Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study

Karani S Vimaleswaran; Lars Ängquist; Rikke D Hansen; Daphne L van der A; Nabila Bouatia-Naji; Claus Holst; Anne Tjønneland; Kim Overvad; Marianne Uhre Jakobsen; Heiner Boeing; Karina Meidtner; Domenico Palli; Giovanna Masala; Wim H M Saris; Edith J M Feskens; Nicholas J Wareham; Thorkild I A Sørensen; Ruth J F Loos

doi:10.1038/oby.2012.49

Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study

Karani S Vimaleswaran, Lars Ängquist, Rikke D Hansen, Daphne L van der A, Nabila Bouatia-Naji, Claus Holst, Anne Tjønneland, Kim Overvad, Marianne Uhre Jakobsen, Heiner Boeing, Karina Meidtner, Domenico Palli, Giovanna Masala, Wim H M Saris, Edith J M Feskens, Nicholas J Wareham, Thorkild I A Sørensen, Ruth J F Loos

27 Citations (Scopus)

Abstract

Although FTO is an established obesity-susceptibility locus, it remains unknown whether it influences weight change in adult life and whether diet attenuates this association. Therefore, we investigated the association of FTO-rs9939609 with changes in weight and waist circumference (WC) during 6.8 years follow-up in a large-scale prospective study and examined whether these associations were modified by dietary energy percentage from fat, protein, carbohydrate, or glycemic index (GI). This study comprised data from five countries of European Prospective Investigation into Cancer and Nutrition (EPIC) and was designed as a case-cohort study for weight gain. Analyses included 11,091 individuals, of whom 5,584 were cases (age (SD), 47.6 (7.5) years), defined as those with the greatest unexplained annual weight gain during follow-up and 5,507 were noncases (48.0 (7.3) years), who were compared in our case-noncase (CNC) analyses. Furthermore, 6,566 individuals (47.9 (7.3) years) selected from the total sample (all noncases and 1,059 cases) formed the random subcohort (RSC), used for continuous trait analyses. Interactions were tested by including interaction terms in the models. In the RSC-analyses, FTO-rs9939609 was associated with BMI (β (SE), 0.17 (0.08) kg·m(-2)/allele; P = 0.034) and WC (0.47 (0.21) cm/allele; P = 0.026) at baseline, but not with weight change (5.55 (12.5) g·year(-1)/allele; P = 0.66) during follow up. In the CNC-analysis, FTO-rs9939609 was associated with increased risk of being a weight-gainer (OR: 1.1; P = 0.045). We observed no interaction between FTO-rs9939609 and dietary fat, protein and carbohydrate, and GI on BMI and WC at baseline or on change in weight and WC. FTO-rs9939609 is associated with BMI and WC at baseline, but association with weight gain is weak and only observed for extreme gain. Dietary factors did not influence the associations.

Original language	English
Journal	Obesity
Volume	20
Issue number	8
Pages (from-to)	1669-74
Number of pages	6
ISSN	1930-7381
DOIs	https://doi.org/10.1038/oby.2012.49
Publication status	Published - Aug 2012

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Vimaleswaran, K. S., Ängquist, L., Hansen, R. D., van der A, D. L., Bouatia-Naji, N., Holst, C., Tjønneland, A., Overvad, K., Jakobsen, M. U., Boeing, H., Meidtner, K., Palli, D., Masala, G., Saris, W. H. M., Feskens, E. J. M., Wareham, N. J., Sørensen, T. I. A., & Loos, R. J. F. (2012). Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study. Obesity, 20(8), 1669-74. https://doi.org/10.1038/oby.2012.49

Vimaleswaran, KS, Ängquist, L, Hansen, RD, van der A, DL, Bouatia-Naji, N, Holst, C, Tjønneland, A, Overvad, K, Jakobsen, MU, Boeing, H, Meidtner, K, Palli, D, Masala, G, Saris, WHM, Feskens, EJM, Wareham, NJ, Sørensen, TIA & Loos, RJF 2012, 'Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study', Obesity, vol. 20, no. 8, pp. 1669-74. https://doi.org/10.1038/oby.2012.49

@article{128010fcb0bd4424a730ea26c4411b41,

title = "Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study",

abstract = "Although FTO is an established obesity-susceptibility locus, it remains unknown whether it influences weight change in adult life and whether diet attenuates this association. Therefore, we investigated the association of FTO-rs9939609 with changes in weight and waist circumference (WC) during 6.8 years follow-up in a large-scale prospective study and examined whether these associations were modified by dietary energy percentage from fat, protein, carbohydrate, or glycemic index (GI). This study comprised data from five countries of European Prospective Investigation into Cancer and Nutrition (EPIC) and was designed as a case-cohort study for weight gain. Analyses included 11,091 individuals, of whom 5,584 were cases (age (SD), 47.6 (7.5) years), defined as those with the greatest unexplained annual weight gain during follow-up and 5,507 were noncases (48.0 (7.3) years), who were compared in our case-noncase (CNC) analyses. Furthermore, 6,566 individuals (47.9 (7.3) years) selected from the total sample (all noncases and 1,059 cases) formed the random subcohort (RSC), used for continuous trait analyses. Interactions were tested by including interaction terms in the models. In the RSC-analyses, FTO-rs9939609 was associated with BMI (β (SE), 0.17 (0.08) kg·m(-2)/allele; P = 0.034) and WC (0.47 (0.21) cm/allele; P = 0.026) at baseline, but not with weight change (5.55 (12.5) g·year(-1)/allele; P = 0.66) during follow up. In the CNC-analysis, FTO-rs9939609 was associated with increased risk of being a weight-gainer (OR: 1.1; P = 0.045). We observed no interaction between FTO-rs9939609 and dietary fat, protein and carbohydrate, and GI on BMI and WC at baseline or on change in weight and WC. FTO-rs9939609 is associated with BMI and WC at baseline, but association with weight gain is weak and only observed for extreme gain. Dietary factors did not influence the associations.",

