Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

Martine Paquette; Yascara Grisel Luna Saavedra; Ann Chamberland; Annik Prat; Dirk Lund Christensen; Fannie Lajeunesse-Trempe; Lydia Kaduka; Nabil G. Seidah; Robert Dufour; Alexis Baass

doi:10.1089/met.2017.0027

Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

Martine Paquette, Yascara Grisel Luna Saavedra, Ann Chamberland, Annik Prat, Dirk Lund Christensen, Fannie Lajeunesse-Trempe, Lydia Kaduka, Nabil G. Seidah, Robert Dufour, Alexis Baass^*

^*Corresponding author for this work

Department of Public Health

9 Citations (Scopus)

Abstract

Background: The prevalence of metabolic syndrome (MetS) has increased dramatically in low- and middle-income countries. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in low-density lipoprotein receptor degradation, but its relationship with metabolic parameters is still poorly understood. We aimed to investigate the association between plasma PCSK9 and metabolic parameters in a Kenyan cohort. Methods: Total plasma PCSK9 levels were measured in 2016 by an in-house enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody. The International Diabetes Federation (IDF) 2009 consensus statement criteria were used to assess the presence of MetS. Results: In 1338 Kenyans, 11% of the cohort had ≥3 MetS criteria. Total plasma PCSK9 concentration was significantly higher in subjects with MetS than in the non-MetS group (166.8 ± 4.4 vs. 148.0 ± 1.3, P < 0.0001). A progressive increase in circulating PCSK9 was observed when subjects were stratified according to the number of MetS criteria (<3, 3, 4, or 5) [P of the analysis of variance (ANOVA) <0.0001]. In a model corrected for age, sex, lifestyle factors, and body mass index, PCSK9 concentration was a significant predictor of all MetS criteria taken individually, except for waist circumference. Plasma PCSK9 levels were significantly associated with low-density lipoprotein cholesterol, but the strongest association was seen with triglycerides even after multiple adjustments. Conclusions: The presence of MetS was significantly associated with the PCSK9 concentration. Further studies are needed to provide a molecular connection between PCSK9 and insulin, as well as triglyceride metabolism.

Original language	English
Journal	Metabolic Syndrome and Related Disorders
Volume	15
Issue number	8
Pages (from-to)	423-429
Number of pages	7
ISSN	1540-4196
DOIs	https://doi.org/10.1089/met.2017.0027
Publication status	Published - 1 Oct 2017

Keywords

insulin
LDL-C
metabolic syndrome
PCSK9
sub-Saharan Africa
triglycerides

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1089/met.2017.0027

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Paquette, M., Luna Saavedra, Y. G., Chamberland, A., Prat, A., Christensen, D. L., Lajeunesse-Trempe, F., Kaduka, L., Seidah, N. G., Dufour, R., & Baass, A. (2017). Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population. Metabolic Syndrome and Related Disorders, 15(8), 423-429. https://doi.org/10.1089/met.2017.0027

Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population. / Paquette, Martine; Luna Saavedra, Yascara Grisel; Chamberland, Ann et al.

In: Metabolic Syndrome and Related Disorders, Vol. 15, No. 8, 01.10.2017, p. 423-429.

Research output: Contribution to journal › Journal article › Research › peer-review

Paquette, M, Luna Saavedra, YG, Chamberland, A, Prat, A, Christensen, DL, Lajeunesse-Trempe, F, Kaduka, L, Seidah, NG, Dufour, R & Baass, A 2017, 'Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population', Metabolic Syndrome and Related Disorders, vol. 15, no. 8, pp. 423-429. https://doi.org/10.1089/met.2017.0027

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title = "Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population",

abstract = "Background: The prevalence of metabolic syndrome (MetS) has increased dramatically in low- and middle-income countries. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in low-density lipoprotein receptor degradation, but its relationship with metabolic parameters is still poorly understood. We aimed to investigate the association between plasma PCSK9 and metabolic parameters in a Kenyan cohort. Methods: Total plasma PCSK9 levels were measured in 2016 by an in-house enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody. The International Diabetes Federation (IDF) 2009 consensus statement criteria were used to assess the presence of MetS. Results: In 1338 Kenyans, 11% of the cohort had ≥3 MetS criteria. Total plasma PCSK9 concentration was significantly higher in subjects with MetS than in the non-MetS group (166.8 ± 4.4 vs. 148.0 ± 1.3, P < 0.0001). A progressive increase in circulating PCSK9 was observed when subjects were stratified according to the number of MetS criteria (<3, 3, 4, or 5) [P of the analysis of variance (ANOVA) <0.0001]. In a model corrected for age, sex, lifestyle factors, and body mass index, PCSK9 concentration was a significant predictor of all MetS criteria taken individually, except for waist circumference. Plasma PCSK9 levels were significantly associated with low-density lipoprotein cholesterol, but the strongest association was seen with triglycerides even after multiple adjustments. Conclusions: The presence of MetS was significantly associated with the PCSK9 concentration. Further studies are needed to provide a molecular connection between PCSK9 and insulin, as well as triglyceride metabolism.",

