Bacteremia and candidemia in hematological malignancies: clinical findings

D Hovgaard; P Skinhøj; Jette Marie Bangsborg; B Bruun; M Mørk Hansen; N I Nissen

Bacteremia and candidemia in hematological malignancies: clinical findings

D Hovgaard, P Skinhøj, Jette Marie Bangsborg, B Bruun, M Mørk Hansen, N I Nissen

13 Citations (Scopus)

Abstract

171 episodes of bacteremia and candidemia in 142 patients were recorded during the period 1981-1985 in patients with hematological malignancies. Overall mortality, within 1 week of onset of bacteremia, was 20%. Increased mortality was found in patients with poor disease-prognosis (39%), with granulocytopenia for more than 6 days (30%), and in those developing hypotension (49%). Compared to a similar previous study from 1970-1974, the incidence of bacteremia remained unchanged, but the mortality had decreased by 50%. This result could not be explained by changes in microbial spectrum, in patient groups, or in the initial antibiotic regimen used. An improved general condition of these patients due to better supportive treatment may be the single most important factor in improving the outcome of septicemia.

Original language	English
Journal	Scandinavian Journal of Infectious Diseases
Volume	20
Issue number	5
Pages (from-to)	495-501
Number of pages	7
ISSN	0036-5548
Publication status	Published - 1988

Keywords

Candidiasis
Cause of Death
Humans
Leukemia
Lymphoma, Non-Hodgkin
Opportunistic Infections
Retrospective Studies
Risk Factors
Sepsis

Cite this

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title = "Bacteremia and candidemia in hematological malignancies: clinical findings",

abstract = "171 episodes of bacteremia and candidemia in 142 patients were recorded during the period 1981-1985 in patients with hematological malignancies. Overall mortality, within 1 week of onset of bacteremia, was 20%. Increased mortality was found in patients with poor disease-prognosis (39%), with granulocytopenia for more than 6 days (30%), and in those developing hypotension (49%). Compared to a similar previous study from 1970-1974, the incidence of bacteremia remained unchanged, but the mortality had decreased by 50%. This result could not be explained by changes in microbial spectrum, in patient groups, or in the initial antibiotic regimen used. An improved general condition of these patients due to better supportive treatment may be the single most important factor in improving the outcome of septicemia.",

keywords = "Candidiasis, Cause of Death, Humans, Leukemia, Lymphoma, Non-Hodgkin, Opportunistic Infections, Retrospective Studies, Risk Factors, Sepsis",

author = "D Hovgaard and P Skinh{\o}j and Bangsborg, {Jette Marie} and B Bruun and {M{\o}rk Hansen}, M and Nissen, {N I}",

year = "1988",

language = "English",

volume = "20",

pages = "495--501",

journal = "Scandinavian Journal of Infectious Diseases",

issn = "0036-5548",

publisher = "Taylor & Francis",

number = "5",

}

TY - JOUR

T1 - Bacteremia and candidemia in hematological malignancies

T2 - clinical findings

AU - Hovgaard, D

AU - Skinhøj, P

AU - Bangsborg, Jette Marie

AU - Bruun, B

AU - Mørk Hansen, M

AU - Nissen, N I

PY - 1988

Y1 - 1988

N2 - 171 episodes of bacteremia and candidemia in 142 patients were recorded during the period 1981-1985 in patients with hematological malignancies. Overall mortality, within 1 week of onset of bacteremia, was 20%. Increased mortality was found in patients with poor disease-prognosis (39%), with granulocytopenia for more than 6 days (30%), and in those developing hypotension (49%). Compared to a similar previous study from 1970-1974, the incidence of bacteremia remained unchanged, but the mortality had decreased by 50%. This result could not be explained by changes in microbial spectrum, in patient groups, or in the initial antibiotic regimen used. An improved general condition of these patients due to better supportive treatment may be the single most important factor in improving the outcome of septicemia.

AB - 171 episodes of bacteremia and candidemia in 142 patients were recorded during the period 1981-1985 in patients with hematological malignancies. Overall mortality, within 1 week of onset of bacteremia, was 20%. Increased mortality was found in patients with poor disease-prognosis (39%), with granulocytopenia for more than 6 days (30%), and in those developing hypotension (49%). Compared to a similar previous study from 1970-1974, the incidence of bacteremia remained unchanged, but the mortality had decreased by 50%. This result could not be explained by changes in microbial spectrum, in patient groups, or in the initial antibiotic regimen used. An improved general condition of these patients due to better supportive treatment may be the single most important factor in improving the outcome of septicemia.

KW - Candidiasis

KW - Cause of Death

KW - Humans

KW - Leukemia

KW - Lymphoma, Non-Hodgkin

KW - Opportunistic Infections

KW - Retrospective Studies

KW - Risk Factors

KW - Sepsis

M3 - Journal article

C2 - 3222666

SN - 0036-5548

VL - 20

SP - 495

EP - 501

JO - Scandinavian Journal of Infectious Diseases

JF - Scandinavian Journal of Infectious Diseases

IS - 5

ER -

Bacteremia and candidemia in hematological malignancies: clinical findings

Abstract

Keywords

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