Abstract
Conduction processes in the vasculature have traditionally been described using cable theory, i.e., locally induced signals decaying passively along the arteriolar wall. The decay is typically quantified using the steady-state length-constant, λ, derived from cable theory. However, the applicability of cable theory to blood vessels depends on assumptions that are not necessarily fulfilled in small arteries and arterioles. We have employed a morphologically and electrophysiologically detailed mathematical model of a rat mesenteric arteriole to investigate if the assumptions hold and whether λ adequately describes simulated conduction profiles. We find that several important cable theory assumptions are violated when applied to small blood vessels. However, the phenomenological use of a length-constant from a single exponential function is a good measure of conduction length. Hence, λ should be interpreted as a descriptive measure and not in light of cable theory. Determination of λ using cable theory assumes steady-state conditions. In contrast, using the model it is possible to probe how conduction behaves before steady state is achieved. As ion channels have time-dependent activation and inactivation, the conduction profile changes considerably during this dynamic period with an initially longer spread of current. This may have implications in relation to explaining why different agonists have different conduction properties. Also, it illustrates the necessity of using and developing models that handle the nonlinearity of ion channels.
| Original language | English |
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| Publication date | 21 Mar 2012 |
| Number of pages | 1 |
| Publication status | Published - 21 Mar 2012 |
| Event | Experimental Biology 2012 - San Diego, United States Duration: 21 Apr 2012 → 25 Apr 2012 |
Conference
| Conference | Experimental Biology 2012 |
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| Country/Territory | United States |
| City | San Diego |
| Period | 21/04/2012 → 25/04/2012 |