Atrial natriuretic peptide and renal adaptation to contralateral nephrectomy in healthy man.

A L Kamper; E B Pedersen; S Strandgaard; N H Holstein-Rathlou; P P Leyssac; P Skaarup; L Hemmingsen; J Holm; O Munck

Atrial natriuretic peptide and renal adaptation to contralateral nephrectomy in healthy man.

A L Kamper, E B Pedersen, S Strandgaard, N H Holstein-Rathlou, P P Leyssac, P Skaarup, L Hemmingsen, J Holm, O Munck

Department of Biomedical Sciences

5 Citations (Scopus)

Abstract

Atrial natriuretic peptide (ANP), angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP) in plasma were determined in 12 healthy renal transplant donors before and 5, 12, 26, 54 days after uninephrectomy (Nx) in order to study the possible role of these hormones in functional adaptation to acute reduction in renal mass. Glomerular and tubular function was studied by measurements of the clearances of 51Cr-EDTA, lithium, sodium, potassium, and albumin. ANP was 7.4 +/- 3.1 pmol l-1 (mean +/- SD) before Nx and 8.7 +/- 6.1 pmol l-1 at 5 days after Nx and remained at this level through the observation period. Aldo showed a non-significant transient fall at 5 days after Nx. AII and AVP remained normal after Nx. At 5 days after Nx glomerular filtration rate (GFR) of the remaining kidney had risen from 45 +/- 7 ml min-1 before Nx to 57 +/- 8 ml min-1 (p less than 0.01), lithium clearance had risen from 13 +/- 2 ml min-1 before Nx to 20 +/- 7 ml min-1 (p less than 0.01), and sodium and water balance was normal. To conclude, plasma ANP, AII, Aldo and AVP do not appear to be responsible for the hyperfiltration and depression of fractional proximal sodium and water reabsorption observed in recently uninephrectomized man with normal sodium and water balance.

Original language	English
Journal	Scandinavian Journal of Clinical & Laboratory Investigation
Volume	51
Issue number	1
Pages (from-to)	99-103
Number of pages	4
ISSN	0036-5513
Publication status	Published - 1991

Cite this

@article{dccfa450abec11ddb5e9000ea68e967b,

title = "Atrial natriuretic peptide and renal adaptation to contralateral nephrectomy in healthy man.",

abstract = "Atrial natriuretic peptide (ANP), angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP) in plasma were determined in 12 healthy renal transplant donors before and 5, 12, 26, 54 days after uninephrectomy (Nx) in order to study the possible role of these hormones in functional adaptation to acute reduction in renal mass. Glomerular and tubular function was studied by measurements of the clearances of 51Cr-EDTA, lithium, sodium, potassium, and albumin. ANP was 7.4 +/- 3.1 pmol l-1 (mean +/- SD) before Nx and 8.7 +/- 6.1 pmol l-1 at 5 days after Nx and remained at this level through the observation period. Aldo showed a non-significant transient fall at 5 days after Nx. AII and AVP remained normal after Nx. At 5 days after Nx glomerular filtration rate (GFR) of the remaining kidney had risen from 45 +/- 7 ml min-1 before Nx to 57 +/- 8 ml min-1 (p less than 0.01), lithium clearance had risen from 13 +/- 2 ml min-1 before Nx to 20 +/- 7 ml min-1 (p less than 0.01), and sodium and water balance was normal. To conclude, plasma ANP, AII, Aldo and AVP do not appear to be responsible for the hyperfiltration and depression of fractional proximal sodium and water reabsorption observed in recently uninephrectomized man with normal sodium and water balance.",

author = "Kamper, {A L} and Pedersen, {E B} and S Strandgaard and Holstein-Rathlou, {N H} and Leyssac, {P P} and P Skaarup and L Hemmingsen and J Holm and O Munck",

note = "Keywords: Absorption; Adaptation, Physiological; Adult; Aldosterone; Angiotensin II; Arginine Vasopressin; Atrial Natriuretic Factor; Body Water; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Nephrectomy; Sodium; Tissue Donors; Water-Electrolyte Balance",

year = "1991",

language = "English",

volume = "51",

pages = "99--103",

journal = "Scandinavian Journal of Clinical & Laboratory Investigation",

issn = "0036-5513",

publisher = "Taylor & Francis",

number = "1",

}

TY - JOUR

T1 - Atrial natriuretic peptide and renal adaptation to contralateral nephrectomy in healthy man.

