Basement membrane proteoglycans and development.

J R Couchman; D R Abrahamson; K J McCarthy

Basement membrane proteoglycans and development.

J R Couchman, D R Abrahamson, K J McCarthy

Nutritional Immunology

16 Citations (Scopus)

Abstract

Basement membranes contain distinct collagen, glycoprotein and proteoglycan species, and these exhibit considerable heterogeneity in isoform or type when different tissue types are compared. Additionally, many components are differentially expressed in organogenesis. We have considered the distributions in glomerulogenesis of two distinct basement membrane proteoglycans, a small heparan sulfate proteoglycan and a chondroitin sulfate proteoglycan (BM-CSPG). While the former was present in all kidney basement membranes through development, the latter was apparently regulated in distribution. BM-CSPG was only strongly expressed in the vasculature invading late comma stage glomeruli, and later in presumptive and mature Bowman's capsule. Over the first six to eight weeks, the capillary basement membranes contained BM-CSPG, but in gradually decreasing amounts until it became completely undetectable. The basement membrane of the adult rat glomerulus is unique in its lack of BM-CSPG. However, in diabetic rats, BM-CSPG is apparently re-expressed in the glomerular basement membrane, a potential marker for pathological changes in glomerular structure. While its function awaits elucidation, BM-CSPG may be essential for basement membrane integrity or stability and have important roles in kidney development.

Original language	English
Journal	Kidney International
Volume	43
Issue number	1
Pages (from-to)	79-84
Number of pages	5
ISSN	0085-2538
Publication status	Published - 1993

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title = "Basement membrane proteoglycans and development.",

abstract = "Basement membranes contain distinct collagen, glycoprotein and proteoglycan species, and these exhibit considerable heterogeneity in isoform or type when different tissue types are compared. Additionally, many components are differentially expressed in organogenesis. We have considered the distributions in glomerulogenesis of two distinct basement membrane proteoglycans, a small heparan sulfate proteoglycan and a chondroitin sulfate proteoglycan (BM-CSPG). While the former was present in all kidney basement membranes through development, the latter was apparently regulated in distribution. BM-CSPG was only strongly expressed in the vasculature invading late comma stage glomeruli, and later in presumptive and mature Bowman's capsule. Over the first six to eight weeks, the capillary basement membranes contained BM-CSPG, but in gradually decreasing amounts until it became completely undetectable. The basement membrane of the adult rat glomerulus is unique in its lack of BM-CSPG. However, in diabetic rats, BM-CSPG is apparently re-expressed in the glomerular basement membrane, a potential marker for pathological changes in glomerular structure. While its function awaits elucidation, BM-CSPG may be essential for basement membrane integrity or stability and have important roles in kidney development.",

author = "Couchman, {J R} and Abrahamson, {D R} and McCarthy, {K J}",

note = "Keywords: Animals; Basement Membrane; Diabetes Mellitus, Experimental; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Kidney; Microscopy, Immunoelectron; Proteochondroitin Sulfates; Proteoglycans; Rats; Tissue Distribution",

year = "1993",

language = "English",

volume = "43",

pages = "79--84",

journal = "Kidney International",

issn = "0085-2538",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Basement membrane proteoglycans and development.

AU - Couchman, J R

AU - Abrahamson, D R

AU - McCarthy, K J

N1 - Keywords: Animals; Basement Membrane; Diabetes Mellitus, Experimental; Heparan Sulfate Proteoglycans; Heparitin Sulfate; Kidney; Microscopy, Immunoelectron; Proteochondroitin Sulfates; Proteoglycans; Rats; Tissue Distribution

PY - 1993

Y1 - 1993

N2 - Basement membranes contain distinct collagen, glycoprotein and proteoglycan species, and these exhibit considerable heterogeneity in isoform or type when different tissue types are compared. Additionally, many components are differentially expressed in organogenesis. We have considered the distributions in glomerulogenesis of two distinct basement membrane proteoglycans, a small heparan sulfate proteoglycan and a chondroitin sulfate proteoglycan (BM-CSPG). While the former was present in all kidney basement membranes through development, the latter was apparently regulated in distribution. BM-CSPG was only strongly expressed in the vasculature invading late comma stage glomeruli, and later in presumptive and mature Bowman's capsule. Over the first six to eight weeks, the capillary basement membranes contained BM-CSPG, but in gradually decreasing amounts until it became completely undetectable. The basement membrane of the adult rat glomerulus is unique in its lack of BM-CSPG. However, in diabetic rats, BM-CSPG is apparently re-expressed in the glomerular basement membrane, a potential marker for pathological changes in glomerular structure. While its function awaits elucidation, BM-CSPG may be essential for basement membrane integrity or stability and have important roles in kidney development.

AB - Basement membranes contain distinct collagen, glycoprotein and proteoglycan species, and these exhibit considerable heterogeneity in isoform or type when different tissue types are compared. Additionally, many components are differentially expressed in organogenesis. We have considered the distributions in glomerulogenesis of two distinct basement membrane proteoglycans, a small heparan sulfate proteoglycan and a chondroitin sulfate proteoglycan (BM-CSPG). While the former was present in all kidney basement membranes through development, the latter was apparently regulated in distribution. BM-CSPG was only strongly expressed in the vasculature invading late comma stage glomeruli, and later in presumptive and mature Bowman's capsule. Over the first six to eight weeks, the capillary basement membranes contained BM-CSPG, but in gradually decreasing amounts until it became completely undetectable. The basement membrane of the adult rat glomerulus is unique in its lack of BM-CSPG. However, in diabetic rats, BM-CSPG is apparently re-expressed in the glomerular basement membrane, a potential marker for pathological changes in glomerular structure. While its function awaits elucidation, BM-CSPG may be essential for basement membrane integrity or stability and have important roles in kidney development.

M3 - Journal article

C2 - 8433574

SN - 0085-2538

VL - 43

SP - 79

EP - 84

JO - Kidney International

JF - Kidney International

IS - 1

ER -

Basement membrane proteoglycans and development.

Abstract

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