Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration

TY - JOUR

T1 - Bifidobacteria or fiber protects against diet-induced microbiota-mediated colonic mucus deterioration

AU - Schroeder, Bjoern O

AU - Birchenough, George M H

AU - Ståhlman, Marcus

AU - Arike, Liisa

AU - Johansson, Malin E V

AU - Hansson, Gunnar C

AU - Bäckhed, Fredrik

N1 - Copyright © 2017 Elsevier Inc. All rights reserved.

PY - 2018/1/10

Y1 - 2018/1/10

N2 - Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis. The inner colonic mucus layer separates gut bacteria from their host. Schroeder et al. now find that gut bacteria can mediate functional defects of the mucus layer of mice fed a Western style diet. The defects can be prevented by application of a probiotic bifidobacteria or the prebiotic fiber inulin.

AB - Diet strongly affects gut microbiota composition, and gut bacteria can influence the colonic mucus layer, a physical barrier that separates trillions of gut bacteria from the host. However, the interplay between a Western style diet (WSD), gut microbiota composition, and the intestinal mucus layer is less clear. Here we show that mice fed a WSD have an altered colonic microbiota composition that causes increased penetrability and a reduced growth rate of the inner mucus layer. Both barrier defects can be prevented by transplanting microbiota from chow-fed mice. In addition, we found that administration of Bifidobacterium longum was sufficient to restore mucus growth, whereas administration of the fiber inulin prevented increased mucus penetrability in WSD-fed mice. We hypothesize that the presence of distinct bacteria is crucial for proper mucus function. If confirmed in humans, these findings may help to better understand diseases with an affected mucus layer, such as ulcerative colitis. The inner colonic mucus layer separates gut bacteria from their host. Schroeder et al. now find that gut bacteria can mediate functional defects of the mucus layer of mice fed a Western style diet. The defects can be prevented by application of a probiotic bifidobacteria or the prebiotic fiber inulin.

KW - Journal Article

U2 - 10.1016/j.chom.2017.11.004

DO - 10.1016/j.chom.2017.11.004

M3 - Journal article

C2 - 29276171

SN - 1931-3128

VL - 23

SP - 27-40 + e1-e7

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 1

ER -