Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals

Sara V Greve; Marie K Blicher; Adam Blyme; Thomas Sehestedt; Tine W Hansen; Susanne Rassmusen; Julie K K Vishram; Hans Ibsen; Christian Torp-Pedersen; Michael H Olsen

doi:10.1097/hjh.0000000000000147

Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals

Sara V Greve, Marie K Blicher, Adam Blyme, Thomas Sehestedt, Tine W Hansen, Susanne Rassmusen, Julie K K Vishram, Hans Ibsen, Christian Torp-Pedersen, Michael H Olsen

Department of Clinical Medicine

8 Citations (Scopus)

Abstract

METHOD: Two thousand and fifty-nine healthy individuals aged 41, 51, 61 and 71 years examined in 1993, were divided in age, SCORE and Framingham risk score (FRS) groups. Subclinical vascular damage (SVD) was defined as carotid-femoral pulse wave velocity (cfPWV) at least 12m/s, carotid atherosclerotic plaques or albuminuria defined as urine albumin/creatinine ratio at least 90th percentile of 0.73/1.06mg/mmol men/women. In 2006, the composite endpoint (CEP) of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for ischemic heart disease was recorded (n=229). RESULTS: With increasing age, SCORE or FRS risk group, prevalence of cfPWV at least 12m/s (5.2, 14.5, 35.3, 53.5% or 4.4, 15.6, 50.9, 66.1% or 4.0, 9.5, 32.1, 56.1%), atherosclerotic plaque (4.0, 19.0, 35.3, 53.5% or 3.5, 16.8, 43.7, 55.9%, or 6.6, 7.6, 9.8, 20.0%) and albuminuria (7.9, 8.7, 11.4, 20.6% or 7.9, 8.2, 16.6, 19.5% or 6.6, 7.6, 9.8, 20.0%) increased, all P<0.001.CEP was associated with albuminuria in individuals aged 61 or 71 years, with moderate or very high SCORE or intermediate or high FRS (all P<0.05), with atherosclerotic plaques in individuals aged 41, 51 or 61 years, with moderate SCORE or with high-intermediate or high FRS (all P<0.01), and with cfPWV at least 12m/s in individuals aged 51 years (P<0.001) or high FRS (P<0.05). Presence of at least one SVD was significantly associated with an increased risk in individuals aged 51 [hazard ratio 2.7 (1.6-4.8)] and 61 years [hazard ratio 2.7 (1.5-4.7)], moderate [hazard ratio 2.4 (1.6-3.7)] or high SCORE risk group [hazard ratio 2.3 (1.2-4.7)] and low-intermediate [hazard ratio 3.3 (1.5-7.0)], high-intermediate [hazard ratio 2.3 (1.5-3.5)] and high FRS risk group [hazard ratio 2.0 (1.4-3.0)]. CONCLUSION: SVD and especially atherosclerotic plaques or urine albumin/creatinine ratio (UACR) at least 0.73/1.06mg/mmol (men/women) added prognostic information in individuals aged 51 or 61 years or with moderate or intermediate risk.

Original language	English
Journal	Journal of Hypertension
Volume	32
Issue number	5
Pages (from-to)	1034-41
Number of pages	7
ISSN	0263-6352
DOIs	https://doi.org/10.1097/hjh.0000000000000147
Publication status	Published - May 2014

Keywords

Age Factors
Albuminuria
Atherosclerosis
Humans
Prognosis
Pulse Wave Analysis
Risk Factors

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10.1097/hjh.0000000000000147

Cite this

Greve, S. V., Blicher, M. K., Blyme, A., Sehestedt, T., Hansen, T. W., Rassmusen, S., Vishram, J. K. K., Ibsen, H., Torp-Pedersen, C., & Olsen, M. H. (2014). Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals. Journal of Hypertension, 32(5), 1034-41. https://doi.org/10.1097/hjh.0000000000000147

Greve, SV, Blicher, MK, Blyme, A, Sehestedt, T, Hansen, TW, Rassmusen, S, Vishram, JKK, Ibsen, H, Torp-Pedersen, C & Olsen, MH 2014, 'Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals', Journal of Hypertension, vol. 32, no. 5, pp. 1034-41. https://doi.org/10.1097/hjh.0000000000000147

