Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.

Anders Rinnov Nielsen; Pernille Hojman; Christian Erikstrup; Christian Philip Fischer; Peter Plomgaard; Remi Mounier; Ole Hartvig Mortensen; Christa Broholm; Sarah Taudorf; Rikke Krogh-Madsen; Birgitte Lindegaard; Anne Marie Winther Petersen; Julie Gehl; Bente Klarlund Pedersen

doi:10.1210/jc.2007-2561

Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.

Anders Rinnov Nielsen, Pernille Hojman, Christian Erikstrup, Christian Philip Fischer, Peter Plomgaard, Remi Mounier, Ole Hartvig Mortensen, Christa Broholm, Sarah Taudorf, Rikke Krogh-Madsen, Birgitte Lindegaard, Anne Marie Winther Petersen, Julie Gehl, Bente Klarlund Pedersen

127 Citations (Scopus)

Abstract

Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.

Original language	English
Journal	Journal of Clinical Endocrinology and Metabolism
Volume	93
Issue number	11
Pages (from-to)	4486-93
Number of pages	7
ISSN	0021-972X
DOIs	https://doi.org/10.1210/jc.2007-2561
Publication status	Published - 2008

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10.1210/jc.2007-2561

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Nielsen, A. R., Hojman, P., Erikstrup, C., Fischer, C. P., Plomgaard, P., Mounier, R., Mortensen, O. H., Broholm, C., Taudorf, S., Krogh-Madsen, R., Lindegaard, B., Petersen, A. M. W., Gehl, J., & Pedersen, B. K. (2008). Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass. Journal of Clinical Endocrinology and Metabolism, 93(11), 4486-93. https://doi.org/10.1210/jc.2007-2561

Nielsen, AR, Hojman, P, Erikstrup, C, Fischer, CP, Plomgaard, P, Mounier, R, Mortensen, OH, Broholm, C, Taudorf, S, Krogh-Madsen, R, Lindegaard, B, Petersen, AMW, Gehl, J & Pedersen, BK 2008, 'Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.', Journal of Clinical Endocrinology and Metabolism, vol. 93, no. 11, pp. 4486-93. https://doi.org/10.1210/jc.2007-2561

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title = "Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.",

abstract = "Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.",

author = "Nielsen, {Anders Rinnov} and Pernille Hojman and Christian Erikstrup and Fischer, {Christian Philip} and Peter Plomgaard and Remi Mounier and Mortensen, {Ole Hartvig} and Christa Broholm and Sarah Taudorf and Rikke Krogh-Madsen and Birgitte Lindegaard and Petersen, {Anne Marie Winther} and Julie Gehl and Pedersen, {Bente Klarlund}",

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doi = "10.1210/jc.2007-2561",

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T1 - Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.

AU - Nielsen, Anders Rinnov

AU - Hojman, Pernille

AU - Erikstrup, Christian

AU - Fischer, Christian Philip

AU - Plomgaard, Peter

AU - Mounier, Remi

AU - Mortensen, Ole Hartvig

AU - Broholm, Christa

AU - Taudorf, Sarah

AU - Krogh-Madsen, Rikke

AU - Lindegaard, Birgitte

AU - Petersen, Anne Marie Winther

AU - Gehl, Julie

AU - Pedersen, Bente Klarlund

PY - 2008

Y1 - 2008

N2 - Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.

AB - Objective: IL-15 decreases lipid deposition in preadipocytes and decreases the mass of white adipose tissue in rats, indicating that IL-15 may take part in regulating this tissue. IL-15 is expressed in human skeletal muscle and skeletal muscle may be a source of plasma IL-15 and in this way regulate adipose tissue mass. Design: The relation between skeletal muscle IL-15 mRNA expression, plasma IL-15, and adipose tissue mass was studied in 199 humans divided into four groups on the basis of obesity and type 2 diabetes. Furthermore, using a DNA electrotransfer model, we assessed the effect of IL-15 overexpression in skeletal muscle of mice. Results: In humans, multiple regression analysis showed a negative association between plasma IL-15 and total fat mass (P < 0.05), trunk fat mass (P < 0.01), and percent fat mass (P < 0.05), independent of type 2 diabetes. Negative associations were also found between muscle IL-15 mRNA and obesity parameters. IL-15 overexpression in skeletal muscle of mice reduced trunk fat mass but not sc fat mass. Conclusions: Our results indicate that IL-15 may be a regulator of trunk fat mass.

U2 - 10.1210/jc.2007-2561

DO - 10.1210/jc.2007-2561

M3 - Journal article

C2 - 18697873

SN - 0021-972X

VL - 93

SP - 4486

EP - 4493

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

IS - 11

ER -

Association between Interleukin-15 and Obesity: Interleukin-15 as a Potential Regulator of Fat Mass.

Abstract

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