BacMet: antibacterial biocide and metal resistance genes database

Chandan Pal; Johan Bengtsson-Palme; Christopher Günther T Rensing; Erik Kristiansson; D.G. Joakim Larsson

doi:10.1093/nar/gkt1252

BacMet: antibacterial biocide and metal resistance genes database

Chandan Pal, Johan Bengtsson-Palme, Christopher Günther T Rensing, Erik Kristiansson, D.G. Joakim Larsson^*

^*Corresponding author for this work

Microbial Ecology and Biotechnology

224 Citations (Scopus)

Abstract

Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se) - a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype.

Original language	English
Journal	Nucleic Acids Research
Volume	42
Issue number	D1
Pages (from-to)	D737-D743
Number of pages	7
ISSN	0305-1048
DOIs	https://doi.org/10.1093/nar/gkt1252
Publication status	Published - 2014

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abstract = "Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se) - a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype.",

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T2 - antibacterial biocide and metal resistance genes database

AU - Pal, Chandan

AU - Bengtsson-Palme, Johan

AU - Rensing, Christopher Günther T

AU - Kristiansson, Erik

AU - Larsson, D.G. Joakim

PY - 2014

Y1 - 2014

N2 - Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se) - a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype.

AB - Antibiotic resistance has become a major human health concern due to widespread use, misuse and overuse of antibiotics. In addition to antibiotics, antibacterial biocides and metals can contribute to the development and maintenance of antibiotic resistance in bacterial communities through co-selection. Information on metal and biocide resistance genes, including their sequences and molecular functions, is, however, scattered. Here, we introduce BacMet (http://bacmet.biomedicine.gu.se) - a manually curated database of antibacterial biocide- and metal-resistance genes based on an in-depth review of the scientific literature. The BacMet database contains 470 experimentally verified resistance genes. In addition, the database also contains 25 477 potential resistance genes collected from public sequence repositories. All resistance genes in the BacMet database have been organized according to their molecular function and induced resistance phenotype.

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SP - D737-D743

JO - Nucleic Acids Research

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BacMet: antibacterial biocide and metal resistance genes database

Abstract

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