Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study

Line Cleemann; Kristian H Mortensen; Kirsten Holm; Heidi Smedegaard; Sven O Skouby; Steen B Wieslander; Anne-Mette Leffers; Per Leth-Espensen; Erik Morre Pedersen; Claus H Gravholt; Line Cleemann; Kristian Havmand Mortensen; Kirsten Holm; Heidi Smedegaard; Sven Olaf Skouby; Steen B Wieslander; Anne Mette Leffers; Per Leth-Espensen; Erik Morre Pedersen; Claus H Gravholt

doi:10.1007/s00246-009-9626-8

Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study

Line Cleemann, Kristian H Mortensen, Kirsten Holm, Heidi Smedegaard, Sven O Skouby, Steen B Wieslander, Anne-Mette Leffers, Per Leth-Espensen, Erik Morre Pedersen, Claus H Gravholt, Line Cleemann, Kristian Havmand Mortensen, Kirsten Holm, Heidi Smedegaard, Sven Olaf Skouby, Steen B Wieslander, Anne Mette Leffers, Per Leth-Espensen, Erik Morre Pedersen, Claus H Gravholt

41 Citations (Scopus)

Abstract

This study aimed to determine the dimensions of the thoracic aorta and the predictors of aortic dimensions in girls and young women with Turner syndrome (TS). A cross-sectional study was performed at a secondary care center. The study compared 41 TS patients with 50 healthy age-matched control subjects. The mean age of the patients was 17 ± 3.3 years. Magnetic resonance imaging was performed for all the patients. The thoracic aortic diameters of the patients were measured at nine positions. Adjustment for body surface area (BSA) was performed. The outcome for the patients was measured in terms of absolute and BSA-adjusted aortic dilation. In TS, both the absolute and the BSA-adjusted mean aortic diameters were smaller than or comparable with those of the control subjects. However, individual aortic dilation at one to four positions was found in four TS patients according to the uncorrected data and in five TS patients after BSA-adjustment. The aortic diameters correlated with height, weight, body mass index (BMI), and BSA at all positions (R = 0.34-0.60; all p<0.04). The diameters of the aortic arch and the descending aorta correlated with a history of aortic coarctation (R = 0.35-0.52; p<0.03). The presence of bicuspid aortic valves correlated at the descending part of the aorta (R = 0.38; p<0.03). The mean thoracic aortic dimensions were not enlarged in girls or young TS patients. The BSA predicted aortic size at all positions. The prevalence of aortic dilation and aneurysm was lower in this population of girls and younger women with TS than in older TS populations.

Original language	English
Journal	Pediatric Cardiology
Volume	31
Issue number	4
Pages (from-to)	497-504
Number of pages	8
ISSN	0172-0643
DOIs	https://doi.org/10.1007/s00246-009-9626-8
Publication status	Published - 1 May 2010

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Cleemann, L., Mortensen, K. H., Holm, K., Smedegaard, H., Skouby, S. O., Wieslander, S. B., Leffers, A-M., Leth-Espensen, P., Pedersen, E. M., Gravholt, C. H., Cleemann, L., Mortensen, K. H., Holm, K., Smedegaard, H., Skouby, S. O., Wieslander, S. B., Leffers, A. M., Leth-Espensen, P., Pedersen, E. M., & Gravholt, C. H. (2010). Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study. Pediatric Cardiology, 31(4), 497-504. https://doi.org/10.1007/s00246-009-9626-8

Cleemann, L, Mortensen, KH, Holm, K, Smedegaard, H, Skouby, SO, Wieslander, SB, Leffers, A-M, Leth-Espensen, P, Pedersen, EM, Gravholt, CH, Cleemann, L, Mortensen, KH, Holm, K, Smedegaard, H, Skouby, SO, Wieslander, SB, Leffers, AM, Leth-Espensen, P, Pedersen, EM & Gravholt, CH 2010, 'Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study', Pediatric Cardiology, vol. 31, no. 4, pp. 497-504. https://doi.org/10.1007/s00246-009-9626-8

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title = "Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study",

abstract = "This study aimed to determine the dimensions of the thoracic aorta and the predictors of aortic dimensions in girls and young women with Turner syndrome (TS). A cross-sectional study was performed at a secondary care center. The study compared 41 TS patients with 50 healthy age-matched control subjects. The mean age of the patients was 17 ± 3.3 years. Magnetic resonance imaging was performed for all the patients. The thoracic aortic diameters of the patients were measured at nine positions. Adjustment for body surface area (BSA) was performed. The outcome for the patients was measured in terms of absolute and BSA-adjusted aortic dilation. In TS, both the absolute and the BSA-adjusted mean aortic diameters were smaller than or comparable with those of the control subjects. However, individual aortic dilation at one to four positions was found in four TS patients according to the uncorrected data and in five TS patients after BSA-adjustment. The aortic diameters correlated with height, weight, body mass index (BMI), and BSA at all positions (R = 0.34-0.60; all p<0.04). The diameters of the aortic arch and the descending aorta correlated with a history of aortic coarctation (R = 0.35-0.52; p<0.03). The presence of bicuspid aortic valves correlated at the descending part of the aorta (R = 0.38; p<0.03). The mean thoracic aortic dimensions were not enlarged in girls or young TS patients. The BSA predicted aortic size at all positions. The prevalence of aortic dilation and aneurysm was lower in this population of girls and younger women with TS than in older TS populations.",

