Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

Eva Rye Rasmussen; Christian von Buchwald; Mia Wadelius; Sumangali Chandra Prasad; Shailajah Kamaleswaran; Kawa Khaled Ajgeiy; Georg Authried; Kristine Appel U Pallesen; Anette Bygum

doi:10.1155/2017/1476402

Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

Eva Rye Rasmussen, Christian von Buchwald, Mia Wadelius, Sumangali Chandra Prasad, Shailajah Kamaleswaran, Kawa Khaled Ajgeiy, Georg Authried, Kristine Appel U Pallesen, Anette Bygum

Department of Clinical Medicine

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Abstract

Objective. To asses a cohort of 105 consecutive patients with angiotensin converting enzyme-inhibitor induced angioedema with regard to demographics, risk factors, family history of angioedema, hospitalization, airway management, outcome, and use of diagnostic codes used for the condition. Study Design. Cohort study. Methods. This was a retrospective cohort study of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema in the period 1995-2014. Results. The cohort consisted of 67 females and 38 males (F : M ratio 1.8), with a mean age of 63 [range 26-86] years. Female gender was associated with a significantly higher risk of angiotensin converting enzyme-inhibitor induced angioedema. 6.7% had a positive family history of angioedema. Diabetes seemed to be a protective factor with regard to angioedema. 95% experienced angioedema of the head and neck. 4.7% needed intubation or tracheostomy. 74 admissions took place during the study period with a total of 143 days spent in the hospital. The diagnosis codes most often used for this condition were "DT783 Quincke's oedema" and "DT78.4 Allergy unspecified". Complement C1 inhibitor was normal in all tested patients. Conclusion. Female gender predisposes to angiotensin converting enzyme-inhibitor induced angioedema, whereas diabetes seems to be a protective factor.

Original language	English
Article number	1476402
Journal	International Journal of Otolaryngology
Volume	2017
Number of pages	7
ISSN	1687-9201
DOIs	https://doi.org/10.1155/2017/1476402
Publication status	Published - 2017

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Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced AngioedemaFinal published version, 1.24 MBLicence: CC BY

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title = "Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema",

abstract = "Objective. To asses a cohort of 105 consecutive patients with angiotensin converting enzyme-inhibitor induced angioedema with regard to demographics, risk factors, family history of angioedema, hospitalization, airway management, outcome, and use of diagnostic codes used for the condition. Study Design. Cohort study. Methods. This was a retrospective cohort study of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema in the period 1995-2014. Results. The cohort consisted of 67 females and 38 males (F : M ratio 1.8), with a mean age of 63 [range 26-86] years. Female gender was associated with a significantly higher risk of angiotensin converting enzyme-inhibitor induced angioedema. 6.7% had a positive family history of angioedema. Diabetes seemed to be a protective factor with regard to angioedema. 95% experienced angioedema of the head and neck. 4.7% needed intubation or tracheostomy. 74 admissions took place during the study period with a total of 143 days spent in the hospital. The diagnosis codes most often used for this condition were {"}DT783 Quincke's oedema{"} and {"}DT78.4 Allergy unspecified{"}. Complement C1 inhibitor was normal in all tested patients. Conclusion. Female gender predisposes to angiotensin converting enzyme-inhibitor induced angioedema, whereas diabetes seems to be a protective factor.",

author = "Rasmussen, {Eva Rye} and {von Buchwald}, Christian and Mia Wadelius and Prasad, {Sumangali Chandra} and Shailajah Kamaleswaran and Ajgeiy, {Kawa Khaled} and Georg Authried and Pallesen, {Kristine Appel U} and Anette Bygum",

year = "2017",

doi = "10.1155/2017/1476402",

language = "English",

volume = "2017",

journal = "International Journal of Otolaryngology",

issn = "1687-9201",

publisher = "Hindawi Publishing Corporation",

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T1 - Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

AU - Rasmussen, Eva Rye

AU - von Buchwald, Christian

AU - Wadelius, Mia

AU - Prasad, Sumangali Chandra

AU - Kamaleswaran, Shailajah

AU - Ajgeiy, Kawa Khaled

AU - Authried, Georg

AU - Pallesen, Kristine Appel U

AU - Bygum, Anette

PY - 2017

Y1 - 2017

N2 - Objective. To asses a cohort of 105 consecutive patients with angiotensin converting enzyme-inhibitor induced angioedema with regard to demographics, risk factors, family history of angioedema, hospitalization, airway management, outcome, and use of diagnostic codes used for the condition. Study Design. Cohort study. Methods. This was a retrospective cohort study of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema in the period 1995-2014. Results. The cohort consisted of 67 females and 38 males (F : M ratio 1.8), with a mean age of 63 [range 26-86] years. Female gender was associated with a significantly higher risk of angiotensin converting enzyme-inhibitor induced angioedema. 6.7% had a positive family history of angioedema. Diabetes seemed to be a protective factor with regard to angioedema. 95% experienced angioedema of the head and neck. 4.7% needed intubation or tracheostomy. 74 admissions took place during the study period with a total of 143 days spent in the hospital. The diagnosis codes most often used for this condition were "DT783 Quincke's oedema" and "DT78.4 Allergy unspecified". Complement C1 inhibitor was normal in all tested patients. Conclusion. Female gender predisposes to angiotensin converting enzyme-inhibitor induced angioedema, whereas diabetes seems to be a protective factor.

AB - Objective. To asses a cohort of 105 consecutive patients with angiotensin converting enzyme-inhibitor induced angioedema with regard to demographics, risk factors, family history of angioedema, hospitalization, airway management, outcome, and use of diagnostic codes used for the condition. Study Design. Cohort study. Methods. This was a retrospective cohort study of 105 patients with angiotensin converting enzyme-inhibitor induced angioedema in the period 1995-2014. Results. The cohort consisted of 67 females and 38 males (F : M ratio 1.8), with a mean age of 63 [range 26-86] years. Female gender was associated with a significantly higher risk of angiotensin converting enzyme-inhibitor induced angioedema. 6.7% had a positive family history of angioedema. Diabetes seemed to be a protective factor with regard to angioedema. 95% experienced angioedema of the head and neck. 4.7% needed intubation or tracheostomy. 74 admissions took place during the study period with a total of 143 days spent in the hospital. The diagnosis codes most often used for this condition were "DT783 Quincke's oedema" and "DT78.4 Allergy unspecified". Complement C1 inhibitor was normal in all tested patients. Conclusion. Female gender predisposes to angiotensin converting enzyme-inhibitor induced angioedema, whereas diabetes seems to be a protective factor.

U2 - 10.1155/2017/1476402

DO - 10.1155/2017/1476402

M3 - Journal article

C2 - 28286522

SN - 1687-9201

VL - 2017

JO - International Journal of Otolaryngology

JF - International Journal of Otolaryngology

M1 - 1476402

ER -

Assessment of 105 Patients with Angiotensin Converting Enzyme-Inhibitor Induced Angioedema

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