@article{17c7e4c05999490ab6cbb53f1c48e92a,

title = "Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals",

abstract = "METHOD: Two thousand and fifty-nine healthy individuals aged 41, 51, 61 and 71 years examined in 1993, were divided in age, SCORE and Framingham risk score (FRS) groups. Subclinical vascular damage (SVD) was defined as carotid-femoral pulse wave velocity (cfPWV) at least 12m/s, carotid atherosclerotic plaques or albuminuria defined as urine albumin/creatinine ratio at least 90th percentile of 0.73/1.06mg/mmol men/women. In 2006, the composite endpoint (CEP) of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for ischemic heart disease was recorded (n=229). RESULTS: With increasing age, SCORE or FRS risk group, prevalence of cfPWV at least 12m/s (5.2, 14.5, 35.3, 53.5% or 4.4, 15.6, 50.9, 66.1% or 4.0, 9.5, 32.1, 56.1%), atherosclerotic plaque (4.0, 19.0, 35.3, 53.5% or 3.5, 16.8, 43.7, 55.9%, or 6.6, 7.6, 9.8, 20.0%) and albuminuria (7.9, 8.7, 11.4, 20.6% or 7.9, 8.2, 16.6, 19.5% or 6.6, 7.6, 9.8, 20.0%) increased, all P<0.001.CEP was associated with albuminuria in individuals aged 61 or 71 years, with moderate or very high SCORE or intermediate or high FRS (all P<0.05), with atherosclerotic plaques in individuals aged 41, 51 or 61 years, with moderate SCORE or with high-intermediate or high FRS (all P<0.01), and with cfPWV at least 12m/s in individuals aged 51 years (P<0.001) or high FRS (P<0.05). Presence of at least one SVD was significantly associated with an increased risk in individuals aged 51 [hazard ratio 2.7 (1.6-4.8)] and 61 years [hazard ratio 2.7 (1.5-4.7)], moderate [hazard ratio 2.4 (1.6-3.7)] or high SCORE risk group [hazard ratio 2.3 (1.2-4.7)] and low-intermediate [hazard ratio 3.3 (1.5-7.0)], high-intermediate [hazard ratio 2.3 (1.5-3.5)] and high FRS risk group [hazard ratio 2.0 (1.4-3.0)]. CONCLUSION: SVD and especially atherosclerotic plaques or urine albumin/creatinine ratio (UACR) at least 0.73/1.06mg/mmol (men/women) added prognostic information in individuals aged 51 or 61 years or with moderate or intermediate risk.",

keywords = "Age Factors, Albuminuria, Atherosclerosis, Humans, Prognosis, Pulse Wave Analysis, Risk Factors",

author = "Greve, {Sara V} and Blicher, {Marie K} and Adam Blyme and Thomas Sehestedt and Hansen, {Tine W} and Susanne Rassmusen and Vishram, {Julie K K} and Hans Ibsen and Christian Torp-Pedersen and Olsen, {Michael H}",

