Abstract
The proposal that Kaposi's sarcoma undergoes cellular transformation from early to late stages was studied with argyrophilic nucleolar organizer regions, proliferating cell nuclear antigen/cyclin, and immunoperoxidase staining for factor VIII-related antigen. Staining of argyrophilic nucleolar organizer regions was significantly increased in the plaque/nodular stage compared to the patch stage. The endothelial-selective marker factor VIII-related antigen stained more intensely in patch stage lesions. This was inversely correlated with staining of argyrophilic nucleolar organizer regions. Proliferating cell nuclear antigen/cyclin staining did not correlate with tumor stage or with factor VIII-related antigen. The changes in argyrophilic nucleolar organizer regions and factor VIII-related antigen staining are evidence for cellular transformation in Kaposi's sarcoma.
| Original language | English |
|---|---|
| Journal | Archives of Pathology & Laboratory Medicine |
| Volume | 119 |
| Issue number | 6 |
| Pages (from-to) | 538-41 |
| Number of pages | 3 |
| ISSN | 0003-9985 |
| Publication status | Published - 1995 |
| Externally published | Yes |