Are basophil histamine release and high affinity IgE receptor expression involved in asymptomatic skin sensitization?

TY - JOUR

T1 - Are basophil histamine release and high affinity IgE receptor expression involved in asymptomatic skin sensitization?

AU - Jensen, Bettina Margrethe

AU - Assing, K

AU - Jensen, Lone Hummelshøj

AU - Glue, C

AU - Skov, P S

AU - Poulsen, L K

PY - 2006

Y1 - 2006

N2 - Immunoglobulin (Ig)E-sensitized persons with positive skin prick test, but no allergy symptoms, are classified as being asymptomatic skin sensitized (AS). The allergic type 1 disease is dependant on IgE binding to the high affinity IgE-receptor (FcepsilonRI) expressed on basophils and mast cells. However, a relationship between the AS status and FcepsilonRI has not been investigated. We aimed to characterize basophils from AS by looking at histamine release (HR) (sensitivity and reactivity) and the FcepsilonRI molecule, and compare it with nonatopic (NA) or allergic (A) persons.

AB - Immunoglobulin (Ig)E-sensitized persons with positive skin prick test, but no allergy symptoms, are classified as being asymptomatic skin sensitized (AS). The allergic type 1 disease is dependant on IgE binding to the high affinity IgE-receptor (FcepsilonRI) expressed on basophils and mast cells. However, a relationship between the AS status and FcepsilonRI has not been investigated. We aimed to characterize basophils from AS by looking at histamine release (HR) (sensitivity and reactivity) and the FcepsilonRI molecule, and compare it with nonatopic (NA) or allergic (A) persons.

U2 - http://dx.doi.org/10.1111/j.1398-9995.2006.00991.x

DO - http://dx.doi.org/10.1111/j.1398-9995.2006.00991.x

M3 - Journal article

SN - 0105-4538

VL - 61

SP - 303

EP - 310

JO - Allergy: European Journal of Allergy and Clinical Immunology

JF - Allergy: European Journal of Allergy and Clinical Immunology

IS - 3

ER -