Biological activity and LC-MS/MS profiling of extracts from the Australian medicinal plant Acacia ligulata (Fabaceae)

Diana Jæger Knudsen, Bradley S. Simpson, Chi P. Ndi, Anna Jäger, Christoph Crocoll, Birger Lindberg Møller, Philip Weinstein, Susan J. Semple

4 Citations (Scopus)

Abstract

Acacia ligulata A.Cunn. ex Benth. (Fabaceae: Mimosoideae) is a native Australian plant used traditionally by Australian Aboriginal groups. This study was undertaken to investigate the bioactivity of A. ligulata extracts and to evaluate their chemical composition. Potential antibacterial, cytotoxic and enzyme inhibitory effects relevant to traditional medicinal and food uses of the species were examined and LC-MS/MS was performed to investigate the chemical composition. Antibacterial activity was observed for bark and leaf extracts with an MIC for the bark extract of 62.5 μg/mL against Streptococcus pyogenes. Pod extracts showed cytotoxic effects against cancer cells, with the highest activity against melanoma SK-MEL28 cells with IC50 values between 40.8 and 80.6 μg/mL. Further, the leaf and pod extracts also inhibited α-amylase EC-3.2.1.1 and α-glucosidase EC-3.2.1.20 with IC50 values between 9.7-34.8 and 12.6-64.3 μg/mL, respectively. The LC-MS/MS profiling indicated that several different saponins were present in the active extracts.

Original languageEnglish
JournalNatural Product Research
Volume32
Issue number5
Pages (from-to)576-581
Number of pages6
ISSN1478-6419
DOIs
Publication statusPublished - 4 Mar 2018

Keywords

  • Journal Article

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