TY - JOUR
T1 - Are TMEM genes potential candidate genes for panic disorder?
AU - NO, Gregersen
AU - Buttenschøn, Henriette Nørmølle
AU - Hedemand, Anne
AU - Dahl, Hans Atli
AU - Kristensen, Ann Suhl
AU - B, Clementsen
AU - Woldbye, David Paul Drucker
AU - Koefoed, Pernille
AU - Erhardt, A
AU - Kruse, T A
AU - Wang, August Gabriel
AU - Børglum, Anders
AU - Mors, Ole
PY - 2014
Y1 - 2014
N2 - We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.
AB - We analysed single nucleotide polymorphisms in two transmembrane genes (TMEM98 and TMEM132E) in panic disorder (PD) patients and control individuals from the Faroe Islands, Denmark and Germany. The genes encode single-pass membrane proteins and are located within chromosome 17q11.2-q12, a previously reported candidate region for PD. Three single nucleotide polymorphisms (rs887231, rs887230 and rs4795942) located upstream and within TMEM132E showed a nominal significant association with PD primarily in the Danish cohort. No nominal significant associations were observed between TMEM98 and PD. Our data indicate that TMEM132E might contribute moderately towards the risk of developing PD.
U2 - 10.1097/ypg.0000000000000022
DO - 10.1097/ypg.0000000000000022
M3 - Journal article
C2 - 24362369
SN - 0955-8829
VL - 24
SP - 37
EP - 41
JO - Psychiatric Genetics
JF - Psychiatric Genetics
IS - 1
ER -