Biologic therapy in inflammatory bowel disease

TY - JOUR

T1 - Biologic therapy in inflammatory bowel disease

AU - Theede, Klaus

AU - Dahlerup, Jens Frederik

AU - Fallingborg, Jan

AU - Hvas, Christian Lodberg

AU - Kjeldsen, Jens

AU - Munck, Lars Kristian

AU - Nordgaard-Lassen, Inge

AU - Danish Society of Gastroenterology and Hepatology

PY - 2013/6

Y1 - 2013/6

N2 - In luminal Crohn's disease with moderate to severe inflammatory activity, infliximab and adalimumab can be used in the case of treatment failure with conventional therapies, such as systemic steroids and immunosuppressive therapy or if this treatment is not tolerated. Further treatment strategy depends on the primary response to induction therapy Effect of maintenance therapy should be evaluated clinically and paraclinically at least every 26-52 weeks, and maybe supplemented by endoscopy or MRI scan Decision of treatment discontinuation is based on disease manifestation, treatment response and paraclinical parameters In fistulising Crohn's disease, treatment with infliximab or adalimumab can be initiated in simple fistula with rectal inflammation or complex fistula when the initial treatment has insufficient effect. Further treatment strategy depends on the primary response to induction therapy Maintenance therapy is often necessary in complex fistulas Treatment efficacy and possible discontinuation of treatment is evaluated at least every 26-52 weeks - if possibly with diagnostic imaging In acute severe ulcerative colitis, treatment with infliximab can be used in patients with partial response after 3-5 days of treatment with a high-dose systemic steroid and when surgical treatment is not preferred or required. Further treatment strategy depends on the response to the first drug administration and colectomy should always be considered as an option Effect of subsequent initiated maintenance therapy should be evaluated at least every 26-52 weeks on the basis of symptoms, clinical markers, paraclinical parameters and possibly by endoscopy In chronic active ulcerative colitis, infliximab and adalimumab can be used in the case of treatment with immunosuppressive therapy fails and if surgery is not preferred. Further treatment strategy depends on the response to induction therapy Treatment efficacy is assessed by symptoms, clinical markers, paraclinical parameters and possibly by endoscopy Effect of maintenance therapy should be evaluated at least every 26-52 weeks During treatment with biologic drugs focus should be on possible complications, such as infections, infusion or injection reactions and dermatological side effects. An overview of levels of evidence and recommendations is presented I table 4.

AB - In luminal Crohn's disease with moderate to severe inflammatory activity, infliximab and adalimumab can be used in the case of treatment failure with conventional therapies, such as systemic steroids and immunosuppressive therapy or if this treatment is not tolerated. Further treatment strategy depends on the primary response to induction therapy Effect of maintenance therapy should be evaluated clinically and paraclinically at least every 26-52 weeks, and maybe supplemented by endoscopy or MRI scan Decision of treatment discontinuation is based on disease manifestation, treatment response and paraclinical parameters In fistulising Crohn's disease, treatment with infliximab or adalimumab can be initiated in simple fistula with rectal inflammation or complex fistula when the initial treatment has insufficient effect. Further treatment strategy depends on the primary response to induction therapy Maintenance therapy is often necessary in complex fistulas Treatment efficacy and possible discontinuation of treatment is evaluated at least every 26-52 weeks - if possibly with diagnostic imaging In acute severe ulcerative colitis, treatment with infliximab can be used in patients with partial response after 3-5 days of treatment with a high-dose systemic steroid and when surgical treatment is not preferred or required. Further treatment strategy depends on the response to the first drug administration and colectomy should always be considered as an option Effect of subsequent initiated maintenance therapy should be evaluated at least every 26-52 weeks on the basis of symptoms, clinical markers, paraclinical parameters and possibly by endoscopy In chronic active ulcerative colitis, infliximab and adalimumab can be used in the case of treatment with immunosuppressive therapy fails and if surgery is not preferred. Further treatment strategy depends on the response to induction therapy Treatment efficacy is assessed by symptoms, clinical markers, paraclinical parameters and possibly by endoscopy Effect of maintenance therapy should be evaluated at least every 26-52 weeks During treatment with biologic drugs focus should be on possible complications, such as infections, infusion or injection reactions and dermatological side effects. An overview of levels of evidence and recommendations is presented I table 4.

KW - Anti-Inflammatory Agents, Non-Steroidal

KW - Antibodies, Monoclonal

KW - Antibodies, Monoclonal, Humanized

KW - Biological Therapy

KW - Humans

KW - Inflammatory Bowel Diseases

KW - Severity of Illness Index

M3 - Journal article

C2 - 23743116

SN - 0041-5782

VL - 60

SP - B4652

JO - Ugeskrift for Laeger

JF - Ugeskrift for Laeger

IS - 6

ER -