Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

Jose R Castillo-Mancilla; Andrew N Phillips; James D Neaton; Jacqueline Neuhaus; Simon Collins; Sharon Mannheimer; Sarah Pett; Veronique Touzeau-Römer; Mark N Polizzotto; Jens D Lundgren; Edward M Gardner; INSIGHT SMART Study Group

doi:10.1093/ofid/ofx275

Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

Jose R Castillo-Mancilla, Andrew N Phillips, James D Neaton, Jacqueline Neuhaus, Simon Collins, Sharon Mannheimer, Sarah Pett, Veronique Touzeau-Römer, Mark N Polizzotto, Jens D Lundgren, Edward M Gardner, INSIGHT SMART Study Group

Department of Clinical Medicine

7 Citations (Scopus)

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Abstract

Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.

Original language	English
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	1
Pages (from-to)	ofx275
Number of pages	5
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofx275
Publication status	Published - 1 Jan 2018

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Castillo-Mancilla, J. R., Phillips, A. N., Neaton, J. D., Neuhaus, J., Collins, S., Mannheimer, S., Pett, S., Touzeau-Römer, V., Polizzotto, M. N., Lundgren, J. D., Gardner, E. M., & INSIGHT SMART Study Group (2018). Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study. Open Forum Infectious Diseases, 5(1), ofx275. https://doi.org/10.1093/ofid/ofx275

Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study. / Castillo-Mancilla, Jose R; Phillips, Andrew N; Neaton, James D et al.

In: Open Forum Infectious Diseases, Vol. 5, No. 1, 01.01.2018, p. ofx275.

Research output: Contribution to journal › Journal article › Research › peer-review

Castillo-Mancilla, JR, Phillips, AN, Neaton, JD, Neuhaus, J, Collins, S, Mannheimer, S, Pett, S, Touzeau-Römer, V, Polizzotto, MN, Lundgren, JD, Gardner, EM & INSIGHT SMART Study Group 2018, 'Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study', Open Forum Infectious Diseases, vol. 5, no. 1, pp. ofx275. https://doi.org/10.1093/ofid/ofx275

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title = "Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study",

abstract = "Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.",

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AU - Castillo-Mancilla, Jose R

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AU - Neuhaus, Jacqueline

AU - Collins, Simon

AU - Mannheimer, Sharon

AU - Pett, Sarah

AU - Touzeau-Römer, Veronique

AU - Polizzotto, Mark N

AU - Lundgren, Jens D

AU - Gardner, Edward M

AU - INSIGHT SMART Study Group

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AB - Suboptimal (ie, <100%) antiretroviral therapy (ART) adherence has been associated with heightened inflammation in cohort studies, even among people with virologic suppression. We aimed to evaluate this association among participants in the Strategies for Management of Antiretroviral Therapy (SMART) study who had virologic suppression (HIV-1 VL < 200 copies/mL) at enrollment. Based on self-reported adherence (7-day recall), plasma concentrations of interleukin 6 and D-dimer were 9% (95% confidence interval [CI], 1%-18%; P = .02) and 11% (95% CI, 1%-22%; P = .03) higher in participants who reported suboptimal vs 100% adherence, respectively. These findings confirm previous observations and support the hypothesis that suboptimal ART adherence, even in the context of virologic suppression, may have significant biological consequences. ClinicalTrials.gov number NCT00027352.

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Association of Suboptimal Antiretroviral Therapy Adherence With Inflammation in Virologically Suppressed Individuals Enrolled in the SMART Study

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