Association between prenatal exposure to analgesics and risk of schizophrenia

Holger J Sørensen; Erik Lykke Mortensen; June M Reinisch; Sarnoff A Mednick

doi:http://dx.doi.org/10.1192/bjp.185.5.366

Association between prenatal exposure to analgesics and risk of schizophrenia

Holger J Sørensen, Erik Lykke Mortensen, June M Reinisch, Sarnoff A Mednick

Department of Public Health

31 Citations (Scopus)

Abstract

BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

Original language	English
Journal	British Journal of Psychiatry
Volume	185
Issue number	185
Pages (from-to)	366-371
Number of pages	5
ISSN	0007-1250
DOIs	https://doi.org/10.1192/bjp.185.5.366
Publication status	Published - 2004

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@article{2cc5958074c411dbbee902004c4f4f50,

title = "Association between prenatal exposure to analgesics and risk of schizophrenia",

abstract = "BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.",

author = "S{\o}rensen, {Holger J} and Mortensen, {Erik Lykke} and Reinisch, {June M} and Mednick, {Sarnoff A}",

note = "Keywords: Adult; Analgesics; Cohort Studies; Female; Humans; Male; Odds Ratio; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Risk Factors; Schizophrenia",

year = "2004",

doi = "http://dx.doi.org/10.1192/bjp.185.5.366",

language = "English",

volume = "185",

pages = "366--371",

journal = "The Journal of mental science",

issn = "0960-5371",

publisher = "Royal College of Psychiatrists",

number = "185",

}

TY - JOUR

T1 - Association between prenatal exposure to analgesics and risk of schizophrenia

AU - Sørensen, Holger J

AU - Mortensen, Erik Lykke

AU - Reinisch, June M

AU - Mednick, Sarnoff A

N1 - Keywords: Adult; Analgesics; Cohort Studies; Female; Humans; Male; Odds Ratio; Pregnancy; Pregnancy Trimester, Second; Pregnancy Trimester, Third; Prenatal Exposure Delayed Effects; Risk Factors; Schizophrenia

PY - 2004

Y1 - 2004

N2 - BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

AB - BACKGROUND: Disturbances in the central nervous system originating during foetal life may increase the risk of schizophrenia. AIMS: To illuminate the hypothesis that prenatal exposure to analgesics may affect foetal neurodevelopment, leading to increased risk of schizophrenia in adulthood. METHOD: Using data from the Copenhagen Perinatal Cohort and from the Danish Psychiatric Central Register, we studied the relationship between prenatal exposure to analgesics and the risk of schizophrenia. The effect of prenatal exposure was adjusted for parental history of schizophrenia, second-trimester viral infections, concomitant drug treatment during pregnancy, an index of pregnancy complications, parental social status and parental age. RESULTS: In a risk set of 7999 individuals, 116 cases of schizophrenia were found (1.5%). Prenatal exposure to analgesics in the second trimester was associated with an elevated risk (adjusted odds ratio 4.75, 95% CI1.9-12.0). Independent of the covariates, the effect remained statistically significant. CONCLUSIONS: Independent of a wide range of possible confounders, a significant association between second-trimester exposure to analgesics and increased risk of schizophrenia was observed.

U2 - http://dx.doi.org/10.1192/bjp.185.5.366

DO - http://dx.doi.org/10.1192/bjp.185.5.366

M3 - Journal article

SN - 0960-5371

VL - 185

SP - 366

EP - 371

JO - The Journal of mental science

JF - The Journal of mental science

IS - 185

ER -

Association between prenatal exposure to analgesics and risk of schizophrenia

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