Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria

P H Jakobsen; S D Morris-Jones; L Hviid; T G Theander; M Høier-Madsen; R A Bayoumi; B M Greenwood

Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria

P H Jakobsen, S D Morris-Jones, L Hviid, T G Theander, M Høier-Madsen, R A Bayoumi, B M Greenwood

37 Citations (Scopus)

Abstract

Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.

Original language	English
Journal	Immunology
Volume	79
Issue number	4
Pages (from-to)	653-7
Number of pages	4
ISSN	0019-2805
Publication status	Published - 1993

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@article{40867d80a07011dd86a6000ea68e967b,

title = "Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria",

abstract = "Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.",

author = "Jakobsen, {P H} and Morris-Jones, {S D} and L Hviid and Theander, {T G} and M H{\o}ier-Madsen and Bayoumi, {R A} and Greenwood, {B M}",

note = "Keywords: Adult; Antibodies, Antiphospholipid; Antibodies, Protozoan; Cardiolipins; Child; Enzyme-Linked Immunosorbent Assay; Gambia; Humans; Immunoglobulin G; Immunoglobulin M; Malaria, Falciparum; Phosphatidylcholines; Phosphatidylinositols; Sudan",

year = "1993",

language = "English",

volume = "79",

pages = "653--7",

journal = "Immunology. Supplement",

issn = "0953-4954",

publisher = "Wiley-Blackwell",

number = "4",

}

TY - JOUR

T1 - Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria

AU - Jakobsen, P H

AU - Morris-Jones, S D

AU - Hviid, L

AU - Theander, T G

AU - Høier-Madsen, M

AU - Bayoumi, R A

AU - Greenwood, B M

N1 - Keywords: Adult; Antibodies, Antiphospholipid; Antibodies, Protozoan; Cardiolipins; Child; Enzyme-Linked Immunosorbent Assay; Gambia; Humans; Immunoglobulin G; Immunoglobulin M; Malaria, Falciparum; Phosphatidylcholines; Phosphatidylinositols; Sudan

PY - 1993

Y1 - 1993

N2 - Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.

AB - Plasma levels of antibodies against phosphatidylinositol (PI), phosphatidylcholine (PC) and cardiolipin (CL) were measured by enzyme-linked immunosorbent assay (ELISA) in patients from malaria endemic area of Sudan and The Gambia. Some Sudanese adults produced IgM antibodies against all three types of phospholipids (PL) during an acute Plasmodium falciparum infection. The anti-PL antibody titre returned to preinfection levels in most of the donors 30 days after the disease episode. IgG titres against PI, PC and CL were low. In Gambian children with malaria, IgM antibody titres against PI and PC were significantly higher in those with severe malaria than in those with mild malaria. These results show that a proportion of malaria patients produce anti-PL antibodies during infection and that titres of these antibodies are associated with the severity of disease.

M3 - Journal article

C2 - 8406592

SN - 0953-4954

VL - 79

SP - 653

EP - 657

JO - Immunology. Supplement

JF - Immunology. Supplement

IS - 4

ER -

Anti-phospholipid antibodies in patients with Plasmodium falciparum malaria

Abstract

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