Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Abhijit Sen; Konstantinos K. Tsilidis; Naomi E. Allen; Sabina Rinaldi; Paul N. Appleby; Martin Almquist; Julie A. Schmidt; Christina C. Dahm; Kim Overvad; Anne Tjønneland; Agnetha Linn Rostgaard-Hansen; Françoise Clavel-Chapelon; Laura Baglietto; Marie Christine Boutron-Ruault; Tilman Kühn; Verena A. Katze; Heiner Boeing; Antonia Trichopoulou; Christos Tsironis; Pagona Lagiou; Domenico Palli; Valeria Pala; Salvatore Panico; Rosario Tumino; Paolo Vineis; H. B. Bueno-de-Mesquita; Petra H. Peeters; Anette Hjartåker; Eiliv Lund; Elisabete Weiderpass; J. Ramón Quirós; Antonio Agudo; María José Sánchez; Larraitz Arriola; Diana Gavrila; Aurelio Barricarte Gurrea; Ada Tosovic; Joakim Hennings; Maria Sandström; Isabelle Romieu; Pietro Ferrari; Raul Zamora-Ros; Kay Tee Khaw; Nicholas J. Wareham; Elio Riboli; Marc Gunter; Silvia Franceschi

doi:10.1038/bjc.2015.280

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Abhijit Sen, Konstantinos K. Tsilidis^*, Naomi E. Allen, Sabina Rinaldi, Paul N. Appleby, Martin Almquist, Julie A. Schmidt, Christina C. Dahm, Kim Overvad, Anne Tjønneland, Agnetha Linn Rostgaard-Hansen, Françoise Clavel-Chapelon, Laura Baglietto, Marie Christine Boutron-Ruault, Tilman Kühn, Verena A. Katze, Heiner Boeing, Antonia Trichopoulou, Christos Tsironis, Pagona LagiouDomenico Palli, Valeria Pala, Salvatore Panico, Rosario Tumino, Paolo Vineis, H. B. Bueno-de-Mesquita, Petra H. Peeters, Anette Hjartåker, Eiliv Lund, Elisabete Weiderpass, J. Ramón Quirós, Antonio Agudo, María José Sánchez, Larraitz Arriola, Diana Gavrila, Aurelio Barricarte Gurrea, Ada Tosovic, Joakim Hennings, Maria Sandström, Isabelle Romieu, Pietro Ferrari, Raul Zamora-Ros, Kay Tee Khaw, Nicholas J. Wareham, Elio Riboli, Marc Gunter, Silvia Franceschi

^*Corresponding author for this work

11 Citations (Scopus)

Abstract

Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered.

Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models.

Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes.

Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.

Original language	English
Journal	B J C
Volume	113
Issue number	5
Pages (from-to)	840-847
Number of pages	8
ISSN	0007-0920
DOIs	https://doi.org/10.1038/bjc.2015.280
Publication status	Published - 2015
Externally published	Yes

Keywords

Alcohol consumption
Lifetime exposure
Prospective study
Thyroid carcinoma

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1038/bjc.2015.280

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Sen, A., Tsilidis, K. K., Allen, N. E., Rinaldi, S., Appleby, P. N., Almquist, M., Schmidt, J. A., Dahm, C. C., Overvad, K., Tjønneland, A., Rostgaard-Hansen, A. L., Clavel-Chapelon, F., Baglietto, L., Boutron-Ruault, M. C., Kühn, T., Katze, V. A., Boeing, H., Trichopoulou, A., Tsironis, C., ... Franceschi, S. (2015). Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study. B J C, 113(5), 840-847. https://doi.org/10.1038/bjc.2015.280

Sen, A, Tsilidis, KK, Allen, NE, Rinaldi, S, Appleby, PN, Almquist, M, Schmidt, JA, Dahm, CC, Overvad, K, Tjønneland, A , Rostgaard-Hansen, AL, Clavel-Chapelon, F, Baglietto, L, Boutron-Ruault, MC, Kühn, T, Katze, VA, Boeing, H, Trichopoulou, A, Tsironis, C, Lagiou, P, Palli, D, Pala, V, Panico, S, Tumino, R, Vineis, P, Bueno-de-Mesquita, HB, Peeters, PH, Hjartåker, A, Lund, E, Weiderpass, E, Quirós, JR, Agudo, A, Sánchez, MJ, Arriola, L, Gavrila, D, Gurrea, AB, Tosovic, A, Hennings, J, Sandström, M, Romieu, I, Ferrari, P, Zamora-Ros, R, Khaw, KT, Wareham, NJ, Riboli, E, Gunter, M & Franceschi, S 2015, 'Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study', B J C, vol. 113, no. 5, pp. 840-847. https://doi.org/10.1038/bjc.2015.280

