Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy

Pernille Nørgaard; Dave Wright; Susan Ball; Paul Newell; Ida Sejersdahl Kirkegaard; Olav Bjørn Petersen; Niels Uldbjerg; Niels Tørring; Finn Stener Jørgensen; Lennart Friis-Hansen; Charlotte Ekelund; Ann Tabor; Steen Sørensen

doi:10.1515/cclm-2012-0805

Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy

Pernille Nørgaard, Dave Wright, Susan Ball, Paul Newell, Ida Sejersdahl Kirkegaard, Olav Bjørn Petersen, Niels Uldbjerg, Niels Tørring, Finn Stener Jørgensen, Lennart Friis-Hansen, Charlotte Ekelund, Ann Tabor, Steen Sørensen

Department of Clinical Medicine

2 Citations (Scopus)

Abstract

Background: Theoretically, repeated sampling of free β- human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation. Methods: A prospective study was conducted including 3891 unaffected singleton pregnancies. Two measurements of hCGβ and PAPP-A were obtained during the first trimester in each pregnancy. Correlations between the four parameters, hCGβ first, hCGβ second, PAPP-A first and PAPP-A second, were estimated and presented in terms of Pearson's r coefficients. Furthermore, the correlation between paired samples as a function of time between samples was investigated. Results: The study demonstrated high correlation between first and second samples of hCGβ and PAPP-A with a correlation coefficient of 0.80 and 0.79, respectively. By contrast, the correlations between hCGβ and PAPP-A were low. In addition, the study demonstrated that the correlation between paired samples of hCGβ and PAPP-A decreases with earlier gestational age at the first sample and with increasing time between samples. Conclusions: We have developed a parameter set in terms of correlations between biochemical markers, which can be incorporated into a T21 screening algorithm based on repeated measures within the first trimester.

Original language	English
Journal	Clinical Chemistry and Laboratory Medicine
Volume	51
Issue number	9
Pages (from-to)	1781-1788
Number of pages	8
ISSN	1434-6621
DOIs	https://doi.org/10.1515/cclm-2012-0805
Publication status	Published - Sept 2013

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Nørgaard, P., Wright, D., Ball, S., Newell, P., Kirkegaard, I. S., Petersen, O. B., Uldbjerg, N., Tørring, N., Jørgensen, F. S., Friis-Hansen, L., Ekelund, C., Tabor, A., & Sørensen, S. (2013). Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy. Clinical Chemistry and Laboratory Medicine, 51(9), 1781-1788. https://doi.org/10.1515/cclm-2012-0805

Nørgaard, P, Wright, D, Ball, S, Newell, P, Kirkegaard, IS, Petersen, OB, Uldbjerg, N, Tørring, N, Jørgensen, FS , Friis-Hansen, L , Ekelund, C , Tabor, A & Sørensen, S 2013, 'Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy', Clinical Chemistry and Laboratory Medicine, vol. 51, no. 9, pp. 1781-1788. https://doi.org/10.1515/cclm-2012-0805

@article{6d7a85103de2469d8b3224a297fd1e0e,

title = "Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy",

abstract = "Background: Theoretically, repeated sampling of free β- human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation. Methods: A prospective study was conducted including 3891 unaffected singleton pregnancies. Two measurements of hCGβ and PAPP-A were obtained during the first trimester in each pregnancy. Correlations between the four parameters, hCGβ first, hCGβ second, PAPP-A first and PAPP-A second, were estimated and presented in terms of Pearson's r coefficients. Furthermore, the correlation between paired samples as a function of time between samples was investigated. Results: The study demonstrated high correlation between first and second samples of hCGβ and PAPP-A with a correlation coefficient of 0.80 and 0.79, respectively. By contrast, the correlations between hCGβ and PAPP-A were low. In addition, the study demonstrated that the correlation between paired samples of hCGβ and PAPP-A decreases with earlier gestational age at the first sample and with increasing time between samples. Conclusions: We have developed a parameter set in terms of correlations between biochemical markers, which can be incorporated into a T21 screening algorithm based on repeated measures within the first trimester.",

