B-type natriuretic peptide secretion following scuba diving

Claudio Passino; Enrico Franzino; Alberto Giannoni; Concetta Prontera; Jens Peter Goetze; Michele Emdin; Aldo Clerico

doi:10.2217/bmm.11.14

B-type natriuretic peptide secretion following scuba diving

Claudio Passino, Enrico Franzino, Alberto Giannoni, Concetta Prontera, Jens Peter Goetze, Michele Emdin, Aldo Clerico

8 Citations (Scopus)

Abstract

Aim: To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor. Materials & methods: We studied 12 healthy scuba divers (mean age ± standard deviation: 44 ± 7 years; range: 34-55 years; BMI: 24.8 ± 2.8 kg/m²), who performed a 15-m depth dive in salt water, with a bottom time of 30 min. Blood samples for BNPs (pro-B-type natriuretic peptide [pro-BNP], BNP and aminoterminal pro-BNP) and catecholamines were measured in plasma before immersion, and after the dive. A continuous electrocardiographic recording was obtained during the entire protocol. Results: BNP, aminoterminal pro-BNP and pro-BNP plasma concentrations slightly, but significantly, increased after the scuba dive (18 ± 15 to 21 ± 11 ng/l, p = 0.020; 32 ± 19 to 38 ± 21 ng/l, p = 0.008; and 7.8 ± 1.6 to 10.3 ± 3.6 ng/l, p = 0.028, respectively) in parallel with norepinephrine concentration (743 ± 323 to 1163 ± 656 ng/l, p = 0.014), with no variations in total plasma proteins, hematocrit or osmolality. A persistent sinus tachycardia was observed during all phases of the dive. Conclusions: A 15-m depth scuba dive induces an acute slight release of the different peptide fragments from the BNP precursor, likely through the stimulation of a constitutive secretory pathway promoted by adrenergic activation and cardiac chamber dilation.

Original language	English
Journal	Biomarkers in Medicine
Volume	5
Issue number	2
Pages (from-to)	205-9
Number of pages	5
ISSN	1752-0363
DOIs	https://doi.org/10.2217/bmm.11.14
Publication status	Published - Apr 2011

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@article{31d990e4b6d44e2294d8ccb099d890de,

title = "B-type natriuretic peptide secretion following scuba diving",

abstract = "Aim: To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor. Materials & methods: We studied 12 healthy scuba divers (mean age ± standard deviation: 44 ± 7 years; range: 34-55 years; BMI: 24.8 ± 2.8 kg/m2), who performed a 15-m depth dive in salt water, with a bottom time of 30 min. Blood samples for BNPs (pro-B-type natriuretic peptide [pro-BNP], BNP and aminoterminal pro-BNP) and catecholamines were measured in plasma before immersion, and after the dive. A continuous electrocardiographic recording was obtained during the entire protocol. Results: BNP, aminoterminal pro-BNP and pro-BNP plasma concentrations slightly, but significantly, increased after the scuba dive (18 ± 15 to 21 ± 11 ng/l, p = 0.020; 32 ± 19 to 38 ± 21 ng/l, p = 0.008; and 7.8 ± 1.6 to 10.3 ± 3.6 ng/l, p = 0.028, respectively) in parallel with norepinephrine concentration (743 ± 323 to 1163 ± 656 ng/l, p = 0.014), with no variations in total plasma proteins, hematocrit or osmolality. A persistent sinus tachycardia was observed during all phases of the dive. Conclusions: A 15-m depth scuba dive induces an acute slight release of the different peptide fragments from the BNP precursor, likely through the stimulation of a constitutive secretory pathway promoted by adrenergic activation and cardiac chamber dilation.",

author = "Claudio Passino and Enrico Franzino and Alberto Giannoni and Concetta Prontera and Goetze, {Jens Peter} and Michele Emdin and Aldo Clerico",

year = "2011",

month = apr,

doi = "10.2217/bmm.11.14",

language = "English",

volume = "5",

pages = "205--9",

journal = "Biomarkers in Medicine",

issn = "1752-0363",

publisher = "Future Medicine Ltd.",

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TY - JOUR

T1 - B-type natriuretic peptide secretion following scuba diving

AU - Passino, Claudio

AU - Franzino, Enrico

AU - Giannoni, Alberto

AU - Prontera, Concetta

AU - Goetze, Jens Peter

AU - Emdin, Michele

AU - Clerico, Aldo

PY - 2011/4

Y1 - 2011/4

N2 - Aim: To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor. Materials & methods: We studied 12 healthy scuba divers (mean age ± standard deviation: 44 ± 7 years; range: 34-55 years; BMI: 24.8 ± 2.8 kg/m2), who performed a 15-m depth dive in salt water, with a bottom time of 30 min. Blood samples for BNPs (pro-B-type natriuretic peptide [pro-BNP], BNP and aminoterminal pro-BNP) and catecholamines were measured in plasma before immersion, and after the dive. A continuous electrocardiographic recording was obtained during the entire protocol. Results: BNP, aminoterminal pro-BNP and pro-BNP plasma concentrations slightly, but significantly, increased after the scuba dive (18 ± 15 to 21 ± 11 ng/l, p = 0.020; 32 ± 19 to 38 ± 21 ng/l, p = 0.008; and 7.8 ± 1.6 to 10.3 ± 3.6 ng/l, p = 0.028, respectively) in parallel with norepinephrine concentration (743 ± 323 to 1163 ± 656 ng/l, p = 0.014), with no variations in total plasma proteins, hematocrit or osmolality. A persistent sinus tachycardia was observed during all phases of the dive. Conclusions: A 15-m depth scuba dive induces an acute slight release of the different peptide fragments from the BNP precursor, likely through the stimulation of a constitutive secretory pathway promoted by adrenergic activation and cardiac chamber dilation.

AB - Aim: To examine the neurohormonal effects of a scuba dive, focusing on the acute changes in the plasma concentrations of the different peptide fragments from the B-type natriuretic peptide (BNP) precursor. Materials & methods: We studied 12 healthy scuba divers (mean age ± standard deviation: 44 ± 7 years; range: 34-55 years; BMI: 24.8 ± 2.8 kg/m2), who performed a 15-m depth dive in salt water, with a bottom time of 30 min. Blood samples for BNPs (pro-B-type natriuretic peptide [pro-BNP], BNP and aminoterminal pro-BNP) and catecholamines were measured in plasma before immersion, and after the dive. A continuous electrocardiographic recording was obtained during the entire protocol. Results: BNP, aminoterminal pro-BNP and pro-BNP plasma concentrations slightly, but significantly, increased after the scuba dive (18 ± 15 to 21 ± 11 ng/l, p = 0.020; 32 ± 19 to 38 ± 21 ng/l, p = 0.008; and 7.8 ± 1.6 to 10.3 ± 3.6 ng/l, p = 0.028, respectively) in parallel with norepinephrine concentration (743 ± 323 to 1163 ± 656 ng/l, p = 0.014), with no variations in total plasma proteins, hematocrit or osmolality. A persistent sinus tachycardia was observed during all phases of the dive. Conclusions: A 15-m depth scuba dive induces an acute slight release of the different peptide fragments from the BNP precursor, likely through the stimulation of a constitutive secretory pathway promoted by adrenergic activation and cardiac chamber dilation.

U2 - 10.2217/bmm.11.14

DO - 10.2217/bmm.11.14

M3 - Journal article

C2 - 21473725

SN - 1752-0363

VL - 5

SP - 205

EP - 209

JO - Biomarkers in Medicine

JF - Biomarkers in Medicine

IS - 2

ER -

B-type natriuretic peptide secretion following scuba diving

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