Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis

Nils Landegren; Mina Pourmousa Lindberg; Jakob Skov; Åsa Hallgren; Daniel Eriksson; Trine Lisberg Toft-Bertelsen; Nanna MacAulay; Eva Hagforsen; Anne Räisänen-Sokolowski; Heikki Saha; Thomas Nilsson; Gunnel Nordmark; Sophie Ohlsson; Jan Gustafsson; Eystein S Husebye; Erik Larsson; Mark S Anderson; Jaakko Perheentupa; Fredrik Rorsman; Robert A Fenton; Olle Kämpe

doi:10.1681/asn.2015101126

Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis

Nils Landegren, Mina Pourmousa Lindberg, Jakob Skov, Åsa Hallgren, Daniel Eriksson, Trine Lisberg Toft-Bertelsen, Nanna MacAulay, Eva Hagforsen, Anne Räisänen-Sokolowski, Heikki Saha, Thomas Nilsson, Gunnel Nordmark, Sophie Ohlsson, Jan Gustafsson, Eystein S Husebye, Erik Larsson, Mark S Anderson, Jaakko Perheentupa, Fredrik Rorsman, Robert A FentonOlle Kämpe

ICMM Section 8

9 Citations (Scopus)

Abstract

Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.

Original language	English
Journal	Journal of the American Society of Nephrology:JASN
Volume	27
Issue number	10
Pages (from-to)	3220-3228
ISSN	1046-6673
DOIs	https://doi.org/10.1681/asn.2015101126
Publication status	Published - Oct 2016

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Landegren, N., Pourmousa Lindberg, M., Skov, J., Hallgren, Å., Eriksson, D., Lisberg Toft-Bertelsen, T., MacAulay, N., Hagforsen, E., Räisänen-Sokolowski, A., Saha, H., Nilsson, T., Nordmark, G., Ohlsson, S., Gustafsson, J., Husebye, E. S., Larsson, E., Anderson, M. S., Perheentupa, J., Rorsman, F., ... Kämpe, O. (2016). Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis. Journal of the American Society of Nephrology:JASN, 27(10), 3220-3228. https://doi.org/10.1681/asn.2015101126

Landegren, N, Pourmousa Lindberg, M, Skov, J, Hallgren, Å, Eriksson, D, Lisberg Toft-Bertelsen, T , MacAulay, N, Hagforsen, E, Räisänen-Sokolowski, A, Saha, H, Nilsson, T, Nordmark, G, Ohlsson, S, Gustafsson, J, Husebye, ES, Larsson, E, Anderson, MS, Perheentupa, J, Rorsman, F, Fenton, RA & Kämpe, O 2016, 'Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis', Journal of the American Society of Nephrology:JASN, vol. 27, no. 10, pp. 3220-3228. https://doi.org/10.1681/asn.2015101126

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title = "Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis",

abstract = "Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.",

author = "Nils Landegren and {Pourmousa Lindberg}, Mina and Jakob Skov and {\AA}sa Hallgren and Daniel Eriksson and {Lisberg Toft-Bertelsen}, Trine and Nanna MacAulay and Eva Hagforsen and Anne R{\"a}is{\"a}nen-Sokolowski and Heikki Saha and Thomas Nilsson and Gunnel Nordmark and Sophie Ohlsson and Jan Gustafsson and Husebye, {Eystein S} and Erik Larsson and Anderson, {Mark S} and Jaakko Perheentupa and Fredrik Rorsman and Fenton, {Robert A} and Olle K{\"a}mpe",

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doi = "10.1681/asn.2015101126",

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T1 - Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis

AU - Landegren, Nils

AU - Pourmousa Lindberg, Mina

AU - Skov, Jakob

AU - Hallgren, Åsa

AU - Eriksson, Daniel

AU - Lisberg Toft-Bertelsen, Trine

AU - MacAulay, Nanna

AU - Hagforsen, Eva

AU - Räisänen-Sokolowski, Anne

AU - Saha, Heikki

AU - Nilsson, Thomas

AU - Nordmark, Gunnel

AU - Ohlsson, Sophie

AU - Gustafsson, Jan

AU - Husebye, Eystein S

AU - Larsson, Erik

AU - Anderson, Mark S

AU - Perheentupa, Jaakko

AU - Rorsman, Fredrik

AU - Fenton, Robert A

AU - Kämpe, Olle

PY - 2016/10

Y1 - 2016/10

N2 - Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.

AB - Tubulointerstitial nephritis is a common cause of kidney failure and may have diverse etiologies. This form of nephritis is sometimes associated with autoimmune disease, but the role of autoimmune mechanisms in disease development is not well understood. Here, we present the cases of three patients with autoimmune polyendocrine syndrome type 1 who developed tubulointerstitial nephritis and ESRD in association with autoantibodies against kidney collecting duct cells. One of the patients developed autoantibodies targeting the collecting duct-specific water channel aquaporin 2, whereas autoantibodies of the two other patients reacted against the HOXB7 or NFAT5 transcription factors, which regulate the aquaporin 2 promoter. Our findings suggest that tubulointerstitial nephritis developed in these patients as a result of an autoimmune insult on the kidney collecting duct cells.

U2 - 10.1681/asn.2015101126

DO - 10.1681/asn.2015101126

M3 - Journal article

C2 - 26984885

SN - 1046-6673

VL - 27

SP - 3220

EP - 3228

JO - Journal of the American Society of Nephrology : JASN

JF - Journal of the American Society of Nephrology : JASN

IS - 10

ER -

Autoantibodies Targeting a Collecting Duct-Specific Water Channel in Tubulointerstitial Nephritis

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