@article{9be5f94d916c411191b6bd6513d3742e,

title = "Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study",

abstract = "Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.",

keywords = "Alcohol consumption, Lifetime exposure, Prospective study, Thyroid carcinoma",

author = "Abhijit Sen and Tsilidis, {Konstantinos K.} and Allen, {Naomi E.} and Sabina Rinaldi and Appleby, {Paul N.} and Martin Almquist and Schmidt, {Julie A.} and Dahm, {Christina C.} and Kim Overvad and Anne Tj{\o}nneland and Rostgaard-Hansen, {Agnetha Linn} and Fran{\c c}oise Clavel-Chapelon and Laura Baglietto and Boutron-Ruault, {Marie Christine} and Tilman K{\"u}hn and Katze, {Verena A.} and Heiner Boeing and Antonia Trichopoulou and Christos Tsironis and Pagona Lagiou and Domenico Palli and Valeria Pala and Salvatore Panico and Rosario Tumino and Paolo Vineis and Bueno-de-Mesquita, {H. B.} and Peeters, {Petra H.} and Anette Hjart{\aa}ker and Eiliv Lund and Elisabete Weiderpass and Quir{\'o}s, {J. Ram{\'o}n} and Antonio Agudo and S{\'a}nchez, {Mar{\'i}a Jos{\'e}} and Larraitz Arriola and Diana Gavrila and Gurrea, {Aurelio Barricarte} and Ada Tosovic and Joakim Hennings and Maria Sandstr{\"o}m and Isabelle Romieu and Pietro Ferrari and Raul Zamora-Ros and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Elio Riboli and Marc Gunter and Silvia Franceschi",

year = "2015",

doi = "10.1038/bjc.2015.280",

language = "English",

volume = "113",

pages = "840--847",

journal = "The British journal of cancer. Supplement",

issn = "0007-0920",

publisher = "nature publishing group",

number = "5",

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TY - JOUR

T1 - Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

AU - Sen, Abhijit

AU - Tsilidis, Konstantinos K.

AU - Allen, Naomi E.

AU - Rinaldi, Sabina

AU - Appleby, Paul N.

AU - Almquist, Martin

AU - Schmidt, Julie A.

AU - Dahm, Christina C.

AU - Overvad, Kim

AU - Tjønneland, Anne

AU - Rostgaard-Hansen, Agnetha Linn

AU - Clavel-Chapelon, Françoise

AU - Baglietto, Laura

AU - Boutron-Ruault, Marie Christine

AU - Kühn, Tilman

AU - Katze, Verena A.

AU - Boeing, Heiner

AU - Trichopoulou, Antonia

AU - Tsironis, Christos

AU - Lagiou, Pagona

AU - Palli, Domenico

AU - Pala, Valeria

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Vineis, Paolo

AU - Bueno-de-Mesquita, H. B.

AU - Peeters, Petra H.

AU - Hjartåker, Anette

AU - Lund, Eiliv

AU - Weiderpass, Elisabete

AU - Quirós, J. Ramón

AU - Agudo, Antonio

AU - Sánchez, María José

AU - Arriola, Larraitz

AU - Gavrila, Diana

AU - Gurrea, Aurelio Barricarte

AU - Tosovic, Ada

AU - Hennings, Joakim

AU - Sandström, Maria

AU - Romieu, Isabelle

AU - Ferrari, Pietro

AU - Zamora-Ros, Raul

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Riboli, Elio

AU - Gunter, Marc

AU - Franceschi, Silvia

PY - 2015

Y1 - 2015

N2 - Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.

AB - Background: Results from several cohort and case-control studies suggest a protective association between current alcohol intake and risk of thyroid carcinoma, but the epidemiological evidence is not completely consistent and several questions remain unanswered. Methods: The association between alcohol consumption at recruitment and over the lifetime and risk of differentiated thyroid carcinoma was examined in the European Prospective Investigation into Cancer and Nutrition. Among 477 263 eligible participants (70% women), 556 (90% women) were diagnosed with differentiated thyroid carcinoma over a mean follow-up of 11 years. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using multivariable Cox proportional hazards models. Results: Compared with participants consuming 0.1-4.9 g of alcohol per day at recruitment, participants consuming 15 or more grams (approximately 1-1.5 drinks) had a 23% lower risk of differentiated thyroid carcinoma (HR=0.77; 95% CI=0.60-0.98). These findings did not differ greatly when analyses were conducted for lifetime alcohol consumption, although the risk estimates were attenuated and not statistically significant anymore. Similar results were observed by type of alcoholic beverage, by differentiated thyroid carcinoma histology or according to age, sex, smoking status, body mass index and diabetes. Conclusions: Our study provides some support to the hypothesis that moderate alcohol consumption may be associated with a lower risk of papillary and follicular thyroid carcinomas.

KW - Alcohol consumption

KW - Lifetime exposure

KW - Prospective study

KW - Thyroid carcinoma

U2 - 10.1038/bjc.2015.280

DO - 10.1038/bjc.2015.280

M3 - Journal article

C2 - 26313664

AN - SCOPUS:84940788094

SN - 0007-0920

VL - 113

SP - 840

EP - 847

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

IS - 5

ER -

Baseline and lifetime alcohol consumption and risk of differentiated thyroid carcinoma in the EPIC study

Abstract

Keywords

UN SDGs

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