Atovaquone/proguanil resistance in Africa: a case report

Kim P David; Michael Alifrangis; Ali Salanti; Lasse S Vestergaard; Anita Rønn; I B Bygbjerg

Atovaquone/proguanil resistance in Africa: a case report

Kim P David, Michael Alifrangis, Ali Salanti, Lasse S Vestergaard, Anita Rønn, I B Bygbjerg

34 Citations (Scopus)

Abstract

The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.

Original language	English
Journal	Scandinavian Journal of Infectious Diseases
Volume	35
Issue number	11-12
Pages (from-to)	897-8
Number of pages	1
ISSN	0036-5548
Publication status	Published - 2003

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title = "Atovaquone/proguanil resistance in Africa: a case report",

abstract = "The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.",

author = "David, {Kim P} and Michael Alifrangis and Ali Salanti and Vestergaard, {Lasse S} and Anita R{\o}nn and Bygbjerg, {I B}",

note = "Keywords: Adult; Africa; Animals; Atovaquone; Bacterial Proteins; Chloroguanide; Cytochrome b Group; Denmark; Drug Resistance, Multiple; Drug Therapy, Combination; Ferritins; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Mutation; Naphthoquinones; Pharmacogenetics; Plasmodium falciparum; Polymerase Chain Reaction; Risk Assessment; Travel; Treatment Failure",

year = "2003",

language = "English",

volume = "35",

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journal = "Infectious Diseases",

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TY - JOUR

T1 - Atovaquone/proguanil resistance in Africa: a case report

AU - David, Kim P

AU - Alifrangis, Michael

AU - Salanti, Ali

AU - Vestergaard, Lasse S

AU - Rønn, Anita

AU - Bygbjerg, I B

N1 - Keywords: Adult; Africa; Animals; Atovaquone; Bacterial Proteins; Chloroguanide; Cytochrome b Group; Denmark; Drug Resistance, Multiple; Drug Therapy, Combination; Ferritins; Humans; Malaria, Falciparum; Male; Microbial Sensitivity Tests; Mutation; Naphthoquinones; Pharmacogenetics; Plasmodium falciparum; Polymerase Chain Reaction; Risk Assessment; Travel; Treatment Failure

PY - 2003

Y1 - 2003

N2 - The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.

AB - The Atovaquone/proguanil combination has quickly been established as an effective chemoprophylaxis for travellers to areas with chloroquineresistant Plasmodium falciparum malaria. We describe the molecular cause of the first reported case of primary Atovaquone/proguanil resistance observed in our department in a Plasmodium falciparum infected traveller returning from West Africa, and link our findings to other reports of resistance.

M3 - Journal article

C2 - 14723376

SN - 2374-4235

VL - 35

SP - 897

EP - 898

JO - Infectious Diseases

JF - Infectious Diseases

IS - 11-12

ER -

Atovaquone/proguanil resistance in Africa: a case report

Abstract

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