BacHBerry: BACterial hosts for production of bioactive phenolics from bERRY fruits

Alexey Dudnik; A. Filipa Almeida; Ricardo Andrade; Barbara Avila; Pilar Bañados; Diane Barbay; Jean-Étienne André Bassard; Mounir Benkoulouche; Michael Bott; Adelaide Braga; Dario Breitel; Rex Brennan; Laurent Bulteau; Celine Chanforan; Inês Costa; Rafael S. Costa; Mahdi Doostmohammadi; Nuno Faria; Chengyong Feng; Armando Fernandes; Patricia Ferreira; Roberto Ferro; Alexandre Foito; Sabine Freitag; Gonçalo Garcia; Paula Gaspar; Joana Godinho-Pereira; Björn Robert Hamberger; András Hartmann; Harald Heider; Carolina Jardim; Alice Julien-Laferriere; Nicolai Kallscheuer; Wolfgang Kerbe; Oscar P. Kuipers; Shanshan Li; Nicola Love; Alberto Marchetti-Spaccamela; Jan Marienhagen; Cathie Martin; Arnaud Mary; Vincent Mazurek; Camillo Meinhart; David Méndez Sevillano; Regina Menezes; Michael Naesby; Morten H.H. Nørholm; Finn T. Okkels; Steen Gustav Stahlhut; Michael Vogt

doi:10.1007/s11101-017-9532-2

BacHBerry: BACterial hosts for production of bioactive phenolics from bERRY fruits

Alexey Dudnik^*, A. Filipa Almeida, Ricardo Andrade, Barbara Avila, Pilar Bañados, Diane Barbay, Jean-Étienne André Bassard, Mounir Benkoulouche, Michael Bott, Adelaide Braga, Dario Breitel, Rex Brennan, Laurent Bulteau, Celine Chanforan, Inês Costa, Rafael S. Costa, Mahdi Doostmohammadi, Nuno Faria, Chengyong Feng, Armando FernandesPatricia Ferreira, Roberto Ferro, Alexandre Foito, Sabine Freitag, Gonçalo Garcia, Paula Gaspar, Joana Godinho-Pereira, Björn Robert Hamberger, András Hartmann, Harald Heider, Carolina Jardim, Alice Julien-Laferriere, Nicolai Kallscheuer, Wolfgang Kerbe, Oscar P. Kuipers, Shanshan Li, Nicola Love, Alberto Marchetti-Spaccamela, Jan Marienhagen, Cathie Martin, Arnaud Mary, Vincent Mazurek, Camillo Meinhart, David Méndez Sevillano, Regina Menezes, Michael Naesby, Morten H.H. Nørholm, Finn T. Okkels, Steen Gustav Stahlhut, Michael Vogt

^*Corresponding author for this work

Section for Plant Biochemistry

12 Citations (Scopus)

Abstract

BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

Original language	English
Journal	Phytochemistry Reviews
Volume	17
Issue number	2
Pages (from-to)	291-326
Number of pages	36
ISSN	1568-7767
DOIs	https://doi.org/10.1007/s11101-017-9532-2
Publication status	Published - 1 Apr 2018

Keywords

Berries
Bioprospecting
Microbial cell factories
Polyphenols
Sustainable production

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10.1007/s11101-017-9532-2

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Dudnik, A., Almeida, A. F., Andrade, R., Avila, B., Bañados, P., Barbay, D., Bassard, J-É. A., Benkoulouche, M., Bott, M., Braga, A., Breitel, D., Brennan, R., Bulteau, L., Chanforan, C., Costa, I., Costa, R. S., Doostmohammadi, M., Faria, N., Feng, C., ... Vogt, M. (2018). BacHBerry: BACterial hosts for production of bioactive phenolics from bERRY fruits. Phytochemistry Reviews, 17(2), 291-326. https://doi.org/10.1007/s11101-017-9532-2