keywords = "insulin, LDL-C, metabolic syndrome, PCSK9, sub-Saharan Africa, triglycerides",

author = "Martine Paquette and {Luna Saavedra}, {Yascara Grisel} and Ann Chamberland and Annik Prat and Christensen, {Dirk Lund} and Fannie Lajeunesse-Trempe and Lydia Kaduka and Seidah, {Nabil G.} and Robert Dufour and Alexis Baass",

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doi = "10.1089/met.2017.0027",

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T1 - Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

AU - Paquette, Martine

AU - Luna Saavedra, Yascara Grisel

AU - Chamberland, Ann

AU - Prat, Annik

AU - Christensen, Dirk Lund

AU - Lajeunesse-Trempe, Fannie

AU - Kaduka, Lydia

AU - Seidah, Nabil G.

AU - Dufour, Robert

AU - Baass, Alexis

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Background: The prevalence of metabolic syndrome (MetS) has increased dramatically in low- and middle-income countries. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in low-density lipoprotein receptor degradation, but its relationship with metabolic parameters is still poorly understood. We aimed to investigate the association between plasma PCSK9 and metabolic parameters in a Kenyan cohort. Methods: Total plasma PCSK9 levels were measured in 2016 by an in-house enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody. The International Diabetes Federation (IDF) 2009 consensus statement criteria were used to assess the presence of MetS. Results: In 1338 Kenyans, 11% of the cohort had ≥3 MetS criteria. Total plasma PCSK9 concentration was significantly higher in subjects with MetS than in the non-MetS group (166.8 ± 4.4 vs. 148.0 ± 1.3, P < 0.0001). A progressive increase in circulating PCSK9 was observed when subjects were stratified according to the number of MetS criteria (<3, 3, 4, or 5) [P of the analysis of variance (ANOVA) <0.0001]. In a model corrected for age, sex, lifestyle factors, and body mass index, PCSK9 concentration was a significant predictor of all MetS criteria taken individually, except for waist circumference. Plasma PCSK9 levels were significantly associated with low-density lipoprotein cholesterol, but the strongest association was seen with triglycerides even after multiple adjustments. Conclusions: The presence of MetS was significantly associated with the PCSK9 concentration. Further studies are needed to provide a molecular connection between PCSK9 and insulin, as well as triglyceride metabolism.

AB - Background: The prevalence of metabolic syndrome (MetS) has increased dramatically in low- and middle-income countries. Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in low-density lipoprotein receptor degradation, but its relationship with metabolic parameters is still poorly understood. We aimed to investigate the association between plasma PCSK9 and metabolic parameters in a Kenyan cohort. Methods: Total plasma PCSK9 levels were measured in 2016 by an in-house enzyme-linked immunosorbent assay (ELISA) using a polyclonal antibody. The International Diabetes Federation (IDF) 2009 consensus statement criteria were used to assess the presence of MetS. Results: In 1338 Kenyans, 11% of the cohort had ≥3 MetS criteria. Total plasma PCSK9 concentration was significantly higher in subjects with MetS than in the non-MetS group (166.8 ± 4.4 vs. 148.0 ± 1.3, P < 0.0001). A progressive increase in circulating PCSK9 was observed when subjects were stratified according to the number of MetS criteria (<3, 3, 4, or 5) [P of the analysis of variance (ANOVA) <0.0001]. In a model corrected for age, sex, lifestyle factors, and body mass index, PCSK9 concentration was a significant predictor of all MetS criteria taken individually, except for waist circumference. Plasma PCSK9 levels were significantly associated with low-density lipoprotein cholesterol, but the strongest association was seen with triglycerides even after multiple adjustments. Conclusions: The presence of MetS was significantly associated with the PCSK9 concentration. Further studies are needed to provide a molecular connection between PCSK9 and insulin, as well as triglyceride metabolism.

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KW - LDL-C

KW - metabolic syndrome

KW - PCSK9

KW - sub-Saharan Africa

KW - triglycerides

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SN - 1540-4196

VL - 15

SP - 423

EP - 429

JO - Metabolic Syndrome and Related Disorders

JF - Metabolic Syndrome and Related Disorders

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ER -

Association between Plasma Proprotein Convertase Subtilisin/Kexin Type 9 and the Presence of Metabolic Syndrome in a Predominantly Rural-Based Sub-Saharan African Population

Abstract

Keywords

UN SDGs

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