Atlases of cardiac fiber differential geometry

TY - GEN

T1 - Atlases of cardiac fiber differential geometry

AU - Piuze, Emmanuel

AU - Lombaert, Herve

AU - Sporring, Jon

AU - Strijkers, Gustav J.

AU - Bakermans, Adrianus J.

AU - Siddiqi, Kaleem

N1 - Conference code: 7

PY - 2013

Y1 - 2013

N2 - Studies of intra-species cardiac fiber variability tend to focus on first-order measures such as local fiber orientation. Recent work has shown that myofibers bundle locally into a particular type of minimal surface, the generalized helicoid model (GHM), which is described by three biologically meaningful curvature parameters. In order to allow intra-species comparisons, a typical strategy is to divide the parameters of the generalized helicoid by heart diameter. This normalization does not compensate for variability in myocardial shape between subjects and makes interpretation of intra-species results difficult. This paper proposes to use an atlas of rat and dog myocardium, obtained using diffeomorphic groupwise Log-demons, to register all hearts in a common reference shape to perform the normalization. In this common space the GHM is estimated for all hearts and compared using an improved fitting method. Our results demonstrate improved consistency between GHM curvatures within a species and support a direct relation between myocardial shape and fiber curvature in the heart.

AB - Studies of intra-species cardiac fiber variability tend to focus on first-order measures such as local fiber orientation. Recent work has shown that myofibers bundle locally into a particular type of minimal surface, the generalized helicoid model (GHM), which is described by three biologically meaningful curvature parameters. In order to allow intra-species comparisons, a typical strategy is to divide the parameters of the generalized helicoid by heart diameter. This normalization does not compensate for variability in myocardial shape between subjects and makes interpretation of intra-species results difficult. This paper proposes to use an atlas of rat and dog myocardium, obtained using diffeomorphic groupwise Log-demons, to register all hearts in a common reference shape to perform the normalization. In this common space the GHM is estimated for all hearts and compared using an improved fitting method. Our results demonstrate improved consistency between GHM curvatures within a species and support a direct relation between myocardial shape and fiber curvature in the heart.

U2 - 10.1007/978-3-642-38899-6_52

DO - 10.1007/978-3-642-38899-6_52

M3 - Article in proceedings

SN - 978-3-642-38898-9

T3 - Lecture notes in computer science

SP - 442

EP - 449

BT - Functional Imaging and Modeling of the Heart

A2 - Ourselin, Sébastien

A2 - Rueckert, Daniel

A2 - Smith, Nicolas

PB - Springer

T2 - 7th International Conference on Functional Imaging and Modeling of the Heart

Y2 - 20 June 2013 through 22 June 2013

ER -