Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture

Cong-Lin Liu; Holger Wemmelund; Yi Wang; Mengyang Liao; Jes S Lindholt; Soeren P Johnsen; Henrik Vestergaard; Cleverson Fernandes; Galina K Sukhova; Xiang Cheng; Jin-Ying Zhang; Chongzhe Yang; Xiaozhu Huang; Alan Daugherty; Bruce D Levy; Peter Libby; Guo-Ping Shi

doi:10.1161/atvbaha.115.306497

Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture

Cong-Lin Liu, Holger Wemmelund, Yi Wang, Mengyang Liao, Jes S Lindholt, Soeren P Johnsen, Henrik Vestergaard, Cleverson Fernandes, Galina K Sukhova, Xiang Cheng, Jin-Ying Zhang, Chongzhe Yang, Xiaozhu Huang, Alan Daugherty, Bruce D Levy, Peter Libby, Guo-Ping Shi

12 Citations (Scopus)

Abstract

Objective - Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results - Databases analyzed included Danish National Registry of Patients, a population-based nationwide case-control study included all patients with ruptured AAA and age- and sex-matched AAA controls without rupture in Denmark from 1996 to 2012; Viborg vascular trial, subgroup study of participants from the population-based randomized Viborg vascular screening trial. Patients with asthma were categorized by hospital diagnosis, bronchodilator use, and the recorded use of other anti-asthma prescription medications. Logistic regression models were fitted to determine whether asthma associated with the risk of ruptured AAA in Danish National Registry of Patients and an independent risk of having an AAA at screening in the Viborg vascular trial. From the Danish National Registry of Patients study, asthma diagnosed <1 year or 6 months before the index date increased the risk of AAA rupture before (odds ratio [OR]=1.60-2.12) and after (OR=1.51-2.06) adjusting for AAA comorbidities. Use of bronchodilators elevated the risk of AAA rupture from ever use to within 90 days from the index date, before (OR=1.10-1.37) and after (OR=1.10-1.31) adjustment. Patients prescribed anti-asthma drugs also showed an increased risk of rupture before (OR=1.12-1.79) and after (OR=1.09-1.48) the same adjustment. In Viborg vascular trial, anti-asthmatic medication use associated with increased risk of AAA before (OR=1.45) or after adjustment for smoking (OR=1.45) or other risk factors (OR=1.46). Conclusions - Recent active asthma increased risk of AAA and ruptured AAA. These findings document and furnish novel links between airway disease and AAA, 2 common diseases that share inflammatory aspects.

Original language	English
Journal	Arteriosclerosis, Thrombosis, and Vascular Biology
Volume	36
Issue number	3
Pages (from-to)	570-8
Number of pages	9
ISSN	1079-5642
DOIs	https://doi.org/10.1161/atvbaha.115.306497
Publication status	Published - 1 Mar 2016

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Liu, C.-L., Wemmelund, H., Wang, Y., Liao, M., Lindholt, J. S., Johnsen, S. P., Vestergaard, H., Fernandes, C., Sukhova, G. K., Cheng, X., Zhang, J.-Y., Yang, C., Huang, X., Daugherty, A., Levy, B. D., Libby, P., & Shi, G.-P. (2016). Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture. Arteriosclerosis, Thrombosis, and Vascular Biology, 36(3), 570-8. https://doi.org/10.1161/atvbaha.115.306497

Liu, C-L, Wemmelund, H, Wang, Y, Liao, M, Lindholt, JS, Johnsen, SP, Vestergaard, H, Fernandes, C, Sukhova, GK, Cheng, X, Zhang, J-Y, Yang, C, Huang, X, Daugherty, A, Levy, BD, Libby, P & Shi, G-P 2016, 'Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture', Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 36, no. 3, pp. 570-8. https://doi.org/10.1161/atvbaha.115.306497

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title = "Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture",

abstract = "Objective - Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results - Databases analyzed included Danish National Registry of Patients, a population-based nationwide case-control study included all patients with ruptured AAA and age- and sex-matched AAA controls without rupture in Denmark from 1996 to 2012; Viborg vascular trial, subgroup study of participants from the population-based randomized Viborg vascular screening trial. Patients with asthma were categorized by hospital diagnosis, bronchodilator use, and the recorded use of other anti-asthma prescription medications. Logistic regression models were fitted to determine whether asthma associated with the risk of ruptured AAA in Danish National Registry of Patients and an independent risk of having an AAA at screening in the Viborg vascular trial. From the Danish National Registry of Patients study, asthma diagnosed <1 year or 6 months before the index date increased the risk of AAA rupture before (odds ratio [OR]=1.60-2.12) and after (OR=1.51-2.06) adjusting for AAA comorbidities. Use of bronchodilators elevated the risk of AAA rupture from ever use to within 90 days from the index date, before (OR=1.10-1.37) and after (OR=1.10-1.31) adjustment. Patients prescribed anti-asthma drugs also showed an increased risk of rupture before (OR=1.12-1.79) and after (OR=1.09-1.48) the same adjustment. In Viborg vascular trial, anti-asthmatic medication use associated with increased risk of AAA before (OR=1.45) or after adjustment for smoking (OR=1.45) or other risk factors (OR=1.46). Conclusions - Recent active asthma increased risk of AAA and ruptured AAA. These findings document and furnish novel links between airway disease and AAA, 2 common diseases that share inflammatory aspects.",

author = "Cong-Lin Liu and Holger Wemmelund and Yi Wang and Mengyang Liao and Lindholt, {Jes S} and Johnsen, {Soeren P} and Henrik Vestergaard and Cleverson Fernandes and Sukhova, {Galina K} and Xiang Cheng and Jin-Ying Zhang and Chongzhe Yang and Xiaozhu Huang and Alan Daugherty and Levy, {Bruce D} and Peter Libby and Guo-Ping Shi",