Dudnik, A, Almeida, AF, Andrade, R, Avila, B, Bañados, P, Barbay, D, Bassard, J-ÉA, Benkoulouche, M, Bott, M, Braga, A, Breitel, D, Brennan, R, Bulteau, L, Chanforan, C, Costa, I, Costa, RS, Doostmohammadi, M, Faria, N, Feng, C, Fernandes, A, Ferreira, P, Ferro, R, Foito, A, Freitag, S, Garcia, G, Gaspar, P, Godinho-Pereira, J, Hamberger, BR, Hartmann, A, Heider, H, Jardim, C, Julien-Laferriere, A, Kallscheuer, N, Kerbe, W, Kuipers, OP, Li, S, Love, N, Marchetti-Spaccamela, A, Marienhagen, J, Martin, C, Mary, A, Mazurek, V, Meinhart, C, Sevillano, DM, Menezes, R, Naesby, M, Nørholm, MHH, Okkels, FT, Stahlhut, SG & Vogt, M 2018, 'BacHBerry: BACterial hosts for production of bioactive phenolics from bERRY fruits', Phytochemistry Reviews, vol. 17, no. 2, pp. 291-326. https://doi.org/10.1007/s11101-017-9532-2

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abstract = "BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.",

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AU - Avila, Barbara

AU - Bañados, Pilar

AU - Barbay, Diane

AU - Bassard, Jean-Étienne André

AU - Benkoulouche, Mounir

AU - Bott, Michael

AU - Braga, Adelaide

AU - Breitel, Dario

AU - Brennan, Rex

AU - Bulteau, Laurent

AU - Chanforan, Celine

AU - Costa, Inês

AU - Costa, Rafael S.

AU - Doostmohammadi, Mahdi

AU - Faria, Nuno

AU - Feng, Chengyong

AU - Fernandes, Armando

AU - Ferreira, Patricia

AU - Ferro, Roberto

AU - Foito, Alexandre

AU - Freitag, Sabine

AU - Garcia, Gonçalo

AU - Gaspar, Paula

AU - Godinho-Pereira, Joana

AU - Hamberger, Björn Robert

AU - Hartmann, András

AU - Heider, Harald

AU - Jardim, Carolina

AU - Julien-Laferriere, Alice

AU - Kallscheuer, Nicolai

AU - Kerbe, Wolfgang

AU - Kuipers, Oscar P.

AU - Li, Shanshan

AU - Love, Nicola

AU - Marchetti-Spaccamela, Alberto

AU - Marienhagen, Jan

AU - Martin, Cathie

AU - Mary, Arnaud

AU - Mazurek, Vincent

AU - Meinhart, Camillo

AU - Sevillano, David Méndez

AU - Menezes, Regina

AU - Naesby, Michael

AU - Nørholm, Morten H.H.

AU - Okkels, Finn T.

AU - Stahlhut, Steen Gustav

AU - Vogt, Michael

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AB - BACterial Hosts for production of Bioactive phenolics from bERRY fruits (BacHBerry) was a 3-year project funded by the Seventh Framework Programme (FP7) of the European Union that ran between November 2013 and October 2016. The overall aim of the project was to establish a sustainable and economically-feasible strategy for the production of novel high-value phenolic compounds isolated from berry fruits using bacterial platforms. The project aimed at covering all stages of the discovery and pre-commercialization process, including berry collection, screening and characterization of their bioactive components, identification and functional characterization of the corresponding biosynthetic pathways, and construction of Gram-positive bacterial cell factories producing phenolic compounds. Further activities included optimization of polyphenol extraction methods from bacterial cultures, scale-up of production by fermentation up to pilot scale, as well as societal and economic analyses of the processes. This review article summarizes some of the key findings obtained throughout the duration of the project.

KW - Berries

KW - Bioprospecting

KW - Microbial cell factories

KW - Polyphenols

KW - Sustainable production

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DO - 10.1007/s11101-017-9532-2

M3 - Journal article

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JO - Phytochemistry Reviews

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BacHBerry: BACterial hosts for production of bioactive phenolics from bERRY fruits

Abstract

Keywords

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