Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes

Morten Bækgaard Thomsen; Paul G A Volders; Jet D M Beekman; Jørgen Matz; Marc A Vos

doi:10.1016/j.jacc.2006.05.048

Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes

Morten Bækgaard Thomsen, Paul G A Volders, Jet D M Beekman, Jørgen Matz, Marc A Vos

Physiology of circulation, kidney and lung

101 Citations (Scopus)

Abstract

We investigated whether increasing or decreasing beat-to-beat variability of repolarization (BVR) would change drug-induced proarrhythmic outcome accordingly.

Original language	English
Journal	Journal of the American College of Cardiology
Volume	48
Issue number	6
Pages (from-to)	1268-76
Number of pages	9
DOIs	https://doi.org/10.1016/j.jacc.2006.05.048
Publication status	Published - 19 Sept 2006

Keywords

Adenosine Triphosphate
Animals
Anti-Arrhythmia Agents
Arrhythmias, Cardiac
Cardiac Pacing, Artificial
Cromakalim
Disease Susceptibility
Dogs
Dose-Response Relationship, Drug
Heart Rate
Imidazoles
Indoles
Osmolar Concentration
Potassium
Potassium Channel Blockers
Potassium Channels
Potassium Chloride
Recurrence
Torsades de Pointes
Ventricular Function

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10.1016/j.jacc.2006.05.048

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Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes. / Thomsen, Morten Bækgaard; Volders, Paul G A; Beekman, Jet D M et al.

In: Journal of the American College of Cardiology, Vol. 48, No. 6, 19.09.2006, p. 1268-76.

Research output: Contribution to journal › Journal article › Research › peer-review

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title = "Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes",

abstract = "We investigated whether increasing or decreasing beat-to-beat variability of repolarization (BVR) would change drug-induced proarrhythmic outcome accordingly.",

keywords = "Adenosine Triphosphate, Animals, Anti-Arrhythmia Agents, Arrhythmias, Cardiac, Cardiac Pacing, Artificial, Cromakalim, Disease Susceptibility, Dogs, Dose-Response Relationship, Drug, Heart Rate, Imidazoles, Indoles, Osmolar Concentration, Potassium, Potassium Channel Blockers, Potassium Channels, Potassium Chloride, Recurrence, Torsades de Pointes, Ventricular Function",

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AU - Thomsen, Morten Bækgaard

AU - Volders, Paul G A

AU - Beekman, Jet D M

AU - Matz, Jørgen

AU - Vos, Marc A

PY - 2006/9/19

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KW - Arrhythmias, Cardiac

KW - Cardiac Pacing, Artificial

KW - Cromakalim

KW - Disease Susceptibility

KW - Dogs

KW - Dose-Response Relationship, Drug

KW - Heart Rate

KW - Imidazoles

KW - Indoles

KW - Osmolar Concentration

KW - Potassium

KW - Potassium Channel Blockers

KW - Potassium Channels

KW - Potassium Chloride

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DO - 10.1016/j.jacc.2006.05.048

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JO - Journal of the American College of Cardiology

JF - Journal of the American College of Cardiology

IS - 6

ER -

Beat-to-Beat variability of repolarization determines proarrhythmic outcome in dogs susceptible to drug-induced torsades de pointes

Abstract

Keywords

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