Abstract
Antibodies against interleukin-1 alpha (aAb-IL-1 alpha) have previously been demonstrated in sera of healthy adults and in patients with inflammatory diseases. In the present investigation the occurrence of aAb-IL-1 alpha was examined by second antibody precipitation technique in sera from umbilical cords (n = 11), children (n = 45), and adults (n = 20), as well as in 51 patients with juvenile chronic arthritis (JCA) of pauciarticular (n = 34), polyarticular (n = 8), or systemic onset type (n = 9). RESULTS. The frequency of positive sera was significantly lower in children than in cord blood and adults as were the levels of aAb-IL-1 alpha (p <0.0001). In the non-neonatal group of individuals the levels of aAb-IL-1 alpha correlated positively with age (r = 0.394, p = 0.0015). The frequency of sera positive for aAb-IL-1 alpha was higher in the JCA patients, as were the levels (p <0.005), and correlated positively with disease activity as evaluated by joint score and visual analogue score.
| Original language | English |
|---|---|
| Journal | Scandinavian Journal of Rheumatology |
| Volume | 25 |
| Issue number | 3 |
| Pages (from-to) | 164-7 |
| Number of pages | 4 |
| ISSN | 0300-9742 |
| Publication status | Published - 1 Jan 1996 |
Keywords
- Adult
- Age Factors
- Arthritis, Juvenile Rheumatoid
- Autoantibodies
- Child
- Female
- Fetal Blood
- Humans
- Interleukin-1
- Male