Bioavailability of four oral Coenzyme Q formulations in healthy volunteers

M. Weis; S.A. Mortensen; M.R. Rassing; Jørn Sonnergaard; G. Poulsen; S.N. Rasmussen

Bioavailability of four oral Coenzyme Q formulations in healthy volunteers

M. Weis, S.A. Mortensen, M.R. Rassing, Jørn Sonnergaard, G. Poulsen, S.N. Rasmussen

84 Citations (Scopus)

Abstract

The bioavailability of four different Coenzyme Q (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatine capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatine capsules containing: 100 mg of CoQ with 400 mg of soy bean oil (Bioquinon); 100 mg of CoQ with 20 mg of polysorbate 80, 100 mg of lecithin and 280 mg of soy bean oil; and 100 mg of CoQ with 20 mg of polysorbate 80 and 380 mg of soy bean oil, respectively. The result suggests that the soya bean oil suspension of CoQ (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o.administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile.

Original language	English
Journal	Molecular Aspects of Medicine
Volume	15
Issue number	SUPPL. 1
ISSN	0098-2997
Publication status	Published - 1 Jan 1994

Cite this

@article{287b9773f8f74029ad5e6ce0091827ed,

title = "Bioavailability of four oral Coenzyme Q formulations in healthy volunteers",

abstract = "The bioavailability of four different Coenzyme Q (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatine capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatine capsules containing: 100 mg of CoQ with 400 mg of soy bean oil (Bioquinon); 100 mg of CoQ with 20 mg of polysorbate 80, 100 mg of lecithin and 280 mg of soy bean oil; and 100 mg of CoQ with 20 mg of polysorbate 80 and 380 mg of soy bean oil, respectively. The result suggests that the soya bean oil suspension of CoQ (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o.administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile.",

author = "M. Weis and S.A. Mortensen and M.R. Rassing and J{\o}rn Sonnergaard and G. Poulsen and S.N. Rasmussen",

year = "1994",

month = jan,

day = "1",

language = "English",

volume = "15",

journal = "Molecular Aspects of Medicine",

issn = "0098-2997",

publisher = "Pergamon Press",

number = "SUPPL. 1",

}

TY - JOUR

T1 - Bioavailability of four oral Coenzyme Q formulations in healthy volunteers

AU - Weis, M.

AU - Mortensen, S.A.

AU - Rassing, M.R.

AU - Sonnergaard, Jørn

AU - Poulsen, G.

AU - Rasmussen, S.N.

PY - 1994/1/1

Y1 - 1994/1/1

N2 - The bioavailability of four different Coenzyme Q (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatine capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatine capsules containing: 100 mg of CoQ with 400 mg of soy bean oil (Bioquinon); 100 mg of CoQ with 20 mg of polysorbate 80, 100 mg of lecithin and 280 mg of soy bean oil; and 100 mg of CoQ with 20 mg of polysorbate 80 and 380 mg of soy bean oil, respectively. The result suggests that the soya bean oil suspension of CoQ (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o.administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile.

AB - The bioavailability of four different Coenzyme Q (CoQ) formulations was compared in ten healthy volunteers in a four-way randomised cross-over trial. The included formulations were: A hard gelatine capsule containing 100 mg of CoQ and 400 mg of Emcompress. Three soft gelatine capsules containing: 100 mg of CoQ with 400 mg of soy bean oil (Bioquinon); 100 mg of CoQ with 20 mg of polysorbate 80, 100 mg of lecithin and 280 mg of soy bean oil; and 100 mg of CoQ with 20 mg of polysorbate 80 and 380 mg of soy bean oil, respectively. The result suggests that the soya bean oil suspension of CoQ (Bioquinon has the highest bioavailability. A difference in basic AUC and AUC after p.o.administration of CoQ was observed with respect to sex. A characteristic two peak-pattern was observed at the concentration-time profile.

UR - http://www.scopus.com/inward/record.url?scp=0028641240&partnerID=8YFLogxK

M3 - Journal article

AN - SCOPUS:0028641240

SN - 0098-2997

VL - 15

JO - Molecular Aspects of Medicine

JF - Molecular Aspects of Medicine

IS - SUPPL. 1

ER -

Bioavailability of four oral Coenzyme Q formulations in healthy volunteers

Abstract

Other files and links

Fingerprint

Cite this