S.

AU - Jacobsson, L. T.H.

PY - 2018

Y1 - 2018

N2 - Objectives: Large-scale observational cohorts may be used to study the effectiveness and rare side effects of biological disease-modifying anti-rheumatic drugs (bDMARDs) in ankylosing spondylitis (AS), but may be hampered by differences in baseline characteristics and disease activity across countries. We aimed to explore the research infrastructure in the five Nordic countries regarding bDMARD treatment in AS. Method: This observational cohort study was based on data from biological registries in Denmark (DANBIO), Sweden (SRQ/ARTIS), Finland (ROB-FIN), Norway (NOR-DMARD), and Iceland (ICEBIO). Data were collected for the years 2010–2016. Registry coverage, registry inventory (patient characteristics, disease activity measures), and national guidelines for bDMARD prescription in AS were described per country. Incident (first line) and prevalent bDMARD use per capita, country, and year were calculated. In AS patients who started first line bDMARDs during 2010–2016 (n = 4392), baseline characteristics and disease activity measures were retrieved. Results: Registry coverage of bDMARD-treated patients ranged from 60% to 95%. All registries included extensive prospectively collected data at patient level. Guidelines regarding choice of first line drug and prescription patterns varied across countries. During the period 2010–2016 prevalent bDMARD use increased (p < 0.001), whereas incident use tended to decrease (p for trend < 0.004), with large national variations (e.g. 2016 incidence: Iceland 10.7/100 000, Finland 1.7/100 000). Baseline characteristics were similar regarding C-reactive protein, but differed for other variables, including the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (range 3.5–6.3) and Ankylosing Spondylitis Disease Activity Score (ASDAS) (2.7–3.8) (both p < 0.0001). Conclusion: Collaboration across the five Nordic biological registries regarding bDMARD use in AS is feasible but national differences in coverage, prescription patterns, and patient characteristics must be taken into account depending on the scientific question.

AB - Objectives: Large-scale observational cohorts may be used to study the effectiveness and rare side effects of biological disease-modifying anti-rheumatic drugs (bDMARDs) in ankylosing spondylitis (AS), but may be hampered by differences in baseline characteristics and disease activity across countries. We aimed to explore the research infrastructure in the five Nordic countries regarding bDMARD treatment in AS. Method: This observational cohort study was based on data from biological registries in Denmark (DANBIO), Sweden (SRQ/ARTIS), Finland (ROB-FIN), Norway (NOR-DMARD), and Iceland (ICEBIO). Data were collected for the years 2010–2016. Registry coverage, registry inventory (patient characteristics, disease activity measures), and national guidelines for bDMARD prescription in AS were described per country. Incident (first line) and prevalent bDMARD use per capita, country, and year were calculated. In AS patients who started first line bDMARDs during 2010–2016 (n = 4392), baseline characteristics and disease activity measures were retrieved. Results: Registry coverage of bDMARD-treated patients ranged from 60% to 95%. All registries included extensive prospectively collected data at patient level. Guidelines regarding choice of first line drug and prescription patterns varied across countries. During the period 2010–2016 prevalent bDMARD use increased (p < 0.001), whereas incident use tended to decrease (p for trend < 0.004), with large national variations (e.g. 2016 incidence: Iceland 10.7/100 000, Finland 1.7/100 000). Baseline characteristics were similar regarding C-reactive protein, but differed for other variables, including the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) (range 3.5–6.3) and Ankylosing Spondylitis Disease Activity Score (ASDAS) (2.7–3.8) (both p < 0.0001). Conclusion: Collaboration across the five Nordic biological registries regarding bDMARD use in AS is feasible but national differences in coverage, prescription patterns, and patient characteristics must be taken into account depending on the scientific question.

U2 - 10.1080/03009742.2018.1444199

DO - 10.1080/03009742.2018.1444199

M3 - Journal article

C2 - 30070923

AN - SCOPUS:85052229849

SN - 0300-9742

VL - 47

SP - 465

EP - 474

JO - Scandinavian Journal of Rheumatology

JF - Scandinavian Journal of Rheumatology

IS - 6

ER -

Biological treatment in ankylosing spondylitis in the Nordic countries during 2010–2016: a collaboration between five biological registries

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