Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation:  A randomized clinical trial

T N Nissen; N M Birk; B A Blok; R J W Arts; A Andersen; J Kjærgaard; L M Thøstesen; T Hoffmann; D L Jeppesen; S D Nielsen; P-E Kofoed; L G Stensballe; P Aaby; M Ruhwald; M G Netea; C S Benn; O Pryds

doi:10.1007/s10096-017-3097-2

Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation: A randomized clinical trial

T N Nissen, N M Birk, B A Blok, R J W Arts, A Andersen, J Kjærgaard, L M Thøstesen, T Hoffmann, D L Jeppesen, S D Nielsen, P-E Kofoed, L G Stensballe, P Aaby, M Ruhwald, M G Netea, C S Benn, O Pryds

Department of Clinical Medicine

11 Citations (Scopus)

Abstract

Several studies have shown increased in vitro cytokine responses to non-related pathogens after Bacillus Calmette-Guérin (BCG) vaccination. A total of 158 infants (80 BCG administered within 7 days of birth; 78 controls) were bled 4 days post-randomization, and at age 3 and 13 months. Geometric mean concentrations of IL-1β, TNF-α, IL-6 (24 h stimulation) and IFN-γ, IL-10, IL-17, IL-22 (96 h stimulation) in response to in vitro stimulation with RPMI, LPS, PHA, Escherichia coli, Streptococcus pneumoniae, Candida albicans and BCG were compared among BCG vaccinated children and controls. BCG vaccination did not affect in vitro cytokine production, except IFN-γ and IL-22 response to BCG. Stratifying for 'age at randomization' we found a potentiating effect of BCG on cytokine production (TNF-α, IL-6, IL-10) in the 4 days post randomization stimulations, among children who were vaccinated at age 2-7 days versus age 0-1 days. BCG vaccination did not potentiate cytokine production to non-BCG antigens. At 4 days post randomization, BCG was associated with higher cytokine production in the later randomized children.

Original language	English
Journal	European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
Volume	37
Issue number	1
Pages (from-to)	29-41
Number of pages	13
ISSN	0934-9723
DOIs	https://doi.org/10.1007/s10096-017-3097-2
Publication status	Published - 1 Jan 2018

Keywords

Journal Article

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Nissen, T. N., Birk, N. M., Blok, B. A., Arts, R. J. W., Andersen, A., Kjærgaard, J., Thøstesen, L. M., Hoffmann, T., Jeppesen, D. L., Nielsen, S. D., Kofoed, P.-E., Stensballe, L. G., Aaby, P., Ruhwald, M., Netea, M. G., Benn, C. S., & Pryds, O. (2018). Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation: A randomized clinical trial. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 37(1), 29-41. https://doi.org/10.1007/s10096-017-3097-2

Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation: A randomized clinical trial. / Nissen, T N; Birk, N M; Blok, B A et al.
In: European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, Vol. 37, No. 1, 01.01.2018, p. 29-41.

Research output: Contribution to journal › Journal article › Research › peer-review

Nissen, TN, Birk, NM, Blok, BA, Arts, RJW, Andersen, A, Kjærgaard, J, Thøstesen, LM, Hoffmann, T, Jeppesen, DL, Nielsen, SD, Kofoed, P-E, Stensballe, LG, Aaby, P, Ruhwald, M, Netea, MG, Benn, CS & Pryds, O 2018, 'Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation: A randomized clinical trial', European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, vol. 37, no. 1, pp. 29-41. https://doi.org/10.1007/s10096-017-3097-2

Nissen TN, Birk NM, Blok BA, Arts RJW, Andersen A, Kjærgaard J et al. Bacillus Calmette-Guérin vaccination at birth and in vitro cytokine responses to non-specific stimulation: A randomized clinical trial. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology. 2018 Jan 1;37(1):29-41. doi: 10.1007/s10096-017-3097-2

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AU - Jeppesen, D L

AU - Nielsen, S D

AU - Kofoed, P-E

AU - Stensballe, L G

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