Abstract
Several studies indicate genetic involvement of Th2 cytokines in allergic diseases. Interleukin (IL)-13 has been mapped to the cytokine cluster on chromosome 5q31-33, which has been associated with atopic conditions. Recently, an association was reported between the T allele in a promoter polymorphism in the IL-13 gene (C to T exchange) at position -1055 and allergic asthma in a population study in the Netherlands. This observation was apparently confirmed in a case-control study using probands and spouses from a Dutch asthma family study, but the polymorphism in that study was reported to occur at position -1111. In the present study, we established that this polymorphism is located at position -1024 relative to the ATG translation initiation codon, and investigated whether it confers a genetic predisposition to atopic conditions and the Th1 condition multiple sclerosis (MS) in Caucasian subjects. We confirmed the association between the IL-13 -1024TT genoype and inhalation allergy (P = 2.4E-02). By combining the data from the three studies, we demonstrated a strong association (P = 1.09E-05) between the IL-13 -1024 marker and inhalation allergy. Furthermore, we showed for the first time that this association also exists in atopic dermatitis (P = 2.0E-02). No association with MS was found.
| Original language | English |
|---|---|
| Journal | European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics |
| Volume | 30 |
| Issue number | 5 |
| Pages (from-to) | 355-9 |
| Number of pages | 5 |
| ISSN | 0960-7420 |
| Publication status | Published - Oct 2003 |
Keywords
- Base Sequence
- Genetic Predisposition to Disease
- Humans
- Hypersensitivity, Immediate
- Immunoglobulin E
- Interleukin-13
- Molecular Sequence Data
- Multiple Sclerosis
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Promoter Regions, Genetic
- Th1 Cells
- Th2 Cells