Assessment of maximal fat oxidation during exercise: A systematic review

Francisco J. Amaro-Gahete; Guillermo Sanchez-Delgado; Lucas Jurado-Fasoli; Alejandro De-la-O; Manuel J. Castillo; Jorn W. Helge; Jonatan R. Ruiz

doi:10.1111/sms.13424

Assessment of maximal fat oxidation during exercise: A systematic review

Francisco J. Amaro-Gahete, Guillermo Sanchez-Delgado, Lucas Jurado-Fasoli, Alejandro De-la-O, Manuel J. Castillo, Jorn W. Helge, Jonatan R. Ruiz

18 Citations (Scopus)

Abstract

Maximal fat oxidation during exercise (MFO) and the exercise intensity eliciting MFO (Fat(max)) are considered biological markers of metabolic health and performance. A wide range of studies have been performed to increase our knowledge about their regulation by exercise and/or nutritional intervention. However, numerous data collection and analysis approaches have been applied, which may have affected the MFO and Fat(max) estimation. We aimed to systematically review the available studies describing and/or comparing different data collection and analysis approach factors that could affect MFO and Fat(max) estimation in healthy individuals and patients. Two independent researchers performed the search. We included all original studies in which MFO and/or Fat(max) were estimated by indirect calorimetry through an incremental graded exercise protocol published from 2002 to 2019. This systematic review provides key information about the factors that could affect MFO and Fat(max) estimation: ergometer type, metabolic cart used, warm-up duration and intensity, stage duration and intensities imposed in the graded exercise protocol, time interval selected for data analysis, stoichiometric equation selected to estimate fat oxidation, data analysis approach, time of the day when the test was performed, fasting time/previous meal before the test, and testing days for MFO/Fat(max) and maximal oxygen uptake assessment. We suggest that researchers measuring MFO and Fat(max) should take into account these key methodological issues that can considerably affect the accuracy, validity, and reliability of the measurement. Likewise, when comparing different studies, it is important to check whether the above-mentioned key methodological issues are similar in such studies to avoid ambiguous and unacceptable comparisons.

Original language	English
Journal	Scandinavian Journal of Medicine & Science in Sports
Volume	29
Issue number	7
Pages (from-to)	910-921
ISSN	0905-7188
DOIs	https://doi.org/10.1111/sms.13424
Publication status	Published - Jul 2019

Keywords

exercise
Fat(max)
fuel oxidation
indirect calorimetry
methodology
MFO
peak fat oxidation

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10.1111/sms.13424

Cite this

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title = "Assessment of maximal fat oxidation during exercise: A systematic review",

abstract = "Maximal fat oxidation during exercise (MFO) and the exercise intensity eliciting MFO (Fat(max)) are considered biological markers of metabolic health and performance. A wide range of studies have been performed to increase our knowledge about their regulation by exercise and/or nutritional intervention. However, numerous data collection and analysis approaches have been applied, which may have affected the MFO and Fat(max) estimation. We aimed to systematically review the available studies describing and/or comparing different data collection and analysis approach factors that could affect MFO and Fat(max) estimation in healthy individuals and patients. Two independent researchers performed the search. We included all original studies in which MFO and/or Fat(max) were estimated by indirect calorimetry through an incremental graded exercise protocol published from 2002 to 2019. This systematic review provides key information about the factors that could affect MFO and Fat(max) estimation: ergometer type, metabolic cart used, warm-up duration and intensity, stage duration and intensities imposed in the graded exercise protocol, time interval selected for data analysis, stoichiometric equation selected to estimate fat oxidation, data analysis approach, time of the day when the test was performed, fasting time/previous meal before the test, and testing days for MFO/Fat(max) and maximal oxygen uptake assessment. We suggest that researchers measuring MFO and Fat(max) should take into account these key methodological issues that can considerably affect the accuracy, validity, and reliability of the measurement. Likewise, when comparing different studies, it is important to check whether the above-mentioned key methodological issues are similar in such studies to avoid ambiguous and unacceptable comparisons.",

keywords = "exercise, Fat(max), fuel oxidation, indirect calorimetry, methodology, MFO, peak fat oxidation",

author = "Amaro-Gahete, {Francisco J.} and Guillermo Sanchez-Delgado and Lucas Jurado-Fasoli and Alejandro De-la-O and Castillo, {Manuel J.} and Helge, {Jorn W.} and Ruiz, {Jonatan R.}",

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AU - Sanchez-Delgado, Guillermo

AU - Jurado-Fasoli, Lucas

AU - De-la-O, Alejandro

AU - Castillo, Manuel J.

AU - Helge, Jorn W.

AU - Ruiz, Jonatan R.

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N2 - Maximal fat oxidation during exercise (MFO) and the exercise intensity eliciting MFO (Fat(max)) are considered biological markers of metabolic health and performance. A wide range of studies have been performed to increase our knowledge about their regulation by exercise and/or nutritional intervention. However, numerous data collection and analysis approaches have been applied, which may have affected the MFO and Fat(max) estimation. We aimed to systematically review the available studies describing and/or comparing different data collection and analysis approach factors that could affect MFO and Fat(max) estimation in healthy individuals and patients. Two independent researchers performed the search. We included all original studies in which MFO and/or Fat(max) were estimated by indirect calorimetry through an incremental graded exercise protocol published from 2002 to 2019. This systematic review provides key information about the factors that could affect MFO and Fat(max) estimation: ergometer type, metabolic cart used, warm-up duration and intensity, stage duration and intensities imposed in the graded exercise protocol, time interval selected for data analysis, stoichiometric equation selected to estimate fat oxidation, data analysis approach, time of the day when the test was performed, fasting time/previous meal before the test, and testing days for MFO/Fat(max) and maximal oxygen uptake assessment. We suggest that researchers measuring MFO and Fat(max) should take into account these key methodological issues that can considerably affect the accuracy, validity, and reliability of the measurement. Likewise, when comparing different studies, it is important to check whether the above-mentioned key methodological issues are similar in such studies to avoid ambiguous and unacceptable comparisons.

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