Diarra, A., Nebie, I., Tiono, A., Soulama, I., Ouedraogo, A., Konate, A., Theisen, M., Dodoo, D., Traore, A., & Sirima, S. B. (2012). Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso. Malaria Journal, 11(1), 79. https://doi.org/10.1186/1475-2875-11-79
Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso. / Diarra, Amidou; Nebie, Issa; Tiono, Alfred et al.
In:
Malaria Journal, Vol. 11, No. 1, 2012, p. 79.
Research output: Contribution to journal › Journal article › Research › peer-review
Diarra, A, Nebie, I, Tiono, A, Soulama, I, Ouedraogo, A, Konate, A, Theisen, M, Dodoo, D, Traore, A & Sirima, SB 2012, 'Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso', Malaria Journal, vol. 11, no. 1, pp. 79. https://doi.org/10.1186/1475-2875-11-79
Diarra A, Nebie I, Tiono A, Soulama I, Ouedraogo A, Konate A et al. Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso. Malaria Journal. 2012;11(1):79. doi: 10.1186/1475-2875-11-79
Diarra, Amidou ; Nebie, Issa ; Tiono, Alfred et al. / Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso. In: Malaria Journal. 2012 ; Vol. 11, No. 1. pp. 79.
@article{f95ac7a03d9841de87f3ee89a7239dd0,
title = "Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso",
abstract = "Background: Patient immune status is thought to affect the efficacy of anti-malarial chemotherapy. This is a subject of some importance, since evidence of immunity-related interactions may influence our use of chemotherapy in populations with drug resistance, as well as assessment of the value of suboptimal vaccines. The study aim was to investigate relationship between antibodies and anti-malarial drug treatment outcomes. Methods. Some 248 children aged 0.5 and 15 years were recruited prior to the high malaria transmission season. Venous blood (5 ml) was obtained from each child to measure antibody levels to selected malaria antigens, using ELISA. Blood smears were also performed to assess drug efficacy and malaria infection prevalence. Children were actively followed up to record clinical malaria cases. Results: IgG levels to MSP3 were always higher in the successfully treated group than in the group with treatment failure. The same observation was made for GLURP but the reverse observation was noticed for MSP1-19. Cytophilic and non-cytophilic antibodies were significantly associated with protection against all three antigens, except for IgG4 to MSP1-19 and GLURP. Conclusion: Acquired anti-malarial antibodies may play an important role in the efficacy of anti-malarial drugs in younger children more susceptible to the disease.",
author = "Amidou Diarra and Issa Nebie and Alfred Tiono and Issiaka Soulama and Alphonse Ouedraogo and Amadou Konate and Michael Theisen and Daniel Dodoo and Alfred Traore and Sirima, {Sodiomon B}",
year = "2012",
doi = "10.1186/1475-2875-11-79",
language = "English",
volume = "11",
pages = "79",
journal = "Malaria Journal",
issn = "1475-2875",
publisher = "BioMed Central",
number = "1",
}
TY - JOUR
T1 - Antibodies to malaria vaccine candidates are associated with chloroquine or sulphadoxine/pyrimethamine treatment efficacy in children in an endemic area of Burkina Faso
AU - Diarra, Amidou
AU - Nebie, Issa
AU - Tiono, Alfred
AU - Soulama, Issiaka
AU - Ouedraogo, Alphonse
AU - Konate, Amadou
AU - Theisen, Michael
AU - Dodoo, Daniel
AU - Traore, Alfred
AU - Sirima, Sodiomon B
PY - 2012
Y1 - 2012
N2 - Background: Patient immune status is thought to affect the efficacy of anti-malarial chemotherapy. This is a subject of some importance, since evidence of immunity-related interactions may influence our use of chemotherapy in populations with drug resistance, as well as assessment of the value of suboptimal vaccines. The study aim was to investigate relationship between antibodies and anti-malarial drug treatment outcomes. Methods. Some 248 children aged 0.5 and 15 years were recruited prior to the high malaria transmission season. Venous blood (5 ml) was obtained from each child to measure antibody levels to selected malaria antigens, using ELISA. Blood smears were also performed to assess drug efficacy and malaria infection prevalence. Children were actively followed up to record clinical malaria cases. Results: IgG levels to MSP3 were always higher in the successfully treated group than in the group with treatment failure. The same observation was made for GLURP but the reverse observation was noticed for MSP1-19. Cytophilic and non-cytophilic antibodies were significantly associated with protection against all three antigens, except for IgG4 to MSP1-19 and GLURP. Conclusion: Acquired anti-malarial antibodies may play an important role in the efficacy of anti-malarial drugs in younger children more susceptible to the disease.
AB - Background: Patient immune status is thought to affect the efficacy of anti-malarial chemotherapy. This is a subject of some importance, since evidence of immunity-related interactions may influence our use of chemotherapy in populations with drug resistance, as well as assessment of the value of suboptimal vaccines. The study aim was to investigate relationship between antibodies and anti-malarial drug treatment outcomes. Methods. Some 248 children aged 0.5 and 15 years were recruited prior to the high malaria transmission season. Venous blood (5 ml) was obtained from each child to measure antibody levels to selected malaria antigens, using ELISA. Blood smears were also performed to assess drug efficacy and malaria infection prevalence. Children were actively followed up to record clinical malaria cases. Results: IgG levels to MSP3 were always higher in the successfully treated group than in the group with treatment failure. The same observation was made for GLURP but the reverse observation was noticed for MSP1-19. Cytophilic and non-cytophilic antibodies were significantly associated with protection against all three antigens, except for IgG4 to MSP1-19 and GLURP. Conclusion: Acquired anti-malarial antibodies may play an important role in the efficacy of anti-malarial drugs in younger children more susceptible to the disease.
U2 - 10.1186/1475-2875-11-79
DO - 10.1186/1475-2875-11-79
M3 - Journal article
C2 - 22439695
SN - 1475-2875
VL - 11
SP - 79
JO - Malaria Journal
JF - Malaria Journal
IS - 1
ER -