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language = "English",

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T1 - Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture

AU - Liu, Cong-Lin

AU - Wemmelund, Holger

AU - Wang, Yi

AU - Liao, Mengyang

AU - Lindholt, Jes S

AU - Johnsen, Soeren P

AU - Vestergaard, Henrik

AU - Fernandes, Cleverson

AU - Sukhova, Galina K

AU - Cheng, Xiang

AU - Zhang, Jin-Ying

AU - Yang, Chongzhe

AU - Huang, Xiaozhu

AU - Daugherty, Alan

AU - Levy, Bruce D

AU - Libby, Peter

AU - Shi, Guo-Ping

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Objective - Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results - Databases analyzed included Danish National Registry of Patients, a population-based nationwide case-control study included all patients with ruptured AAA and age- and sex-matched AAA controls without rupture in Denmark from 1996 to 2012; Viborg vascular trial, subgroup study of participants from the population-based randomized Viborg vascular screening trial. Patients with asthma were categorized by hospital diagnosis, bronchodilator use, and the recorded use of other anti-asthma prescription medications. Logistic regression models were fitted to determine whether asthma associated with the risk of ruptured AAA in Danish National Registry of Patients and an independent risk of having an AAA at screening in the Viborg vascular trial. From the Danish National Registry of Patients study, asthma diagnosed <1 year or 6 months before the index date increased the risk of AAA rupture before (odds ratio [OR]=1.60-2.12) and after (OR=1.51-2.06) adjusting for AAA comorbidities. Use of bronchodilators elevated the risk of AAA rupture from ever use to within 90 days from the index date, before (OR=1.10-1.37) and after (OR=1.10-1.31) adjustment. Patients prescribed anti-asthma drugs also showed an increased risk of rupture before (OR=1.12-1.79) and after (OR=1.09-1.48) the same adjustment. In Viborg vascular trial, anti-asthmatic medication use associated with increased risk of AAA before (OR=1.45) or after adjustment for smoking (OR=1.45) or other risk factors (OR=1.46). Conclusions - Recent active asthma increased risk of AAA and ruptured AAA. These findings document and furnish novel links between airway disease and AAA, 2 common diseases that share inflammatory aspects.

AB - Objective - Both asthma and abdominal aortic aneurysms (AAA) involve inflammation. It remains unknown whether these diseases interact. Approach and Results - Databases analyzed included Danish National Registry of Patients, a population-based nationwide case-control study included all patients with ruptured AAA and age- and sex-matched AAA controls without rupture in Denmark from 1996 to 2012; Viborg vascular trial, subgroup study of participants from the population-based randomized Viborg vascular screening trial. Patients with asthma were categorized by hospital diagnosis, bronchodilator use, and the recorded use of other anti-asthma prescription medications. Logistic regression models were fitted to determine whether asthma associated with the risk of ruptured AAA in Danish National Registry of Patients and an independent risk of having an AAA at screening in the Viborg vascular trial. From the Danish National Registry of Patients study, asthma diagnosed <1 year or 6 months before the index date increased the risk of AAA rupture before (odds ratio [OR]=1.60-2.12) and after (OR=1.51-2.06) adjusting for AAA comorbidities. Use of bronchodilators elevated the risk of AAA rupture from ever use to within 90 days from the index date, before (OR=1.10-1.37) and after (OR=1.10-1.31) adjustment. Patients prescribed anti-asthma drugs also showed an increased risk of rupture before (OR=1.12-1.79) and after (OR=1.09-1.48) the same adjustment. In Viborg vascular trial, anti-asthmatic medication use associated with increased risk of AAA before (OR=1.45) or after adjustment for smoking (OR=1.45) or other risk factors (OR=1.46). Conclusions - Recent active asthma increased risk of AAA and ruptured AAA. These findings document and furnish novel links between airway disease and AAA, 2 common diseases that share inflammatory aspects.

U2 - 10.1161/atvbaha.115.306497

DO - 10.1161/atvbaha.115.306497

M3 - Journal article

C2 - 26868210

SN - 1079-5642

VL - 36

SP - 570

EP - 578

JO - Arteriosclerosis, Thrombosis, and Vascular Biology

JF - Arteriosclerosis, Thrombosis, and Vascular Biology

IS - 3

ER -

Asthma Associates With Human Abdominal Aortic Aneurysm and Rupture

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