AU - Kamper, A L

AU - Pedersen, E B

AU - Strandgaard, S

AU - Holstein-Rathlou, N H

AU - Leyssac, P P

AU - Skaarup, P

AU - Hemmingsen, L

AU - Holm, J

AU - Munck, O

N1 - Keywords: Absorption; Adaptation, Physiological; Adult; Aldosterone; Angiotensin II; Arginine Vasopressin; Atrial Natriuretic Factor; Body Water; Female; Glomerular Filtration Rate; Humans; Kidney; Kidney Glomerulus; Kidney Tubules; Male; Middle Aged; Nephrectomy; Sodium; Tissue Donors; Water-Electrolyte Balance

PY - 1991

Y1 - 1991

N2 - Atrial natriuretic peptide (ANP), angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP) in plasma were determined in 12 healthy renal transplant donors before and 5, 12, 26, 54 days after uninephrectomy (Nx) in order to study the possible role of these hormones in functional adaptation to acute reduction in renal mass. Glomerular and tubular function was studied by measurements of the clearances of 51Cr-EDTA, lithium, sodium, potassium, and albumin. ANP was 7.4 +/- 3.1 pmol l-1 (mean +/- SD) before Nx and 8.7 +/- 6.1 pmol l-1 at 5 days after Nx and remained at this level through the observation period. Aldo showed a non-significant transient fall at 5 days after Nx. AII and AVP remained normal after Nx. At 5 days after Nx glomerular filtration rate (GFR) of the remaining kidney had risen from 45 +/- 7 ml min-1 before Nx to 57 +/- 8 ml min-1 (p less than 0.01), lithium clearance had risen from 13 +/- 2 ml min-1 before Nx to 20 +/- 7 ml min-1 (p less than 0.01), and sodium and water balance was normal. To conclude, plasma ANP, AII, Aldo and AVP do not appear to be responsible for the hyperfiltration and depression of fractional proximal sodium and water reabsorption observed in recently uninephrectomized man with normal sodium and water balance.

AB - Atrial natriuretic peptide (ANP), angiotensin II (AII), aldosterone (Aldo) and arginine vasopressin (AVP) in plasma were determined in 12 healthy renal transplant donors before and 5, 12, 26, 54 days after uninephrectomy (Nx) in order to study the possible role of these hormones in functional adaptation to acute reduction in renal mass. Glomerular and tubular function was studied by measurements of the clearances of 51Cr-EDTA, lithium, sodium, potassium, and albumin. ANP was 7.4 +/- 3.1 pmol l-1 (mean +/- SD) before Nx and 8.7 +/- 6.1 pmol l-1 at 5 days after Nx and remained at this level through the observation period. Aldo showed a non-significant transient fall at 5 days after Nx. AII and AVP remained normal after Nx. At 5 days after Nx glomerular filtration rate (GFR) of the remaining kidney had risen from 45 +/- 7 ml min-1 before Nx to 57 +/- 8 ml min-1 (p less than 0.01), lithium clearance had risen from 13 +/- 2 ml min-1 before Nx to 20 +/- 7 ml min-1 (p less than 0.01), and sodium and water balance was normal. To conclude, plasma ANP, AII, Aldo and AVP do not appear to be responsible for the hyperfiltration and depression of fractional proximal sodium and water reabsorption observed in recently uninephrectomized man with normal sodium and water balance.

M3 - Journal article

C2 - 1826969

SN - 0036-5513

VL - 51

SP - 99

EP - 103

JO - Scandinavian Journal of Clinical & Laboratory Investigation

JF - Scandinavian Journal of Clinical & Laboratory Investigation

IS - 1

ER -

Atrial natriuretic peptide and renal adaptation to contralateral nephrectomy in healthy man.

Abstract

Fingerprint

Cite this