Azide- and alkyne-derivatised α-amino acids

Karl Henrik Johansson; D.S. Pedersen

doi:10.1002/ejoc.201200496

Azide- and alkyne-derivatised α-amino acids

Karl Henrik Johansson, D.S. Pedersen

46 Citations (Scopus)

Abstract

With the emergence of the copper-catalysed Huisgen cycloaddition the use of azide- and alkyne-derivatised α-amino acids has found widespread use within most chemistry disciplines. Despite a growing interest in these building blocks researchers are struggling to identify the best way for their synthesis. In this review we have compiled available methods for synthesising optically active azide- and alkyne-derivatised α-amino acids that can be prepared from readily available α-amino acids. We highlight a number of commonly overlooked problems associated with existing methods and direct attention to unexplored possibilities. Azide- and alkyne-derivatised α-amino acids are finding widespread use within most chemistry disciplines. However, it is far from clear what the best way for the synthesis of these useful building blocks is. Herein we show the available methods for synthesis of optically active azide- and alkyne-derivatised α-amino acids, highlight pitfalls and direct attention to unexplored possibilities.

Original language	English
Journal	European Journal of Organic Chemistry
Volume	2012
Issue number	23
Pages (from-to)	4267-4281
Number of pages	15
ISSN	1434-193X
DOIs	https://doi.org/10.1002/ejoc.201200496
Publication status	Published - 1 Aug 2012

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abstract = "With the emergence of the copper-catalysed Huisgen cycloaddition the use of azide- and alkyne-derivatised α-amino acids has found widespread use within most chemistry disciplines. Despite a growing interest in these building blocks researchers are struggling to identify the best way for their synthesis. In this review we have compiled available methods for synthesising optically active azide- and alkyne-derivatised α-amino acids that can be prepared from readily available α-amino acids. We highlight a number of commonly overlooked problems associated with existing methods and direct attention to unexplored possibilities. Azide- and alkyne-derivatised α-amino acids are finding widespread use within most chemistry disciplines. However, it is far from clear what the best way for the synthesis of these useful building blocks is. Herein we show the available methods for synthesis of optically active azide- and alkyne-derivatised α-amino acids, highlight pitfalls and direct attention to unexplored possibilities.",

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AU - Pedersen, D.S.

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Azide- and alkyne-derivatised α-amino acids

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