author = "Vimaleswaran, {Karani S} and Lars {\"A}ngquist and Hansen, {Rikke D} and {van der A}, {Daphne L} and Nabila Bouatia-Naji and Claus Holst and Anne Tj{\o}nneland and Kim Overvad and Jakobsen, {Marianne Uhre} and Heiner Boeing and Karina Meidtner and Domenico Palli and Giovanna Masala and Saris, {Wim H M} and Feskens, {Edith J M} and Wareham, {Nicholas J} and S{\o}rensen, {Thorkild I A} and Loos, {Ruth J F}",

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language = "English",

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pages = "1669--74",

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T1 - Association between FTO variant and change in body weight and its interaction with dietary factors

T2 - the DiOGenes study

AU - Vimaleswaran, Karani S

AU - Ängquist, Lars

AU - Hansen, Rikke D

AU - van der A, Daphne L

AU - Bouatia-Naji, Nabila

AU - Holst, Claus

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Jakobsen, Marianne Uhre

AU - Boeing, Heiner

AU - Meidtner, Karina

AU - Palli, Domenico

AU - Masala, Giovanna

AU - Saris, Wim H M

AU - Feskens, Edith J M

AU - Wareham, Nicholas J

AU - Sørensen, Thorkild I A

AU - Loos, Ruth J F

PY - 2012/8

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N2 - Although FTO is an established obesity-susceptibility locus, it remains unknown whether it influences weight change in adult life and whether diet attenuates this association. Therefore, we investigated the association of FTO-rs9939609 with changes in weight and waist circumference (WC) during 6.8 years follow-up in a large-scale prospective study and examined whether these associations were modified by dietary energy percentage from fat, protein, carbohydrate, or glycemic index (GI). This study comprised data from five countries of European Prospective Investigation into Cancer and Nutrition (EPIC) and was designed as a case-cohort study for weight gain. Analyses included 11,091 individuals, of whom 5,584 were cases (age (SD), 47.6 (7.5) years), defined as those with the greatest unexplained annual weight gain during follow-up and 5,507 were noncases (48.0 (7.3) years), who were compared in our case-noncase (CNC) analyses. Furthermore, 6,566 individuals (47.9 (7.3) years) selected from the total sample (all noncases and 1,059 cases) formed the random subcohort (RSC), used for continuous trait analyses. Interactions were tested by including interaction terms in the models. In the RSC-analyses, FTO-rs9939609 was associated with BMI (β (SE), 0.17 (0.08) kg·m(-2)/allele; P = 0.034) and WC (0.47 (0.21) cm/allele; P = 0.026) at baseline, but not with weight change (5.55 (12.5) g·year(-1)/allele; P = 0.66) during follow up. In the CNC-analysis, FTO-rs9939609 was associated with increased risk of being a weight-gainer (OR: 1.1; P = 0.045). We observed no interaction between FTO-rs9939609 and dietary fat, protein and carbohydrate, and GI on BMI and WC at baseline or on change in weight and WC. FTO-rs9939609 is associated with BMI and WC at baseline, but association with weight gain is weak and only observed for extreme gain. Dietary factors did not influence the associations.

AB - Although FTO is an established obesity-susceptibility locus, it remains unknown whether it influences weight change in adult life and whether diet attenuates this association. Therefore, we investigated the association of FTO-rs9939609 with changes in weight and waist circumference (WC) during 6.8 years follow-up in a large-scale prospective study and examined whether these associations were modified by dietary energy percentage from fat, protein, carbohydrate, or glycemic index (GI). This study comprised data from five countries of European Prospective Investigation into Cancer and Nutrition (EPIC) and was designed as a case-cohort study for weight gain. Analyses included 11,091 individuals, of whom 5,584 were cases (age (SD), 47.6 (7.5) years), defined as those with the greatest unexplained annual weight gain during follow-up and 5,507 were noncases (48.0 (7.3) years), who were compared in our case-noncase (CNC) analyses. Furthermore, 6,566 individuals (47.9 (7.3) years) selected from the total sample (all noncases and 1,059 cases) formed the random subcohort (RSC), used for continuous trait analyses. Interactions were tested by including interaction terms in the models. In the RSC-analyses, FTO-rs9939609 was associated with BMI (β (SE), 0.17 (0.08) kg·m(-2)/allele; P = 0.034) and WC (0.47 (0.21) cm/allele; P = 0.026) at baseline, but not with weight change (5.55 (12.5) g·year(-1)/allele; P = 0.66) during follow up. In the CNC-analysis, FTO-rs9939609 was associated with increased risk of being a weight-gainer (OR: 1.1; P = 0.045). We observed no interaction between FTO-rs9939609 and dietary fat, protein and carbohydrate, and GI on BMI and WC at baseline or on change in weight and WC. FTO-rs9939609 is associated with BMI and WC at baseline, but association with weight gain is weak and only observed for extreme gain. Dietary factors did not influence the associations.

U2 - 10.1038/oby.2012.49

DO - 10.1038/oby.2012.49

M3 - Journal article

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SN - 1930-7381

VL - 20

SP - 1669

EP - 1674

JO - Obesity

JF - Obesity

IS - 8

ER -

Association between FTO variant and change in body weight and its interaction with dietary factors: the DiOGenes study

Abstract

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