author = "Pernille N{\o}rgaard and Dave Wright and Susan Ball and Paul Newell and Kirkegaard, {Ida Sejersdahl} and Petersen, {Olav Bj{\o}rn} and Niels Uldbjerg and Niels T{\o}rring and J{\o}rgensen, {Finn Stener} and Lennart Friis-Hansen and Charlotte Ekelund and Ann Tabor and Steen S{\o}rensen",

year = "2013",

month = sep,

doi = "10.1515/cclm-2012-0805",

language = "English",

volume = "51",

pages = "1781--1788",

journal = "Clinical Chemistry and Laboratory Medicine",

issn = "1434-6621",

publisher = "Walterde Gruyter GmbH",

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}

TY - JOUR

T1 - Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy

AU - Nørgaard, Pernille

AU - Wright, Dave

AU - Ball, Susan

AU - Newell, Paul

AU - Kirkegaard, Ida Sejersdahl

AU - Petersen, Olav Bjørn

AU - Uldbjerg, Niels

AU - Tørring, Niels

AU - Jørgensen, Finn Stener

AU - Friis-Hansen, Lennart

AU - Ekelund, Charlotte

AU - Tabor, Ann

AU - Sørensen, Steen

PY - 2013/9

Y1 - 2013/9

N2 - Background: Theoretically, repeated sampling of free β- human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation. Methods: A prospective study was conducted including 3891 unaffected singleton pregnancies. Two measurements of hCGβ and PAPP-A were obtained during the first trimester in each pregnancy. Correlations between the four parameters, hCGβ first, hCGβ second, PAPP-A first and PAPP-A second, were estimated and presented in terms of Pearson's r coefficients. Furthermore, the correlation between paired samples as a function of time between samples was investigated. Results: The study demonstrated high correlation between first and second samples of hCGβ and PAPP-A with a correlation coefficient of 0.80 and 0.79, respectively. By contrast, the correlations between hCGβ and PAPP-A were low. In addition, the study demonstrated that the correlation between paired samples of hCGβ and PAPP-A decreases with earlier gestational age at the first sample and with increasing time between samples. Conclusions: We have developed a parameter set in terms of correlations between biochemical markers, which can be incorporated into a T21 screening algorithm based on repeated measures within the first trimester.

AB - Background: Theoretically, repeated sampling of free β- human chorionic gonadotropin (hCGβ) and pregnancy associated plasma protein-A (PAPP-A) in the first trimester of pregnancy might improve performance of risk assessment of trisomy 21 (T21). To assess the performance of a screening test involving repeated measures of biochemical markers, correlations between markers must be estimated. The aims of this study were to calculate the autocorrelation and cross-correlation between hCGβ and PAPP-A in the first trimester of pregnancy and to investigate the possible impact of gestational age at the first sample and time between sampling on the correlation. Methods: A prospective study was conducted including 3891 unaffected singleton pregnancies. Two measurements of hCGβ and PAPP-A were obtained during the first trimester in each pregnancy. Correlations between the four parameters, hCGβ first, hCGβ second, PAPP-A first and PAPP-A second, were estimated and presented in terms of Pearson's r coefficients. Furthermore, the correlation between paired samples as a function of time between samples was investigated. Results: The study demonstrated high correlation between first and second samples of hCGβ and PAPP-A with a correlation coefficient of 0.80 and 0.79, respectively. By contrast, the correlations between hCGβ and PAPP-A were low. In addition, the study demonstrated that the correlation between paired samples of hCGβ and PAPP-A decreases with earlier gestational age at the first sample and with increasing time between samples. Conclusions: We have developed a parameter set in terms of correlations between biochemical markers, which can be incorporated into a T21 screening algorithm based on repeated measures within the first trimester.

U2 - 10.1515/cclm-2012-0805

DO - 10.1515/cclm-2012-0805

M3 - Journal article

C2 - 23612665

SN - 1434-6621

VL - 51

SP - 1781

EP - 1788

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

IS - 9

ER -

Autocorrelation and cross-correlation between hCGβ and PAPP-A in repeated sampling during first trimester of pregnancy

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