Abstract
Human immunodeficiency virus (HIV)-infected individuals are at increased risk of invasive pneumococcal disease (IPD). In order to assess the immunogenicity of pneumococcal proteins and polysaccharide, we investigated protein and serotype-specific antibody responses after HIV-associated IPD. Methods. Specific antipneumococcal immunoglobulin G to 27 pneumococcal protein antigens and 30 serotype polysaccharides was measured in plasma before and after IPD in HIV-infected individuals and compared to HIVinfected individuals without IPD. Results. Over time, 81% of IPD cases responded to at least 1 protein compared to 51% of non-IPD controls. HIV IPD cases responded to more proteins than non-IPD controls (8.6 ± 8.4 vs 4.2 ± 7.6 proteins; P = .01), and had a significantly higher probability of yielding an antibody response to the proteins PiaA, PsaA, and PcpA. Twentytwo percent of HIV-infected individuals with IPD had a serotype-specific antibody response. Younger age at the time of IPD was the only predictor of a serotype-specific pneumococcal antibody response, whereas we did not identify predictors of a protein-specific antibody response. Conclusions. Antibody responses occurred more frequently to pneumococcal proteins than to polysaccharide, and protein antibodies persisted for longer than polysaccharide-specific antibodies. PcpA, PiaA, and PsaA were the most immunogenic proteins.
| Original language | English |
|---|---|
| Journal | The Journal of Infectious Diseases |
| Volume | 212 |
| Issue number | 7 |
| Pages (from-to) | 1093-9 |
| Number of pages | 7 |
| ISSN | 0022-1899 |
| DOIs | |
| Publication status | Published - 1 Oct 2015 |
Keywords
- Adhesins, Bacterial
- Adult
- Antibodies, Bacterial
- Antiretroviral Therapy, Highly Active
- Bacterial Proteins
- Carrier Proteins
- Female
- HIV Infections
- Humans
- Immunoglobulin G
- Lipoproteins
- Male
- Middle Aged
- Pneumococcal Infections
- Polysaccharides
- Serogroup
- Streptococcus pneumoniae
