Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children

Regis W Tiendrebeogo; Bright Adu; Susheel K Singh; Morten H Dziegiel; Issa Nébié; Sodiomon B Sirima; Michael Christiansen; Daniel Dodoo; Michael Theisen

doi:10.1093/ofid/ofv044

Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children

Regis W Tiendrebeogo, Bright Adu, Susheel K Singh, Morten H Dziegiel, Issa Nébié, Sodiomon B Sirima, Michael Christiansen, Daniel Dodoo, Michael Theisen

26 Citations (Scopus)

Abstract

The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

Original language	English
Article number	ofv044
Journal	Open forum in Infectious Diseases
Volume	2
Issue number	2
Number of pages	5
ISSN	2328-8957
DOIs	https://doi.org/10.1093/ofid/ofv044
Publication status	Published - 1 Apr 2015

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Tiendrebeogo, R. W., Adu, B., Singh, S. K., Dziegiel, M. H., Nébié, I., Sirima, S. B., Christiansen, M., Dodoo, D., & Theisen, M. (2015). Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children. Open forum in Infectious Diseases, 2(2), Article ofv044. https://doi.org/10.1093/ofid/ofv044

Tiendrebeogo, RW, Adu, B, Singh, SK , Dziegiel, MH, Nébié, I, Sirima, SB, Christiansen, M, Dodoo, D & Theisen, M 2015, 'Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children', Open forum in Infectious Diseases, vol. 2, no. 2, ofv044. https://doi.org/10.1093/ofid/ofv044

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abstract = "The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.",

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AU - Dziegiel, Morten H

AU - Nébié, Issa

AU - Sirima, Sodiomon B

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AU - Dodoo, Daniel

AU - Theisen, Michael

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AB - The antibody-dependent respiratory burst and opsonic phagocytosis assays have been associated with protection against malaria; however, other mechanisms may also be involved. The antibody-dependent cellular inhibition (ADCI) assay is yet to be correlated with protection in longitudinal cohort studies (LCS). We investigated the relationship between ADCI activity of immunoglobulin G before malaria season and risk of malaria in a LCS involving Ghanaian children. High ADCI activity was significantly associated with reduced risk against malaria. Findings here suggest a potential usefulness of the ADCI assay as a correlate of protection to guide malaria vaccine studies.

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Antibody-dependent cellular inhibition is associated with reduced risk against febrile malaria in a longitudinal cohort study involving Ghanaian children

Abstract

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