AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITROBY PYRIMETHAMINE

IB CHRISTIAN BYGBJERG

doi:10.1111/j.1699-0463.1981.tb02673.x

AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITROBY PYRIMETHAMINE

IB CHRISTIAN BYGBJERG^*

^*Corresponding author for this work

Global Health Section

6 Citations (Scopus)

Abstract

Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned. 1981 Acta Pathologica, Microbiologica et Immunologica Scandinavica

Original language	English
Journal	Acta Pathologica Microbiologica Scandinavica Section C Immunology
Volume	89 C
Issue number	1-6
Pages (from-to)	111-114
Number of pages	4
ISSN	0304-1328
DOIs	https://doi.org/10.1111/j.1699-0463.1981.tb02673.x
Publication status	Published - 1 Jan 1981

Keywords

Antimalarials
immunopotention
lymphocyte transformation
pyrimethamine
trimethoprim

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10.1111/j.1699-0463.1981.tb02673.x

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title = "AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITROBY PYRIMETHAMINE",

abstract = "Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned. 1981 Acta Pathologica, Microbiologica et Immunologica Scandinavica",

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N2 - Thymidine incorporation by human blood mononuclear cells, unstimulated and stimulated with phytohaemagglutinin (PHA), pokeweed mitogen (PWM) and purified protein derivate of tuberculin (PPD) was studied with and without addition of pyrimethamine. Responses were increased significantly by pyrimethamine in the PWM and PPD stimulated cultures, in the PPD cultures even by concentrations of pyrimethamine, which can be achieved with therapeutic doses of this drug. The closely related compound trimethoprim did not alter PHA‐, PWM‐ and PPD‐responses significantly. The possibility of using pyrimethamine ‐ a widely used prophylactic antimalarial ‐ as an immunopotentiator is mentioned. 1981 Acta Pathologica, Microbiologica et Immunologica Scandinavica

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AUGMENTATION OF HUMAN LYMPHOCYTE PROLIFERATIVE RESPONSES IN VITROBY PYRIMETHAMINE

Abstract

Keywords

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