author = "Line Cleemann and Mortensen, {Kristian H} and Kirsten Holm and Heidi Smedegaard and Skouby, {Sven O} and Wieslander, {Steen B} and Anne-Mette Leffers and Per Leth-Espensen and Pedersen, {Erik Morre} and Gravholt, {Claus H} and Line Cleemann and Mortensen, {Kristian Havmand} and Kirsten Holm and Heidi Smedegaard and Skouby, {Sven Olaf} and Wieslander, {Steen B} and Leffers, {Anne Mette} and Per Leth-Espensen and Pedersen, {Erik Morre} and Gravholt, {Claus H}",

note = "Keywords: Adolescent; Age Factors; Aorta, Thoracic; Aortic Coarctation; Aortic Valve; Aortography; Body Height; Body Mass Index; Body Surface Area; Body Weight; Child; Cross-Sectional Studies; Dilatation, Pathologic; Female; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Organ Size; Reference Values; Turner Syndrome; Young Adult",

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doi = "10.1007/s00246-009-9626-8",

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pages = "497--504",

journal = "Pediatric Cardiology",

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T1 - Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study

AU - Cleemann, Line

AU - Mortensen, Kristian H

AU - Holm, Kirsten

AU - Smedegaard, Heidi

AU - Skouby, Sven O

AU - Wieslander, Steen B

AU - Leffers, Anne-Mette

AU - Leth-Espensen, Per

AU - Pedersen, Erik Morre

AU - Gravholt, Claus H

AU - Cleemann, Line

AU - Mortensen, Kristian Havmand

AU - Holm, Kirsten

AU - Smedegaard, Heidi

AU - Skouby, Sven Olaf

AU - Wieslander, Steen B

AU - Leffers, Anne Mette

AU - Leth-Espensen, Per

AU - Pedersen, Erik Morre

AU - Gravholt, Claus H

N1 - Keywords: Adolescent; Age Factors; Aorta, Thoracic; Aortic Coarctation; Aortic Valve; Aortography; Body Height; Body Mass Index; Body Surface Area; Body Weight; Child; Cross-Sectional Studies; Dilatation, Pathologic; Female; Humans; Image Processing, Computer-Assisted; Imaging, Three-Dimensional; Magnetic Resonance Angiography; Magnetic Resonance Imaging; Organ Size; Reference Values; Turner Syndrome; Young Adult

PY - 2010/5/1

Y1 - 2010/5/1

N2 - This study aimed to determine the dimensions of the thoracic aorta and the predictors of aortic dimensions in girls and young women with Turner syndrome (TS). A cross-sectional study was performed at a secondary care center. The study compared 41 TS patients with 50 healthy age-matched control subjects. The mean age of the patients was 17 ± 3.3 years. Magnetic resonance imaging was performed for all the patients. The thoracic aortic diameters of the patients were measured at nine positions. Adjustment for body surface area (BSA) was performed. The outcome for the patients was measured in terms of absolute and BSA-adjusted aortic dilation. In TS, both the absolute and the BSA-adjusted mean aortic diameters were smaller than or comparable with those of the control subjects. However, individual aortic dilation at one to four positions was found in four TS patients according to the uncorrected data and in five TS patients after BSA-adjustment. The aortic diameters correlated with height, weight, body mass index (BMI), and BSA at all positions (R = 0.34-0.60; all p<0.04). The diameters of the aortic arch and the descending aorta correlated with a history of aortic coarctation (R = 0.35-0.52; p<0.03). The presence of bicuspid aortic valves correlated at the descending part of the aorta (R = 0.38; p<0.03). The mean thoracic aortic dimensions were not enlarged in girls or young TS patients. The BSA predicted aortic size at all positions. The prevalence of aortic dilation and aneurysm was lower in this population of girls and younger women with TS than in older TS populations.

AB - This study aimed to determine the dimensions of the thoracic aorta and the predictors of aortic dimensions in girls and young women with Turner syndrome (TS). A cross-sectional study was performed at a secondary care center. The study compared 41 TS patients with 50 healthy age-matched control subjects. The mean age of the patients was 17 ± 3.3 years. Magnetic resonance imaging was performed for all the patients. The thoracic aortic diameters of the patients were measured at nine positions. Adjustment for body surface area (BSA) was performed. The outcome for the patients was measured in terms of absolute and BSA-adjusted aortic dilation. In TS, both the absolute and the BSA-adjusted mean aortic diameters were smaller than or comparable with those of the control subjects. However, individual aortic dilation at one to four positions was found in four TS patients according to the uncorrected data and in five TS patients after BSA-adjustment. The aortic diameters correlated with height, weight, body mass index (BMI), and BSA at all positions (R = 0.34-0.60; all p<0.04). The diameters of the aortic arch and the descending aorta correlated with a history of aortic coarctation (R = 0.35-0.52; p<0.03). The presence of bicuspid aortic valves correlated at the descending part of the aorta (R = 0.38; p<0.03). The mean thoracic aortic dimensions were not enlarged in girls or young TS patients. The BSA predicted aortic size at all positions. The prevalence of aortic dilation and aneurysm was lower in this population of girls and younger women with TS than in older TS populations.

U2 - 10.1007/s00246-009-9626-8

DO - 10.1007/s00246-009-9626-8

M3 - Journal article

C2 - 20063160

SN - 0172-0643

VL - 31

SP - 497

EP - 504

JO - Pediatric Cardiology

JF - Pediatric Cardiology

IS - 4

ER -

Aortic dimensions in girls and young women with turner syndrome: a magnetic resonance imaging study

Abstract

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