year = "2014",

month = may,

doi = "10.1097/hjh.0000000000000147",

language = "English",

volume = "32",

pages = "1034--41",

journal = "Journal of Hypertension",

issn = "0263-6352",

publisher = "Lippincott Williams & Wilkins, Ltd.",

number = "5",

}

TY - JOUR

T1 - Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals

AU - Greve, Sara V

AU - Blicher, Marie K

AU - Blyme, Adam

AU - Sehestedt, Thomas

AU - Hansen, Tine W

AU - Rassmusen, Susanne

AU - Vishram, Julie K K

AU - Ibsen, Hans

AU - Torp-Pedersen, Christian

AU - Olsen, Michael H

PY - 2014/5

Y1 - 2014/5

N2 - METHOD: Two thousand and fifty-nine healthy individuals aged 41, 51, 61 and 71 years examined in 1993, were divided in age, SCORE and Framingham risk score (FRS) groups. Subclinical vascular damage (SVD) was defined as carotid-femoral pulse wave velocity (cfPWV) at least 12m/s, carotid atherosclerotic plaques or albuminuria defined as urine albumin/creatinine ratio at least 90th percentile of 0.73/1.06mg/mmol men/women. In 2006, the composite endpoint (CEP) of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for ischemic heart disease was recorded (n=229). RESULTS: With increasing age, SCORE or FRS risk group, prevalence of cfPWV at least 12m/s (5.2, 14.5, 35.3, 53.5% or 4.4, 15.6, 50.9, 66.1% or 4.0, 9.5, 32.1, 56.1%), atherosclerotic plaque (4.0, 19.0, 35.3, 53.5% or 3.5, 16.8, 43.7, 55.9%, or 6.6, 7.6, 9.8, 20.0%) and albuminuria (7.9, 8.7, 11.4, 20.6% or 7.9, 8.2, 16.6, 19.5% or 6.6, 7.6, 9.8, 20.0%) increased, all P<0.001.CEP was associated with albuminuria in individuals aged 61 or 71 years, with moderate or very high SCORE or intermediate or high FRS (all P<0.05), with atherosclerotic plaques in individuals aged 41, 51 or 61 years, with moderate SCORE or with high-intermediate or high FRS (all P<0.01), and with cfPWV at least 12m/s in individuals aged 51 years (P<0.001) or high FRS (P<0.05). Presence of at least one SVD was significantly associated with an increased risk in individuals aged 51 [hazard ratio 2.7 (1.6-4.8)] and 61 years [hazard ratio 2.7 (1.5-4.7)], moderate [hazard ratio 2.4 (1.6-3.7)] or high SCORE risk group [hazard ratio 2.3 (1.2-4.7)] and low-intermediate [hazard ratio 3.3 (1.5-7.0)], high-intermediate [hazard ratio 2.3 (1.5-3.5)] and high FRS risk group [hazard ratio 2.0 (1.4-3.0)]. CONCLUSION: SVD and especially atherosclerotic plaques or urine albumin/creatinine ratio (UACR) at least 0.73/1.06mg/mmol (men/women) added prognostic information in individuals aged 51 or 61 years or with moderate or intermediate risk.

AB - METHOD: Two thousand and fifty-nine healthy individuals aged 41, 51, 61 and 71 years examined in 1993, were divided in age, SCORE and Framingham risk score (FRS) groups. Subclinical vascular damage (SVD) was defined as carotid-femoral pulse wave velocity (cfPWV) at least 12m/s, carotid atherosclerotic plaques or albuminuria defined as urine albumin/creatinine ratio at least 90th percentile of 0.73/1.06mg/mmol men/women. In 2006, the composite endpoint (CEP) of cardiovascular death, nonfatal myocardial infarction, nonfatal stroke and hospitalization for ischemic heart disease was recorded (n=229). RESULTS: With increasing age, SCORE or FRS risk group, prevalence of cfPWV at least 12m/s (5.2, 14.5, 35.3, 53.5% or 4.4, 15.6, 50.9, 66.1% or 4.0, 9.5, 32.1, 56.1%), atherosclerotic plaque (4.0, 19.0, 35.3, 53.5% or 3.5, 16.8, 43.7, 55.9%, or 6.6, 7.6, 9.8, 20.0%) and albuminuria (7.9, 8.7, 11.4, 20.6% or 7.9, 8.2, 16.6, 19.5% or 6.6, 7.6, 9.8, 20.0%) increased, all P<0.001.CEP was associated with albuminuria in individuals aged 61 or 71 years, with moderate or very high SCORE or intermediate or high FRS (all P<0.05), with atherosclerotic plaques in individuals aged 41, 51 or 61 years, with moderate SCORE or with high-intermediate or high FRS (all P<0.01), and with cfPWV at least 12m/s in individuals aged 51 years (P<0.001) or high FRS (P<0.05). Presence of at least one SVD was significantly associated with an increased risk in individuals aged 51 [hazard ratio 2.7 (1.6-4.8)] and 61 years [hazard ratio 2.7 (1.5-4.7)], moderate [hazard ratio 2.4 (1.6-3.7)] or high SCORE risk group [hazard ratio 2.3 (1.2-4.7)] and low-intermediate [hazard ratio 3.3 (1.5-7.0)], high-intermediate [hazard ratio 2.3 (1.5-3.5)] and high FRS risk group [hazard ratio 2.0 (1.4-3.0)]. CONCLUSION: SVD and especially atherosclerotic plaques or urine albumin/creatinine ratio (UACR) at least 0.73/1.06mg/mmol (men/women) added prognostic information in individuals aged 51 or 61 years or with moderate or intermediate risk.

KW - Age Factors

KW - Albuminuria

KW - Atherosclerosis

KW - Humans

KW - Prognosis

KW - Pulse Wave Analysis

KW - Risk Factors

U2 - 10.1097/hjh.0000000000000147

DO - 10.1097/hjh.0000000000000147

M3 - Journal article

C2 - 24621803

SN - 0263-6352

VL - 32

SP - 1034

EP - 1041

JO - Journal of Hypertension

JF - Journal of Hypertension

IS - 5

ER -

Association between albuminuria, atherosclerotic plaques, elevated pulse wave velocity, age, risk category and prognosis in apparently healthy individuals

Abstract

Keywords

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