TY - JOUR
T1 - Association between global functioning at first schizophrenia diagnosis and treatment resistance
AU - Horsdal, Henriette T.
AU - Wimberley, Theresa
AU - Köhler-forsberg, Ole
AU - Baandrup, Lone
AU - Gasse, Christiane
PY - 2018/12
Y1 - 2018/12
N2 - Aim: Several factors such as age, gender, urbanicity and clinical treatment setting have been associated with treatment-resistant schizophrenia (TRS). We examined the association between the Global Assessment of Functioning (social Functioning [GAF-F]) score at first schizophrenia diagnosis and TRS and explored whether level of functioning could partially explain the known associations. Methods: A nationwide population-based cohort study among individuals, who had a GAF-F score at first schizophrenia diagnosis. We used adjusted Cox regression analysis to calculate hazard ratios (HRs). Results: Among 3252 individuals, severe functional impairment (GAF-F ≤ 30) was associated with TRS within 2 years after diagnosis (adjusted HR = 1.38 [95% confidence interval: 1.03-1.87). GAF-F had virtually no impact on the associations between investigated known risk factors and TRS. Conclusions: GAF-F was independently associated with TRS. Consideration of a global functioning score may help clinicians to detect treatment resistance earlier among individuals with schizophrenia.
AB - Aim: Several factors such as age, gender, urbanicity and clinical treatment setting have been associated with treatment-resistant schizophrenia (TRS). We examined the association between the Global Assessment of Functioning (social Functioning [GAF-F]) score at first schizophrenia diagnosis and TRS and explored whether level of functioning could partially explain the known associations. Methods: A nationwide population-based cohort study among individuals, who had a GAF-F score at first schizophrenia diagnosis. We used adjusted Cox regression analysis to calculate hazard ratios (HRs). Results: Among 3252 individuals, severe functional impairment (GAF-F ≤ 30) was associated with TRS within 2 years after diagnosis (adjusted HR = 1.38 [95% confidence interval: 1.03-1.87). GAF-F had virtually no impact on the associations between investigated known risk factors and TRS. Conclusions: GAF-F was independently associated with TRS. Consideration of a global functioning score may help clinicians to detect treatment resistance earlier among individuals with schizophrenia.
U2 - 10.1111/eip.2018.12.issue-6
DO - 10.1111/eip.2018.12.issue-6
M3 - Journal article
SN - 1751-7885
VL - 12
SP - 1198
EP - 1202
JO - Early Intervention in Psychiatry
JF - Early Intervention in Psychiatry
IS - 6
ER -