Abstract
Novel remedies in the battle against multidrug-resistant bacterial strains are urgently needed, and one obvious approach involves antimicrobial peptides and mimics hereof. The impact of α- and β-peptoid as well as β3-amino acid modifications on the activity profile against β-lactamase-producing Escherichia coli was assessed by testing an array comprising different types of cationic peptidomimetics obtained by a general monomer-based solid-phase synthesis protocol. Most of the peptidomimetics possessed high to moderate activity toward multidrug-resistant E. coli as opposed to the corresponding inactive peptides. Nevertheless, differences in hemolytic activities indicate that a careful choice of backbone design constitutes a significant parameter in the search for effective cationic antimicrobial peptidomimetics targeting specific bacteria.
| Original language | English |
|---|---|
| Journal | Journal of Medicinal Chemistry |
| Volume | 55 |
| Issue number | 16 |
| Pages (from-to) | 7253-61 |
| Number of pages | 9 |
| ISSN | 0022-2623 |
| DOIs | |
| Publication status | Published - 23 Aug 2012 |